FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis

Abstract

Periapical bone loss is one of the prominent pathological and clinical features of periapical periodontitis. Previous studies have demonstrated that follicle-stimulating hormone (FSH) could directly affect skeletal remodelling by stimulating the formation and the function of osteoclasts in vitro and in vivo. However, the effect of FSH on periapical bone loss remained to be fully elucidated. In the current study, a rat model was established in order to verify the effect of FSH in experimental periapical lesions. It was identified that FSH aggravated the bone loss of periapical lesions. In addition, RANKL-, TRAP-, TNF-α- and IL-1β-positive cells were increased significantly in FSH-treated groups, which indicated that the function of FSH in bone loss may be mediated through the increasing activity of osteoclasts and the increased secretion of inflammatory cytokines. The results of the current study suggested that FSH, independent of oestrogen, may aggravate periapical bone loss by FSH receptors, which may serve an important role in the immune and inflammatory response of the host to root canal and periradicular infection during menopause.

Alendronate inhibits osteocyte apoptosis and inflammation via IL‐6, inhibiting bone resorption in periapical lesions of ovariectomized rats

“…Little is known about the expression of proinflammatory cytokines in the periapical lesion of ovariectomized animals. Previous studies have observed that the response to periapical lesion induction in ovariectomized rats was more intense, promoting increased gene expression (Romualdo et al 2018) or immunostaining (Qian et al 2016) of several proinflammatory cytokines, indicating that microbial infection combined with OVX plays an important role in the immunoinflammatory response in the periapical lesion. According to Yang et al (2015), the addition of ALN in osteoclast cell culture causes anti-inflammatory effects, inhibiting IL-1b, IL-6, PGE2 and TNF-a.…”

“…) or immunostaining (Qian et al . ) of several proinflammatory cytokines, indicating that microbial infection combined with OVX plays an important role in the immunoinflammatory response in the periapical lesion. According to Yang et al .…”

Follicle‐stimulating hormone impairs dental pulp stem cells odontogenic differentiation

“…However, only ovariectomy model was unable to highlight the roles of FSH. Our group administered FSH and its inhibitor based on OVX model to study the independent role of FSH 18,20 . No obvious changes were found in E2 levels of OVX groups after FSH and LE application.…”

Roles of Follicle-Stimulating Hormone on Bone Metabolism in Late Postmenopausal Women

“…Follicle-stimulating hormone (FSH) plays a role as a reproductive hormone. However, several studies have suggested the probable extragonadal effects of FSH on bone mass [1][2][3][4][5][6][7][8][9][10][11][12][13][14] and body mass. [15,16] Traditionally, increased bone resorption during menopause has been attributed to reduced estrogen levels.…”

“…[1][2][3][4]6,8,17] Sun et al [1] reported that, irrespective of the nature or severity of estrogen deficiency, high FSH levels are prerequisites for hypogonadal bone loss. Multiple animal studies have demonstrated that FSH aggravates bone loss, [14,18] and that inhibiting FSH is osteoprotective. [19,20] Likewise in humans, the Study of Women's Health Across the Nation (SWAN) found a negative correlation between serum FSH levels and BMD in perimenopausal women.…”