Fucan Sulfates and Their Anticoagulant Activities

Nagumo, Terukazu; Nishino, Takashi

doi:10.1201/9780203742815-18

Cited by 7 publications

(7 citation statements)

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“…from Pulau Langkawi, Malaysia is within the range. Studies also reported that the fucose composition also varies among species of seaweeds as well as its technique of fucoidan extraction [12]. As Ponce et al reported, fucoidan been extracted at room temperature and at 70°C possessed completely different chemical compositions [8].…”

Section: Fucose Content Of Fucoidan Extractmentioning

confidence: 99%

“…Besides, these particular factors also exhibit different biological activities of fucoidan. Biological activities of fucoidan mainly occur due to its degree of sulphation, structural peculiarities and molecular weight [12]. Fucoidan has a variety of biological functions such as antibacterial, antiviral, antioxidant, anti-cancer, anti-tumour as developed in nutraceutical products and dietary supplements [13].…”

Section: Introductionmentioning

confidence: 99%

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EFFECT OF EXTRACTION METHODS ON THE YIELD, FUCOSE CONTENT AND PURITY OF FUCOIDAN FROM Sargassum sp. OBTAINED FROM PULAU LANGKAWI, MALAYSIA

Baba

Mustapha²

2018

MJAS

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The objective of this study was to determine the effect of extraction methods on the yield, fucose content and purity of fucoidan that had been isolated from brown seaweed, Sargassum sp. The extraction of fucoidan was carried out based on the factorial design assigned, which involved three different parameters including two types of extraction (acid and alkaline), three different extraction temperatures (45, 65 and 85 °C) and three different extraction time (1, 3 and 5 hours). Results obtained showed that the best extraction parameter that gave the highest yield of fucoidan extract was the alkaline extraction at 65 °C for 3 hours. Alkaline extraction also produced higher purity and better quality of fucoidan compared to the fucoidan extracted by hydrochloric acidic.

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Section: Fucose Content Of Fucoidan Extractmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

EFFECT OF EXTRACTION METHODS ON THE YIELD, FUCOSE CONTENT AND PURITY OF FUCOIDAN FROM Sargassum sp. OBTAINED FROM PULAU LANGKAWI, MALAYSIA

Baba

Mustapha²

2018

MJAS

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“…According to Li, Lu, Wei, and Zhao, (2008), the term fucoidan refers to polysaccharides that contain l-fucose and sulfate groups. Sulfated fucans and fucoidans exhibit amongst other anticoagulant, anti-inflammatory, antitumor and antiviral properties (Ale, Mikkelsen, & Meyer, 2011;Berteau & Mulloy, 2003;Croci et al, 2011;Cunha & Grenha, 2016;Jiang et al, 2010;Nagumo & Nishino, 1996;Pomin & Mourão, 2008;Wijesinghe & Jeon, 2012). Lorbeer et al (2017) have recently conducted the sequential extraction of four brown seaweeds from southern Australia, among them M. pyrifera.…”

Section: Introductionmentioning

confidence: 99%

Chemical structure and biological properties of sulfated fucan from the sequential extraction of subAntarctic Lessonia sp (Phaeophyceae)

Leal

Mansilla

Matsuhiro

et al. 2018

Carbohydrate Polymers

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This work is related to the structural characterization of the sulfated polysaccharide from Lessonia sp and the study of its antioxidant and antiparasitic properties. Sequential extraction afforded D-mannitol as the only low MW sugar alcohol. Extraction with 2% CaCl 2 afforded in 3.0% yield, a sulfated fucan (SF). Its major fraction (48.5% yield), isolated by ion-exchange chromatography corresponds to a linear polymer of α-l-fucopyranosil residues linked 1→3, sulfated at the O-4 and partially at O-2 positions. By alkaline extraction, sodium alginate (10.3% yield) was obtained. The antioxidant capacity of SF by ESR showed high elimination index (IC 50 , mg/mL) of hydroxyl (0.27), alkoxy (10.05), and peroxyl (82.88) radicals in relation to commercial mannitol. SF showed activity against the epimastigote form of Trypanosoma cruzi parasite (250 µg/mL) and low cytotoxicity in murine cells (367 µg/mL). The elimination capacity of radicals in aqueous medium of SF would allow its potential biomedical application.

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“…Due to this complex of useful elements, brown algae can be used for prevention and treatment of endocrine diseases [11,12,13], cancer [15,16], caries [17], as well as for excretion of heavy metals and radionuclides [18]. The anticoagulation, contraceptive, and other activities typical for fucoidans are also studied [19].…”

Section: Introductionmentioning

confidence: 99%

Results of Cultivation of Japanese Kelp (<i>Saccharina japonica</i>) in Primorsky Krai, Russia

Gabaev¹

2016

IJNFS

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Animals and plants, living near human settlements in the three climatic zones, accumulate substances that allow them to resist extreme environmental factors. By consuming these plants and animals, people strengthen the immune system that also facilitates their existence in harsh conditions. Many of the world known species appreciated for their medicinal properties inhabit Primorsky Krai, which is located in three climatic zones. On land, these are plants of the family of Araliaceae, including the well-known ginseng; in the sea, the Japanese sea cucumber and brown algae, including the Japanese kelp Saccharina (=Laminaria) japonica. This publication provides the results of cultivation of commercially valuable Japanese kelp by several technologies at sea-based farms in Russia.

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Fucan Sulfates and Their Anticoagulant Activities

Cited by 7 publications

References 1 publication

EFFECT OF EXTRACTION METHODS ON THE YIELD, FUCOSE CONTENT AND PURITY OF FUCOIDAN FROM Sargassum sp. OBTAINED FROM PULAU LANGKAWI, MALAYSIA

EFFECT OF EXTRACTION METHODS ON THE YIELD, FUCOSE CONTENT AND PURITY OF FUCOIDAN FROM Sargassum sp. OBTAINED FROM PULAU LANGKAWI, MALAYSIA

Chemical structure and biological properties of sulfated fucan from the sequential extraction of subAntarctic Lessonia sp (Phaeophyceae)

Results of Cultivation of Japanese Kelp (<i>Saccharina japonica</i>) in Primorsky Krai, Russia

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Fucan Sulfates and Their Anticoagulant Activities

Cited by 7 publications

References 1 publication

EFFECT OF EXTRACTION METHODS ON THE YIELD, FUCOSE CONTENT AND PURITY OF FUCOIDAN FROM Sargassum sp. OBTAINED FROM PULAU LANGKAWI, MALAYSIA

EFFECT OF EXTRACTION METHODS ON THE YIELD, FUCOSE CONTENT AND PURITY OF FUCOIDAN FROM Sargassum sp. OBTAINED FROM PULAU LANGKAWI, MALAYSIA

Chemical structure and biological properties of sulfated fucan from the sequential extraction of subAntarctic Lessonia sp (Phaeophyceae)

Results of Cultivation of Japanese Kelp (&lt;i&gt;Saccharina japonica&lt;/i&gt;) in Primorsky Krai, Russia

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Results of Cultivation of Japanese Kelp (<i>Saccharina japonica</i>) in Primorsky Krai, Russia