FTIR study of protective action of deferoxamine and deferiprone on the kidney tissues of aluminum loaded mice

Sivakumar, S.; Khatiwada, Chandra Prasad; Sivasubramanian, J.; Raja, Boobalan

doi:10.1016/j.saa.2013.09.011

Cited by 8 publications

(8 citation statements)

References 39 publications

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“…It is partially considered as a significant marker of renal function. The Plasma Uac (Uric acid) elevation recorded in this study after AlCl 3 exposure is in agreement with the majority of researches (Sivakumar et al, 2014;Al-Qhtani and Farran, 2017), and is also supported by the findings of Rudenko et al (1998) who reported that AlCl 3 intensifies the acid-secretion function of the kidney and changes the transport of sodium.…”

Section: Discussionsupporting

confidence: 92%

The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum

Mokrane¹,

Kharoubi²,

Tahari³

et al. 2020

J. Med. Plants Res.

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The main sources of human exposure to aluminum are found in the extensive presence of the metal in the environment and its growing industrial applications. The present study was carried out to determine the effectiveness of the Thymus vulgaris L. extract in alleviating aluminum chloride (AlCl 3 ) toxicity on biochemical and antioxidant parameters. The experiment's rats were divided into five groups: a control group; an intoxicated group (300 mg AlCl 3 /kg bw); and three other groups which were given AlCl 3 (300mg/kg/bw) then T. vulgaris. L extract (T.v), Malic Acid (MA) and Vitamin E (Vit E) at a concentration of 150mg/kg/bw. Each group was given its respective dosage, daily for 90 days. The results showed a significant decrease in the body/liver/kidney weights, the plasma total protein (T. Protein) and albumin (Alb) levels (p≤0.05) in the intoxicated rats group. However, a significant increase in the plasma uric acid (Uac), alkaline (AlP) and acid phosphatase (AcP) levels was noted (p≤0.05) in the same group. The amount of aluminum, TBARS and nitrate/nitrite (NO) in the liver and kidney tissues of the rats treated with AlCl 3 was also found to have increased (p≤0.05), while the levels of glutathione peroxidase (GSH-Px) and glutathione transferase (GSH-St) have decreased significantly (p≤0.05). These altered parameters were restored in the rats treated with the T. vulgaris L. extract. Therefore, due to these beneficial effects, T. vulgaris L. could potentially be used to antagonize AlCl 3 toxicity.

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Section: Discussionsupporting

confidence: 92%

The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum

Mokrane¹,

Kharoubi²,

Tahari³

et al. 2020

J. Med. Plants Res.

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“…RS is used to investigate the disease development and to test the efficacy of potential medications. Hepatic tissue [33][34][35][36][37][38][39] and cells [19,38] were studied by RS to research for cancer and hepatitis in different animal models.…”

Section: Introductionmentioning

confidence: 99%

Raman spectroscopy analysis of lipid droplets content, distribution and saturation level in Non‐Alcoholic Fatty Liver Disease in mice

Kochan

Maślak

Krafft

et al. 2014

Journal of Biophotonics

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Non-Alcoholic Fatty Liver Disease (NAFLD) is a common liver disorder, characterized by an excessive lipids deposition within the hepatic tissue. Due to the lack of clear-cut symptoms and optimal diagnostic method, the actual prevalence of NAFLD and its pathogenesis remains unclear, especially in the early stages of progression. In the presented work confocal Raman microspectroscopy was used to investigate alterations in the chemical composition of the NAFLD-affected liver. We have investigated two NAFLD models, representative for macrovesicular and microvesicular steatosis, induced by High Fat Diet (60 kcal %) and Low Carbohydrate High Protein Diet (LCHP), respectively. In both models we confirmed the development of NAFLD, manifested by the presence of lipid droplets (LDs), but of different sizes. Model of macrovesicular steatosis was characterized by large LDs, whereas in the microvesicular steatosis model small droplets were found. In both models, however, we observed a significant decrease in the degree of unsaturation of lipids, in comparison to the control. In addition, for both models, the impact of medical treatment with selected drugs (perindopril and nicotinic acid, respectively) was tested, indicating a significant influence of medicine not only on the occurrence and size of the droplets, but also on their composition. In both cases the drug treatment resulted in an increase of the degree of unsaturation of lipids forming droplets. Confocal Raman microspectroscopy was proven to be a powerful tool providing detailed insight into selected areas of hepatic tissue, following the NAFLD pathogenesis and diagnostic potential of the applied drugs.

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“…Deferiprone (DFP), a newer, orally administered iron chelator, was also demonstrated to attenuate AKI in two studies: a cisplatin-induced AKI model in rats, 33 and an aluminum chlorideinduced AKI model in mice. 37 In the latter study, combination therapy with DFP and DFO resulted in even greater renal protection compared with DFP alone. 37 Finally, administration of other iron-binding compounds, including apotransferrin and neutrophil gelatinase-associated lipocalin, has been shown to attenuate the severity of renal injury after IRI.…”

Section: Iron Chelating Agentsmentioning

confidence: 90%

Iron Chelation as a Potential Therapeutic Strategy for AKI Prevention

Sharma

Leaf

2019

JASN

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AKI remains a major public health concern. Despite years of investigation, no intervention has been demonstrated to reliably prevent AKI in humans. Thus, development of novel therapeutic targets is urgently needed. An important role of iron in the pathophysiology of AKI has been recognized for over three decades. When present in excess and in nonphysiologic labile forms, iron is toxic to the kidneys and multiple other organs, whereas iron chelation is protective across a broad spectrum of insults. In humans, small studies have investigated iron chelation as a novel therapeutic strategy for prevention of AKI and extrarenal acute organ injury, and have demonstrated encouraging initial results. In this review, we examine the existing data on iron chelation for AKI prevention in both animal models and human studies. We discuss practical considerations for future clinical trials of AKI prevention using iron chelators, including selection of the ideal clinical setting, patient population, iron chelating agent, and dosing regimen. Finally, we compare the key differences among the currently available iron chelators, including pharmacokinetics, routes of administration, and adverse effects.

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FTIR study of protective action of deferoxamine and deferiprone on the kidney tissues of aluminum loaded mice

Cited by 8 publications

References 39 publications

The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum

The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum

Raman spectroscopy analysis of lipid droplets content, distribution and saturation level in Non‐Alcoholic Fatty Liver Disease in mice

Iron Chelation as a Potential Therapeutic Strategy for AKI Prevention

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