2014
DOI: 10.1038/mp.2014.49
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FTO genotype and aging: pleiotropic longitudinal effects on adiposity, brain function, impulsivity and diet

Abstract: While overweight and obesity are associated with poor health outcomes in the elderly, the biological bases of obesity-related behaviors during aging are poorly understood. Common variants in the FTO gene are associated with adiposity in children and younger adults as well as with adverse mental health in older individuals. However, it is unclear whether FTO influences longitudinal trajectories of adiposity and other intermediate phenotypes relevant to mental health during aging. We examined whether a commonly … Show more

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Cited by 59 publications
(34 citation statements)
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“…In this line of evidence, we found that FTO variants associated with reduced longitudinal functioning in the medial prefrontal cortex and this reduction correlated with higher rates of impulsivity, behavioral disinhibition, and risky decision-making, which are common symptoms in BD (Chuang et al, 2015). These FTO-associated changes in brain-behavior relationship lead us to hypothesize that the link between BD symptomatology and eating behavior (particularly the way in which eating is controlled) could be a process modulated by FTO genetic variants.…”
Section: Discussionsupporting
confidence: 53%
See 1 more Smart Citation
“…In this line of evidence, we found that FTO variants associated with reduced longitudinal functioning in the medial prefrontal cortex and this reduction correlated with higher rates of impulsivity, behavioral disinhibition, and risky decision-making, which are common symptoms in BD (Chuang et al, 2015). These FTO-associated changes in brain-behavior relationship lead us to hypothesize that the link between BD symptomatology and eating behavior (particularly the way in which eating is controlled) could be a process modulated by FTO genetic variants.…”
Section: Discussionsupporting
confidence: 53%
“…In this line of evidence, we found that FTO variants associated with BMI only remained in BD patients, even when the BDC group had higher rates of obesity, which suggests that the effect of these variants modulating BMI could be higher in BD patients than in non‐BD obese individuals. Supporting this result, a neuro‐image study recently reported that carriers of FTO ‐obesity risk variants have a reduced longitudinal functioning in the medial prefrontal cortex and this reduction correlated with higher rates of impulsivity, behavioral disinhibition, and risky decision‐making, which are common symptoms in BD (Chuang et al., ). These FTO ‐associated changes in brain‐behavior relationship lead us to hypothesize that the link between BD symptomatology and eating behavior (particularly the way in which eating is controlled) could be a process modulated by FTO genetic variants.…”
Section: Discussionmentioning
confidence: 79%
“…Firstly, many genes are known to be pleiotropic, i.e. a single gene can affect many traits [18]. Transcription factors are a good example of this [19] but there are many other examples [20].…”
Section: Resultsmentioning
confidence: 99%
“…Overlap between genetic risk for obesity and white matter microstructural integrity (in the corpus callosum and superior fronto-occipital tract) has also been reported (Spieker et al, 2015). SNPs in a number of candidate genes, including FTO (Chuang et al, 2015), and NEGR1 (Dennis et al, 2014) have also been shown to contribute to both obesity and neural structure and/or function.…”
mentioning
confidence: 99%