FT-IR Spectroscopy Applied for Identification of a Mineral Drug Substance in Drug Products: Application to Bentonite

Abstract

The aim of this study is to prove the effectiveness of IR spectroscopy as an identification test able to discriminate between mineral compounds in mixtures. This work is concerned with the physical characterisation of purified bentonite, bentonite in organic mixtures and organic excipients, and mineralized organic mixture containing bentonite using FT-IR spectroscopy. The different spectra were compared with each other in order to determine fingerprints of bentonite represented by bands located at 3632 cm−1 and 3437 cm−1. The analysis of the spectra of the nonmineralized mixture demonstrates the presence of two bands at 1454 and 2928 cm−1, superimposed on those of the excipients and which disappear after 2 hours of mineralization at 500°C. Finally, we notice a displacement of the stretching band of H2O to the right with increasing the proportion of the excipients.

Eco-friendly approach for biosorption of Pb2+ and carcinogenic Congo red dye from binary solution onto sustainable Ulva lactuca biomass

“…Additionally, new two peaks have appeared in the FTIR spectrum of the Ulva lactuca biomass sample after the biosorption process of Congo red dye and Pb 2+ at 2974 and 2928 cm -1 . Vibrational band obtained at 2974 cm -1 is attributed to C-H group 76 , peak present at 2928 cm -1 is attributed to C-H stretching (-CH 3 and -CH 2 groups) which is specific to organic compounds such as glucose 77 . The vibrational FTIR peak located at 2354 cm -1 is corresponding to C-H stretching from aromatic group 78 is transformed into the vibrational peak at 2359 cm -1 which is assigned to the N-H or C=O stretching vibrations 79 .…”

Characterization of composite material from the copolymerized polyphenolic matrix with treated cassava peels starch

“…The spectra were collected with 1.50 mg–1.55 mg material using attenuated total reflectance. The sample spectra were related to literature reference spectra to identify functional groups [ 36 ]. The samples of the particleboards were scanned using the ATR with less emphasis on the sample preparation.…”

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“…The process consisted of dispersing the sample (crude drug, physical mixture of drug and excipients) in potassium bromide and it was compressed into discs by creating a pressure of 5 tons in a hydraulic press for 5 min. The pellet was kept in the path of light and the spectrum was recorded 6 .…”