Frustraevo: A Web Server To Localize And Quantify The Conservation Of Local Energetic Frustration In Protein Families
R. Gonzalo Parra,
Maria I. Freiberger,
Miriam Poley-Gil
et al.
Abstract:According to the Principle of Minimal Frustration, folded proteins can have only a minimal number of strong energetic conflicts in their native states. However, not all interactions are energetically optimized for folding but some remain in energetic conflict, i.e. they are highly frustrated. This remaining local energetic frustration has been shown to be statistically correlated with distinct functional aspects such as protein-protein interaction sites, allosterism and catalysis. Fuelled by the recent breakth… Show more
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