FSH preserves the viability of hypoxic granulosa cells via activating the HIF‐1α‐GAS6‐Axl‐Akt pathway
Chengyu Li,
Chen Fu,
Tong He
et al.
Abstract:The developmental fate of ovarian follicles is primarily determined by the survival status (proliferation or apoptosis) of granulosa cells (GCs). Owing to the avascular environment within follicles, GCs are believed to live in a hypoxic niche. Follicle‐stimulating hormone (FSH) has been reported to improve GCs survival by governing hypoxia‐inducible factor‐1α (HIF‐1α)‐dependent hypoxia response, but the underlying mechanisms remain poorly understood. Growth arrest‐specific gene 6 (GAS6) is a secreted ligand of… Show more
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