FT-IR Method Development and Validation for Quantitative Estimation of Zidovudine in Bulk and Tablet Dosage Form

Bansal, Ranju; Guleria, A.; Acharya, Pratap Chandra

doi:10.1055/s-0032-1333297

Cited by 14 publications

(5 citation statements)

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“…Although NIR estimation is gaining popularity in pharmaceutical industry, but several drawbacks such as broadening of the absorption bands in the NIR spectra and its inability to distinguish closely related derivatives limits its usefulness [7]. The vibrational bands of MIR spectra provide better information regarding functional groups which offers broader scope to identify similar structures and presence of typical pharmaceutical excipients [8,9]. Doxorubicin hydrochloride (DOX) is a naturally occurring anthracycline derivative (Fig.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of doxorubicin hydrochloride and arterolane maleate by mid IR spectroscopy using transmission and reflectance modes

2021

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Background Environment-friendly fast and accurate mid-infrared spectroscopic methods have been developed for the quantitative analysis of doxorubicin hydrochloride (DOX) and arterolane maleate (ALM) in bulk and marketed formulations. Both transmittance and reflectance modes have been used for the analysis and a comparison has been drawn for better accuracy. The analytical methods were validated in accordance with International Council for Harmonisation (ICH) guidelines Results The proposed methods have been successfully developed and validated for the quantification of doxorubicin and arterolane maleate in solid bulk and dosage form. High recovery values in both the modes, while analysing DOX and ALM, indicated good accuracy of the methods. The methods showed excellent repeatability and intermediate precision [% RSD (Relative Standard Deviation < 2.0%]. The assay values of the drugs in solid dosage forms were also found close to the labelled claim. Conclusion The proposed Fourier transform infrared (FT-IR) spectroscopic methods were found to be specific, reproducible, valid and could be used as general methods for the quantification of most of the solid drug preparations such as tablets, capsules and powders.

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Section: Introductionmentioning

confidence: 99%

Quantitative analysis of doxorubicin hydrochloride and arterolane maleate by mid IR spectroscopy using transmission and reflectance modes

2021

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“…In the present decade, several UV spectrophotometric, HPLC and LC-MS/MS methods have been reported so far for the estimation of efavirenz alone and in combination with other drugs in pharmaceutical samples (Kadam et al, 2012;Bansal et al, 2013;Ahmed et al, 2013;Matkovic et al, 2005). The official methods for the determination of efavirenz as a bulk drug and in tablets are based on liquid chromatography (IP, 2011).…”

Section: Introductionmentioning

confidence: 99%

FTIR spectroscopy for estimation of efavirenz in raw material and tablet dosage form

et al. 2015

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A Fourier transform infrared (FTIR) spectrophotometric method was developed for rapid and direct measurement of efavirenz in pharmaceutical formulations. The method involves extraction of efavirenz from tablets with chloroform by sonication and the direct measurement of the absorbance in liquid phase using a reduced path length cell. In general, the spectrum was measured in transmission mode. The equipment was configured to collect a spectrum at 8 cm-1 resolution and 45 scans per sec .The spectra were collected between 4000 cm-1 and 450cm-1, the band obtained at 1750cm-1 (carbonyl group) showed intense, clear peak in the liquid phase for quantitation. The method was validated as per ICH guidelines. The method fulfilled most validation requirements in the linearity range 200-1000µg/mL. The coefficient of determination, limit of detection and quantification was found to be 0.993, 49.12?g/mL and 148.84?g/mL respectively. Results of developed FTIR method were compared with the results obtained with the existing UV method statistically by using t-test, which indicated that there is no significant difference between the methods at P=0.05. The proposed FTIR method reduces the solvent consumption and also eliminates the use of reagents. Thus the developed method offers a good alternative for the quantitative estimation of efavirenz in bulk and pharmaceutical dosage forms and also to quantify efavirenz when combined with other API in the same dosage form.International Current Pharmaceutical Journal, May 2015, 4(6): 390-395

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“…Table 7 shows the different trials, which were undertaken for formulating FDTs. [22][23] For the preparation of Fast Dissolving Tablets of Rosuvastatin Calcium, various excipients were screen for the best formulation and their concentrations were optimized thereafter. In earlier studies it was suggested that the sodium starch glycolate has positive impact on the disintegration time of solid dispersion of various poorly soluble drugs increasing their dissolution rate.…”

Section: Fast Dissolving Tablets Of Rosuvastatin Calciummentioning

confidence: 99%

Solubility enhancement of poorly aqueous soluble novel drug using natural gum as carriers

Katual¹,

Singh²,

Harikumar³

2020

PJMS

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The current article is based on the concept to enhance the solubility and dissolution rate of a model drug, Rosuvastatin Calcium, which is BCS class-II drug with anti-hyperlipidemic potential. The reported bioavailability from oral route of drug is only 20%. So aim of current study is to improve the solubility and dissolution rate of a poorly water-soluble drug Rosuvastatin Calcium, by solid dispersion technique. Physical mixtures and solid dispersions were prepared using natural polymers A. Marmelos in different to drug to carrier ratios. Prepared formulations were characterized in solid state by FTIR analysis, powder X-ray diffraction, Scanning electron microscopy and in-vitro dissolution study. Solid state characterizations indicated the Rosuvastatin Calcium was present in amorphous form and entrapped in polymer matrix. In contrast to the very slow dissolution rate of pure Rosuvastatin Calcium, the dispersion of the drug in the polymers considerably enhanced the dissolution rate. The mixtures of solid dispersion and excipients were evaluated for pre-compression parameters. After then fast dissolving tablets were prepared by direct compression technique. The formulated tablets were evaluated by post compression parameters. In-vitro drug release performance of the developed formulations was investigated.

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FT-IR Method Development and Validation for Quantitative Estimation of Zidovudine in Bulk and Tablet Dosage Form

Cited by 14 publications

References 1 publication

Quantitative analysis of doxorubicin hydrochloride and arterolane maleate by mid IR spectroscopy using transmission and reflectance modes

Quantitative analysis of doxorubicin hydrochloride and arterolane maleate by mid IR spectroscopy using transmission and reflectance modes

FTIR spectroscopy for estimation of efavirenz in raw material and tablet dosage form

Solubility enhancement of poorly aqueous soluble novel drug using natural gum as carriers

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