FT-IR, FT-Raman and UV-Visible Spectral Analysis on (E)-N′-(thiophen-2-ylmethylene) Nicotinohydrazide

Bharanidharan, S.; Saleem, H.; Subashch,; rabose, S; Suresh, M.; Babu, N. Ramesh

doi:10.21767/2572-4657.100007

Cited by 4 publications

(2 citation statements)

References 19 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All samples presented a band narrowing and a shift at around 948 cm −1 . This change is a confirmation of the incorporation of Ica in the samples, as this band is related to the Ica FTIR spectrum and is correlated to C-H out of plane bending vibrations [63][64][65]. These observed alterations could also be an indicator of interactions of Ica with the silanol groups of the bioactive glass spheres via hydrogen-bonding [24,[66][67][68].…”

Section: Loading Efficiency and Cumulative Release Of Icariinmentioning

confidence: 52%

In vitro effects of the co-release of icariin and strontium from bioactive glass submicron spheres on the reduced osteogenic potential of rat osteoporotic bone marrow mesenchymal stem cells

Mosqueira

Barrioni²,

Martins³

et al. 2020

Biomed. Mater.

View full text Add to dashboard Cite

Osteoporosis is a metabolic disease that affects bone tissue and is highly associated with bone fractures. Typical osteoporosis fracture treatments, such as bisphosphonates and hormone replacement, present important challenges because of their low bioavailability on the site of action. Options to overcome this issue are systems for the local release of therapeutic agents such as bioactive glasses containing therapeutic molecules and ions. These agents are released during the dissolution process, combining the drugs and ion therapeutic effects for osteoporosis treatment. Among the therapeutic agents that can be applied for bone repair are strontium (Sr) ion and phytopharmaceutical icariin, which have shown potential to promote healthy bone marrow stem cells osteogenic differentiation, increase bone formation and prevent bone loss. Submicron Sr-containing bioactive glass mesoporous spheres with sustained ion release capacity were obtained. Icariin was successfully incorporated into the particles, and the glass composition influenced the icariin incorporation efficiency and release rates. In this work, for the first time, Sr and icariin were incorporated into bioactive glass submicron mesoporous spheres and the in vitro effects of the therapeutic agents release were evaluated on the reduced osteogenic potential of rat osteoporotic bone marrow mesenchymal stem cells, and results showed an improvement on the reduced differentiation potential.

show abstract

Section: Loading Efficiency and Cumulative Release Of Icariinmentioning

confidence: 52%

In vitro effects of the co-release of icariin and strontium from bioactive glass submicron spheres on the reduced osteogenic potential of rat osteoporotic bone marrow mesenchymal stem cells

Mosqueira

Barrioni²,

Martins³

et al. 2020

Biomed. Mater.

View full text Add to dashboard Cite

show abstract

“…We consider this band to be due to N-N stretching vibration from the hydrazide residue. The identifications of this stretching vibration is a difficult task, but there is literary evidence to support our assumption (Bharanidharan et al 2017;Gulaczyk et al 2003).…”

Section: Chemistrymentioning

confidence: 66%

Synthesis and preliminary hepatotoxicity evaluation of new caffeine-8-(2-thio)-propanoic hydrazid-hydrazone derivatives

Mitkov¹,

Kondeva-Burdina²,

Zlatkov³

2019

PHAR

View full text Add to dashboard Cite

New series of caffeine-8-(2-thio)-propanoic hydrazid-hydrazone derivatives were designed and synthesized. The targed compounds were obtained in yields of 51 to 96% and their structures were elucidated by FTIR, 1H NMR, 13C NMR, MS and microanalyses. All of the compounds were found to be “drug-like” as they fulfill the criteria of drug-likeness, which includes the MDDR-like rule. The tested compounds were subjected to in silico prediction of substrate/metabolite specificity and Drug Induced Liver Injury (DILI). The prediction for indicated that the evaluated compounds would most probably act as CYP1A2 substrates. The performed in vitro studies didn’t reveal statistically significant hepatotoxicity of the tested compounds, probably due to the pro-oxidant effects expressed on sub-cellular (isolated rat liver microsomes) level. The obtained experimental results confirmed the predicted low hepatotoxicity for the tested structures. Based on these results the compounds may be considered as promising structures for design of future molecules with low hepatotoxicity.

show abstract

Direct synthesis of a chelating carboxamide derivative and its application for thorium extraction from Abu Rusheid ore sample, South Eastern Desert, Egypt

Atia

Gado

Cheira

et al. 2021

International Journal of Environmental Analytical Chemistry

View full text Add to dashboard Cite

FT-IR, FT-Raman and UV-Visible Spectral Analysis on (E)-N′-(thiophen-2-ylmethylene) Nicotinohydrazide

Cited by 4 publications

References 19 publications

In vitro effects of the co-release of icariin and strontium from bioactive glass submicron spheres on the reduced osteogenic potential of rat osteoporotic bone marrow mesenchymal stem cells

In vitro effects of the co-release of icariin and strontium from bioactive glass submicron spheres on the reduced osteogenic potential of rat osteoporotic bone marrow mesenchymal stem cells

Synthesis and preliminary hepatotoxicity evaluation of new caffeine-8-(2-thio)-propanoic hydrazid-hydrazone derivatives

Direct synthesis of a chelating carboxamide derivative and its application for thorium extraction from Abu Rusheid ore sample, South Eastern Desert, Egypt

Contact Info

Product

Resources

About