Abstract:FTY720 is an FDA-approved sphingosine derivative drug for the treatment of multiple sclerosis. This compound blocks lymphocyte egress from lymphoid organs and autoimmunity through sphingosine 1-phosphate (S1P) receptor blockage. Drug repurposing of FTY720 has revealed improvements in glucose metabolism and metabolic diseases. Studies also demonstrate that preconditioning with this compound preserves the ATP levels during cardiac ischemia in rats. The molecular mechanisms by which FTY720 promotes metabolism are… Show more
“…Using a human cardiomyocyte cell line, the authors demonstrate that FTY720 activates STAT3 which in turn stimulates mitochondrial activation. STAT3 inhibitor treatment reverses this effect, indicating specificity in the beneficial consequences of FTY720 activation on cardiomyocyte mitochondrial function through STAT3 activation [11]. Ariana P. Vargas-Delgado and co-authors discuss in their review for this Special Issue the metabolic impact of Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) on the cardiovascular system.…”
“…Using a human cardiomyocyte cell line, the authors demonstrate that FTY720 activates STAT3 which in turn stimulates mitochondrial activation. STAT3 inhibitor treatment reverses this effect, indicating specificity in the beneficial consequences of FTY720 activation on cardiomyocyte mitochondrial function through STAT3 activation [11]. Ariana P. Vargas-Delgado and co-authors discuss in their review for this Special Issue the metabolic impact of Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) on the cardiovascular system.…”
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