FSP1: a key regulator of ferroptosis

Li, Wentao; Liang, Liu Sen; Liu, Siyi; Yun, Hong Shik; Zhou, Yanhong

doi:10.1016/j.molmed.2023.05.013

Cited by 54 publications

(31 citation statements)

References 93 publications

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“…85 cycle. 86 The FSP1-CoQ10-NAD(P)H pathway operates as an independent parallel system that synergistically works with GPX4 and glutathione to inhibit LPO and ferroptosis. 46,87,88 For instance, curcumin treatment could effectively inhibit the expression of GPX4 and FSP1 in A549 CD133 + cells, leading to the induction of ferroptosis and the inhibition of their self- renewal potential.…”

Section: Ferroptosis Inducersmentioning

confidence: 99%

“…Studies have shown that the inactivation of GPX4 may be associated with the inhibition of DNA damage repair response through the suppression of nucleophosmin 1 (NPM1) phosphorylation . FSP1 functions via the FSP1-CoQ10-NAD(P)H axis and the vitamin K oxidation–reduction cycle . The FSP1-CoQ10-NAD(P)H pathway operates as an independent parallel system that synergistically works with GPX4 and glutathione to inhibit LPO and ferroptosis. ,, For instance, curcumin treatment could effectively inhibit the expression of GPX4 and FSP1 in A549 CD133 + cells, leading to the induction of ferroptosis and the inhibition of their self-renewal potential .…”

Section: Ferroptosis Inducers and Their Application In Cancer Therapymentioning

confidence: 99%

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Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Shi,

Chen,

2024

J. Med. Chem.

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Ferroptosis is a type of iron-dependent programmed cell death characterized by the dysregulation of iron metabolism and the accumulation of lipid peroxides. This nonapoptotic mode of cell death is implicated in various physiological and pathological processes. Recent findings have underscored its potential as an innovative strategy for cancer treatment, particularly against recalcitrant malignancies that are resistant to conventional therapies. This article focuses on ferroptosis-based therapeutic strategies for precision cancer treatment, covering the molecular mechanisms of ferroptosis, four major types of ferroptosis inducers and their inhibitory effects on diverse carcinomas, the detection of ferroptosis by fluorescent probes, and their implementation in image-guided therapy. These state-of-the-art tactics have manifested enhanced selectivity and efficacy against malignant carcinomas. Given that the administration of ferroptosis in cancer therapy is still at a burgeoning stage, some major challenges and future perspectives are discussed for the clinical translation of ferroptosis into precision cancer treatment. ■ SIGNIFICANCE • The potential of ferroptosis as an innovative strategy for precision cancer therapy is highlighted. • Recent advances are discussed from three perspectives: molecular mechanism and regulation, anti-cancer ferroptosis inducers, and ferroptosis probes for image-guided therapy. • The strengths and weaknesses of ferroptosis modulators and probes are analyzed in terms of current progress and technical barriers. • Future perspectives are emphasized to advance ferroptosis-based therapies toward clinical use for cancer treatment.

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Section: Ferroptosis Inducersmentioning

confidence: 99%

Section: Ferroptosis Inducers and Their Application In Cancer Therapymentioning

confidence: 99%

Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Shi,

Chen,

2024

J. Med. Chem.

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“…Ferroptosis suppressor protein 1 (FSP1), formerly known as AIFM2, is a flavoprotein that was identified to be closely associated with ferroptosis and independent of the GPX4-GSH pathway ( 54 ). FSP1 is modified by N-terminal myristoylation and targets a variety of cell membrane structures including cytoplasmic membranes, Golgi apparatus, and perinuclear structures, and mutating the myristoyl modification site of FSP1 loses its FSP1-mediated anti- ferroptosis function ( 55 ).…”

Section: Ferroptosis Defense Pathwaysmentioning

confidence: 99%

A deep insight into ferroptosis in lung disease: facts and perspectives

Zhang,

Xiang,

et al. 2024

Front. Oncol.

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In the last decade, ferroptosis has received much attention from the scientific research community. It differs from other modes of cell death at the morphological, biochemical, and genetic levels. Ferroptosis is mainly characterized by non-apoptotic iron-dependent cell death caused by iron-dependent lipid peroxide excess and is accompanied by abnormal iron metabolism and oxidative stress. In recent years, more and more studies have shown that ferroptosis is closely related to the occurrence and development of lung diseases. COPD, asthma, lung injury, lung fibrosis, lung cancer, lung infection and other respiratory diseases have become the third most common chronic diseases worldwide, bringing serious economic and psychological burden to people around the world. However, the exact mechanism by which ferroptosis is involved in the development and progression of lung diseases has not been fully revealed. In this manuscript, we describe the mechanism of ferroptosis, targeting of ferroptosis related signaling pathways and proteins, summarize the relationship between ferroptosis and respiratory diseases, and explore the intervention and targeted therapy of ferroptosis for respiratory diseases.

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“…NRF2 has a significant role in the upregulation of the expression of gene clusters engaged in the iron and ROS metabolism NAD(P)H quinone oxidoreductase 1 (NQO1), FTH1 through the p62-Keap1-NRF2 pathway and heme oxygenase 1 (HO1) [ 111 ].…”

Section: Ferroptosis Inducers and Inhibitors And Other Causes Of Ferr...mentioning

confidence: 99%

Deeper insight into ferroptosis: association with Alzheimer’s, Parkinson’s disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis

Yadav,

Choudhary,

Gacem

et al. 2023

Redox Report

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Ferroptosis is an emerging and novel type of iron-dependent programmed cell death which is mainly caused by the excessive deposition of free intracellular iron in the brain cells. This deposited free iron exerts a ferroptosis pathway, resulting in lipid peroxidation (LiPr). There are mainly three ferroptosis pathways viz. iron metabolism-mediated cysteine/glutamate, and LiPr-mediated. Iron is required by the brain as a redox metal for several physiological activities. Due to the iron homeostasis balance disruption, the brain gets adversely affected which further causes neurodegenerative diseases (NDDs) like Parkinson's and Alzheimer's disease, strokes, and brain tumors like glioblastoma (GBS), and glioma. Nanotechnology has played an important role in the prevention and treatment of these NDDs. A synergistic effect of nanomaterials and ferroptosis could prove to be an effective and efficient approach in the field of nanomedicine. In the current review, the authors have highlighted all the latest research in the field of ferroptosis, specifically emphasizing on the role of major molecular key players and various mechanisms involved in the ferroptosis pathway. Moreover, here the authors have also addressed the correlation of ferroptosis with the pathophysiology of NDDs and theragnostic effect of ferroptosis and nanomaterials for the prevention and treatment of NDDs.

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FSP1: a key regulator of ferroptosis

Cited by 54 publications

References 93 publications

Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

A deep insight into ferroptosis in lung disease: facts and perspectives

Deeper insight into ferroptosis: association with Alzheimer’s, Parkinson’s disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis

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