FTO genotype is associated with body mass index and waist circumference in Mexican young adults

Abstract

Individual variations in the fat mass and obesityassociated (FTO) gene have been associated with obesity and BMI in diverse populations, but there are no reports in young Mexicans. We explored the association of a common FTO single-nucleotide polymorphism (SNP, rs805704) with obesity-related phenotypes in Mexican young adults. The FTO-SNP was genotyped using the fluorescent polarization method in college-age, apparently healthy subjects from the "UP AMIGOS" cohort (n = 251, 18 -25 yrs). Homozygotes for the A allele (15%, n = 38) were heavier (1.6 kg/m 2 and 6.2 kg) and had a larger waist circumference (WC, 4.8 cm) than G allele carriers. The FTO genotype was associated with BMI, weight and WC independently of age and sex and explained 2.7 to 3.1% of the variance in obesity-related phenotypes. The FTO genotype was also associated with fasting glucose (P = 0.0283). No other associations were found in the additive model. Despite our small sample size, we found that the FTO-rs805704 genotype influences obesity-related phenotypes young Mexicans. Previously observed FTO associations with fasting glucose were replicated. Previously reported associations with other metabolic traits likely represent the long-term consequences of obesity.

Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study

“…These results are consistent with those of previous studies suggesting the involvement of this gene in lipid metabolism [51, 52], obesity, T2DM [51–54], and MS in different populations [55–57]. Our sample size ( n  = 838) had power values of 72%, 74%, and 60% to detect associations between obesity status and rs3751812 (OR = 1.51), rs8050136 (OR = 1.52), and rs9939609 (OR = 1.44), respectively.…”

Genetic variation of FTO: rs1421085 T>C, rs8057044 G>A, rs9939609 T>A, and copy number (CNV) in Mexican Mayan school‐aged children with obesity/overweight and with normal weight

“…SNP rs8057044 was associated with BMI, weight, and WC independent of age and sex in young adults from San Luis Potosí, México. AA homozygosity was associated with a higher mean BMI than AG/GG, but without reaching the BMI values of overweight or obesity (BMI > 25; Terán‐Garcia et al, ). Our study found an association of rs8057044 with overweight (up to BMI 95th percentile) only in boys, supporting the effect of this FTO SNP in making boys heavier, but not obese.…”

“…Particularly for Mexican admixed populations , the FTO rs8057044 SNP influences obesity‐related phenotypes in young Mexicans (Terán‐Garcia et al, ). FTO SNPs rs9939609, rs1421085 , and rs17817449 were associated with class III obesity in adults (Villalobos‐Comparán et al, ).…”