FTO gene is related to obesity in Chilean Amerindian children and impairs HOMA-IR in prepubertal girls

Riffo, Benilde; Asenjo, Sylvia; Sáez, Katia; Aguayo, Claudio; Muñoz, Isabel; Bustos, Pablo; Celis-Morales, Carlos; Lagos, Jenny; Sapunar, J; Ulloa, Natalia

doi:10.1111/j.1399-5448.2011.00834.x

Cited by 23 publications

(33 citation statements)

References 42 publications

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“…Africa is an especially important continent to study because of its complex population history, which results in high levels of genetic and phenotypic variation. The FTO obesity association is well established in populations of Caucasian ancestry (14,98–112) as well as in Asians (19,113–135), and consistent findings have also been documented in other ethnicities such as populations from Australia (136) and South America (137–139). However, studies conducted so far in African populations (Table 1) have frequently reported negative findings.…”

Section: What Have Studies In Divergent Ethnic Population Told Us?mentioning

confidence: 57%

“…The FTO obesity association is well established in populations of Caucasian ancestry (14,(98)(99)(100)(101)(102)(103)(104)(105)(106)(107)(108)(109)(110)(111)(112) as well as in Asians (19,, and consistent findings have also been documented in other ethnicities such as populations from Australia (136) and South America (137)(138)(139). However, studies conducted so far in African populations ( (147) and presented strong evidence for an association between BMI and rs3751812.…”

Section: Obesity Reviewsmentioning

confidence: 72%

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The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO

2012

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In 2007, the first common genetic variants were identified, which undoubtedly affect our susceptibility to obesity. These variants are located in the fat mass and obesity-associated gene FTO. Since then, over 50 loci for common obesity have been identified. As the research on these loci is still at an early stage, there is a great need to review, for clarification purposes, the current research on FTO, as this is likely to influence future studies. Based on the current knowledge, FTO seems to be directly involved in the regulation of energy intake, but there is an urgent need for the identification of regulatory polymorphisms. Thus, herein, we discuss current knowledge and highlight putative functional regions in FTO based on published data and computer-based analysis.

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Section: What Have Studies In Divergent Ethnic Population Told Us?mentioning

confidence: 57%

Section: Obesity Reviewsmentioning

confidence: 72%

The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO

2012

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“…In the first genetic studies on children with obesity, the relationship between the FTO rs9939609 polymorphism and body weight was indicated in girls but not in boys . Moreover, the FTO rs9939609 polymorphism is associated with higher homeostasis model assessment index in girls before puberty, but not in boys , although further studies, including ours, did not confirm these sex‐associated effects.…”

Section: Relationships Between Genetic Polymorphisms and Cardiovasculmentioning

confidence: 81%

The influence of clinical and genetic factors on the development of obesity in children with type 1 diabetes

Łuczyński

Głowińska-Olszewska

Bossowski

2016

Diabetes Metabolism Res

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The exact cause of the obesity epidemic remains unknown; however, both environmental and genetic factors are involved. People at risk of developing obesity include children with type 1 diabetes mellitus (T1DM), which in turn increases their cardiovascular disease risk. Here, we discuss the clinical and genetic factors influencing weight in patients with T1DM. In children with T1DM, the presence of obesity depends mainly on sex, metabolic control, and disease duration. However, genetic factors, including the fat mass and obesity-associated (FTO) gene, are also associated with body weight. Indeed, children with the FTO gene rs9939609 obesity-risk allele (homozygous = AA or heterozygous = AT) are predisposed to a higher body mass index and have a greater risk of being overweight or obese. However, in this review, we show that FTO gene polymorphisms only have a small effect on body weight in children, much weaker than the effect of clinical factors. The association between FTO gene polymorphisms and body weight is only statistically significant in children without severe obesity. Moreover, other genetic factors had no effect on weight in patients with T1DM, and further research involving larger populations is required to confirm the genetic basis of diabetes and obesity. Therefore, identifying the clinical features of children with T1DM, such as their initial body mass index, sex, metabolic control, and disease duration, will still have the strongest effect on reducing risk factors for cardiovascular diseases. Physicians should pay close attention to modifiable elements of these relationships, for example, metabolic control and energy and insulin intake, when caring for patients with T1DM. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Further adjustment for BMI and age did not alter the result, but the level of significance was reduced. [68] In contrast, the association was not observed among normal weight girls or the normal weight or obese boys.…”

Section: The Effect Of Fat Mass and Obesity-associated On Glucose Hommentioning

confidence: 95%

The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults

Shinozaki

Okuda

2012

Indian J Endocr Metab

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Genome-wide association analyses have revealed common gene variations related to obesity. Variants of the fat mass and obesity-associated (FTO) gene among more than 40 genes studied were most closely associated with obesity, but the association varies among ethnicities. Moreover, the effect is significant in people of European descent as well as Asians, but less significant among people of African descent. Although the variants were also associated with type 2 diabetes and glucose homeostasis, the associations were attenuated or abolished after adjusting for adiposity. The present review considers our current understanding of the effects of the FTO variants in different ethnic groups and in adults and children.

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FTO gene is related to obesity in Chilean Amerindian children and impairs HOMA-IR in prepubertal girls

Abstract: In summary, we confirm the association of the FTO gene single-nucleotide polymorphism rs9939609 with obesity in Chilean Amerindian children. Furthermore we show an association between the risk allele (A) and insulin resistance-related markers in prepubertal obese girls.

Cited by 23 publications

References 42 publications

The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO

The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO

The influence of clinical and genetic factors on the development of obesity in children with type 1 diabetes

The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults

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