FSH/LH-Dependent Upregulation of Ahr in Murine Granulosa Cells Is Controlled by PKA Signaling and Involves Epigenetic Regulation

Matvere, Antti; Teino, Indrek; Varik, Inge; Kuuse, Sulev; Tiido, Tarmo; Kristjuhan, Arnold; Maimets, Toivo

doi:10.3390/ijms20123068

Cited by 17 publications

(13 citation statements)

References 78 publications

(120 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, FSH/LH > 3 was found in the heat exposure group, indicating ovarian hyporesponsiveness or ovarian insufficiency [30]. In women, the synergistic effect of LH and FSH on ovarian follicles and granulosa cells led to an increase of estradiol in the blood, which is essential for the production of estrogen and progesterone [31]. Thus, FSH/LH is one of the clinical indexes to evaluate the ovarian reserve function.…”

mentioning

confidence: 99%

Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress

An¹,

Chen²,

Li³

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

High-temperature exposure is detrimental to women’s reproductive health; however, the impact caused by long-term high temperature is not comprehensive, and a stable model of estrous cycle disorder induced by a high temperature is yet lacking. Herein, we aimed to establish a stable and effective model of estrous cycle disorder in female rats induced by long-term heat stress to study its physiological and pathological characteristics and explore the underlying mechanism. In the present study, female Sprague-Dawley rats with normal estrous cycles were exposed to the temperature of 38±0.5°C, relative humidity (RH) of 55±5% (2 h/d, 1 time/d) hot cabin at more than 90 days. Consequently, after long-term heat stress, no difference was detected in body weight and rectal temperature, but the estrus cycle was prolonged, the uterine organ index was increased, pathological changes occurred, the increase latitude of stress hormones heat shock protein 70 (Hsp70) and corticosterone (CORT) decreased, estradiol (E2) and luteinizing hormone (LH) levels decreased, follicle stimulating hormone (FSH) and prolactin (Prl) levels increased, gonadotropin-releasing hormone (GnRH) and thyroid hormone (T4) showed no difference, and insulin (INS) decreased significantly. Moreover, the mRNA expression of the sex hormone receptor in the uterus and ovary was altered. Therefore, the estrous cycle disorder in female rats can be induced by regular heat stress for 90 days, which can be considered the pioneer method. Subsequently, prominent physiological and pathological characteristics and disruption in the hypothalamic-pituitary-gonadal (HPG) axis were noted.

show abstract

mentioning

confidence: 99%

Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress

An¹,

Chen²,

Li³

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…e system (Matvere et al, 2019). FSH is known to stimulate the maturation of ovarian follicles (Wang et al, 2014).…”

Section: Effect Of Sex Hormones On Follicular Developmentmentioning

confidence: 99%

Follicular development in livestock: Influencing factors and underlying mechanisms

Zhang

Gong

et al. 2021

Animal Science Journal

View full text Add to dashboard Cite

Livestock farming development has become increasingly important in recent years. It not only provides us with meat nutrition and pet feeding but also increases the economic value by providing numerous employment opportunities, which improves our life quality. The livestock farming development depends on successful animal reproduction. As a vital process in animal reproduction, folliculogenesis and its influencing factors as well as their underlying mechanisms need to be understood thoroughly. This review is aimed at summarizing the factors such as cellular processes, gene regulation, noncoding RNAs and other endocrine or paracrine regulatory factors that affect follicular development, and their underlying mechanisms of action in livestock in order to provide novel insights for future studies. The above factors were found as significant determinants influencing the follicular development in livestock through various signaling pathways.

show abstract

“…In Figure 1 , we show some proteins and ligands whose activity is modulated by AhR. Among them are AhR’s own repressor AhRR [ 31 ], the transcription factor related to nuclear erythroid factor 2 (NRF2, alias NFE2L2) [ 40 , 41 ], the gamma activated receptor for peroxisome proliferation (PPARG) [ 33 , 34 ], the transforming growth factor-beta (TGF-β) [ 42 ], interleukins (IL6, IL2, IL4, IL10) [ 43 ], NAD(P)H dehydrogenase (quinone) 1 (NQO1) [ 44 ], and indolamine 2,3-dioxygenase (IDO1) [ 20 ], among others.…”

Section: Physiological Functions Of Ahrmentioning

confidence: 99%

Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators

Serna

Cespedes

Viña

2020

IJMS

View full text Add to dashboard Cite

The vast majority of the literature on the aryl hydrocarbon receptor is concerned with its functions in xenobiotic detoxification. However, in the course of evolution, this receptor had to have physiological (rather than toxicological) functions. Our aim was to review the aryl hydrocarbon receptor’s role in the physiological functions involved in aging. This study was performed by searching the MEDLINE and Google Academic databases. A total of 34 articles were selected that focused specifically on the aryl hydrocarbon receptor and aging, the aryl hydrocarbon receptor and physiological functions, and the combination of both. This receptor’s main physiological functions (mediated by the modulation of gene expression) were cell regeneration, the immune reaction, intestinal homeostasis, and cell proliferation. Furthermore, it was shown that the loss of this receptor led to premature aging. This process may be caused by the dysregulation of hematopoietic stem cells, loss of glucose and lipid homeostasis, increase in inflammation, and deterioration of the brain. We conclude that the aryl hydrocarbon receptor, apart from its well-established role in xenobiotic detoxication, plays an important role in physiological functions and in the aging process. Modulation of the signaling pathway of this receptor could be a therapeutic target of interest in aging.

show abstract

FSH/LH-Dependent Upregulation of Ahr in Murine Granulosa Cells Is Controlled by PKA Signaling and Involves Epigenetic Regulation

Cited by 17 publications

References 78 publications

Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress

Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress

Follicular development in livestock: Influencing factors and underlying mechanisms

Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators

Contact Info

Product

Resources

About