FtsH Protease in the Thylakoid Membrane: Physiological Functions and the Regulation of Protease Activity

Kato, Yusuke; Sakamoto, Wataru

doi:10.3389/fpls.2018.00855

Cited by 125 publications

(114 citation statements)

References 80 publications

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“…One exception, however, is FtsH5, which accumulates to significantly higher levels in both sp1 ppi2 and rpn8a ppi2 double mutants. FtsH5 localizes to the thylakoid membrane 28 and its increased abundance is therefore expected to result in increased thylakoid membrane protein turnover. Thus, its elevated abundance is unrelated to the phenotype observed here.…”

Section: Discussionmentioning

confidence: 99%

Mild proteasomal stress improves photosynthetic performance in Arabidopsis chloroplasts

et al. 2020

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The proteasome is an essential protein-degradation machinery in eukaryotic cells that controls protein turnover and thereby the biogenesis and function of cell organelles. Chloroplasts import thousands of nuclear-encoded precursor proteins from the cytosol, suggesting that the bulk of plastid proteins is transiently exposed to the cytosolic proteasome complex. Therefore, there is a cytosolic equilibrium between chloroplast precursor protein import and proteasomal degradation. We show here that a shift in this equilibrium, induced by mild genetic proteasome impairment, results in elevated precursor protein abundance in the cytosol and significantly increased accumulation of functional photosynthetic complexes in protein import-deficient chloroplasts. Importantly, a proteasome lid mutant shows improved photosynthetic performance, even in the absence of an import defect, signifying that functional precursors are continuously degraded. Hence, turnover of plastid precursors in the cytosol represents a mechanism to constrain thylakoid membrane assembly and photosynthetic electron transport.

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Section: Discussionmentioning

confidence: 99%

Mild proteasomal stress improves photosynthetic performance in Arabidopsis chloroplasts

et al. 2020

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“…FtsH protease. It is an inner membrane-embedded zincdependent metalloprotease, involved in the egradation and assembly of protein complexes in the photosynthetic electrontransport pathways, and it acts on chloroplast manutention (Kato & Sakamoto, 2018).…”

Section: Identified Proteins From Chia Seedsmentioning

confidence: 99%

Chia Seed (Salvia hispanica L.) as a Source of Proteins and Bioactive Peptides with Health Benefits: A Review

Grancieri

Martino

Mejía

2019

Comp Rev Food Sci Food Safe

180

121

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The consumption of chia seed (Salvia hispanica L.) has increased in recent years due its high content of omega‐3 fatty acids and dietary fiber. This seed also has a high concentration of proteins and essential amino acids, becoming a promising source of bioactive peptides. The objective of this review was to identify the composition and the beneficial effects of chia seeds (S. hispanica L.), their proteins, peptides, and their potential impact on human health. The UniProt database was used to identify the chia proteins and their amino acid sequences. The BIOPEP database was used to analyze the peptides's bioactive potential. A total of 20 proteins were cataloged in chia seed, 12 of those were involved in the regular metabolic processes of the plant cells. However, eight proteins were specifically related to production and storage of plant lipids, thus explaining the high concentration of lipids in chia seeds (around 30%), especially omega‐3 fatty acids (around 20%). The analyses of amino acid sequences showed peptides with bioactive potential, including dipeptidyl peptidase‐IV inhibitors, angiotensin‐converting enzyme inhibitors, and antioxidant capacity. These results correlated with the main health benefits of whole chia seed in humans such as antioxidant capacity, and hypotensive, hypoglycemic, and anticholesterolemic effects. Such relation can be associated with chia protein and peptide compositions and therefore needs further investigation in vitro and in vivo.

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“…Dogra et al, (2019b) also confirmed that these Trp residues in D1 undergo oxidation, resulting in the generation of oxidized Trp variants, including NFK. Nonetheless, photodamage in PSII RC proteins facilitates a process called PSII repair, which involves a series of steps: 1) migration of damaged PSII RC from the grana core to the grana margin; 2) degradation via the FtsH protease; 3) reassembly via protein de novo synthesis; and 4) re-migration from the grana margin to the grana core (Kato and Sakamoto, 2018). The hetero-hexameric FtsH protease comprises four subunits, FtsH1, 2, 5, and 8.…”

Section: Damaged/unfolded/misfolded Protein Responses Via Rsmentioning

confidence: 99%

ROS-Driven Oxidative Modification: Its Impact on Chloroplasts-Nucleus Communication

Kim

2020

Front. Plant Sci.

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As a light-harvesting organelle, the chloroplast inevitably produces a substantial amount of reactive oxygen species (ROS) primarily through the photosystems. These ROS, such as superoxide anion, hydrogen peroxide, hydroxyl radical, and singlet oxygen, are potent oxidizing agents, thereby damaging the photosynthetic apparatus. On the other hand, it became increasingly clear that ROS act as beneficial tools under photo-oxidative stress conditions by stimulating chloroplast-nucleus communication, a process called retrograde signaling (RS). These ROS-mediated RS cascades appear to participate in a broad spectrum of plant physiology, such as acclimation, resistance, programmed cell death (PCD), and growth. Recent reports imply that ROS-driven oxidation of RSassociated components is essential in sensing and responding to an increase in ROS contents. ROS appear to activate RS pathways via reversible or irreversible oxidation of sensor molecules. This review provides an overview of the emerging perspective on the topic of "oxidative modification-associated retrograde signaling."

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FtsH Protease in the Thylakoid Membrane: Physiological Functions and the Regulation of Protease Activity

Cited by 125 publications

References 80 publications

Mild proteasomal stress improves photosynthetic performance in Arabidopsis chloroplasts

Mild proteasomal stress improves photosynthetic performance in Arabidopsis chloroplasts

Chia Seed (Salvia hispanica L.) as a Source of Proteins and Bioactive Peptides with Health Benefits: A Review

ROS-Driven Oxidative Modification: Its Impact on Chloroplasts-Nucleus Communication

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