Fruit Polyphenols: A Review of Anti-inflammatory Effects in Humans

Joseph, Shama; Edirisinghe, Indika; Burton‐Freeman, Britt

doi:10.1080/10408398.2013.767221

Cited by 220 publications

(140 citation statements)

References 169 publications

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“…This study is the first study to observe the postprandial glycemic control independent of the fiber content in strawberry [31]. Several other studies have also shown beneficial effects of strawberry that may be relevant in providing significant benefits for reducing transition to diabetes or managing existing diabetes [13,32]. Collectively this work with strawberries is promising and supports further studies to understand the mechanisms on insulin signaling and protocols for chronic intake.…”

Section: Enhancing Peripheral Tissue Insulin Sensitivity: Modificatiosupporting

confidence: 55%

“…However, consumers know them as small edible fruits that are brightly colored of red-blue-purple and do not have a pit, although they may contain seeds [13]. Despite the contrasting definitions, berry fruits are a rich source of polyphenols.…”

Section: Polyphenolic Compounds In Berry Fruitsmentioning

confidence: 99%

“…Among the possible factors, oxidative stress and inflammation play a significant role in impaired insulin signaling. Berry fruits, a rich source of polyphenolic compounds have been consistently shown to reduce oxidative stress and inflammation [13,27].…”

Section: Enhancing Peripheral Tissue Insulin Sensitivity: Modificatiomentioning

confidence: 99%

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Anti-diabetic actions of Berry polyphenols – Review on proposed mechanisms of action

Edirisinghe

Burton‐Freeman

2016

JBR

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Abstract. The incidence of type 2 diabetes mellitus (T2DM) has reached near-epidemic proportions in the Western world with other parts of the world following close behind. Glycemic control is paramount in type 1 diabetes mellitus (T1DM) and T2DM. Berries may beneficially influence glycemic control through the action of their polyphenolic components. While clinical studies on the anti-diabetic effects of berry polyphenols are limited, epidemiological data have indicated favorable effects of berry/anthocyanins intake on development and/or management of T2DM. Furthermore, data derived from in vivo animal studies and in vitro cell culture models are promising. Various molecular targets and modulation of cell signaling pathways in pancreatic ␤-cells, hepatocytes, adipocytes, and skeletal muscle cells are among the proposed mechanisms for berry polyphenols and their metabolites' action. Berry polyphenols may exert anti-diabetic effects by (i) enhancing insulin production and reducing apoptosis and promoting proliferation of pancreatic ␤-cells, (ii) regulating glucose metabolism by interfering with absorption or by increasing peripheral tissue glucose uptake through insulin receptor-dependent or independent mechanisms via modification of oxidative stress, inflammation or perceived energy status of cell. This mini review discusses recent findings from our laboratory and other studies on the anti-diabetic effects of berry polyphenolic compounds with special emphasis on the cellular and molecular mechanisms involved in the beneficial effects of berry polyphenol compounds.

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Section: Enhancing Peripheral Tissue Insulin Sensitivity: Modificatiosupporting

confidence: 55%

Section: Polyphenolic Compounds In Berry Fruitsmentioning

confidence: 99%

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Anti-diabetic actions of Berry polyphenols – Review on proposed mechanisms of action

Edirisinghe

Burton‐Freeman

2016

JBR

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“…Inflammation underlies many vascular complications in diabetes and contributes to atherosclerotic CVD [25]. Fruit polyphenols, especially those found in berries, grapes and oranges have demonstrated anti-inflammatory effects in several acute and chronic feeding studies as reviewed by Joseph et al [26]. In this review, several postprandial studies involving fruit and wine polyphenols with or without meal challenge were shown to decrease postprandial inflammation, such as by decreasing CRP, IL-6, IL-1β, TNF-α, PAI-1 and adhesion molecules in mostly healthy, overweight but non-diabetic adults [26].…”

Section: Discussionmentioning

confidence: 99%

Raspberries Improve Postprandial Glucose and Acute and Chronic Inflammation in Adults with Type 2 Diabetes

et al. 2019

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Background: Postprandial metabolic impairments in diabetes have been shown to play an important role in vascular complications. Dietary polyphenols and other bioactive compounds in berries have been shown to improve postprandial hyperglycemia and related metabolic impairments, but few clinical studies have been reported in diabetes. Objective: To examine the effects of daily dietary raspberries on postprandial and 4-week fasting glucose, lipids and biomarkers of inflammation in obese adults with type 2 diabetes. Design: This was a randomized crossover study with 2 different phases: a “postprandial phase” of acute raspberry supplementation (2 separate days at least 1 week apart), followed by a 1-week washout phase and then a 10-week “diet supplement phase”, with and without raspberry supplementation periods of 4 weeks each, separated by 2-week washout phase. Results: The postprandial phase revealed significantly lower levels of serum glucose at 2 and 4 h postprandial after raspberry versus control phase. In addition, among the serum biomarkers of inflammation, interleukin (IL)-6 and high-sensitivity tumor necrosis factor alpha (hsTNF-α) were also lower at 4 h postprandial following raspberry versus control meal (all p < 0.05). Finally, postprandial serum triglycerides showed a decreasing trend at 4 h in the raspberry versus control phase. Four-week daily raspberry supplementation continued to show a significant lowering effects on IL-6 and hsTNF-α versus control phase (all p < 0.05); systolic blood pressure revealed a decreasing trend after 4-week of raspberry supplementation. No effects were noted on fasting glucose and lipids, C-reactive protein and arterial elasticity. Conclusions: Thus, dietary raspberries, which are low in calories and high in polyphenols and other nutrients may lower postprandial hyperglycemia and inflammation, and in general exert selected anti-inflammatory effects in adults with diabetes. These findings deserve further investigation.

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“…Apart from energetics, oxidation supports immunological integrity. While the bulk of epidemiological evidence supports the nutritional/health value of fruits and vegetables [4,11,12,19,22,33,39,40,50], the doses of individual components they contain, such as specific antioxidants that may contribute to improved health and reduced risk of certain diseases, remain uncertain.…”

Section: Flavonoids -From Biosynthesis To Human Health 206mentioning

confidence: 99%

Antioxidant Capacity of Anthocyanin Pigments

Martín¹,

Kuskoski²,

Navas³

et al. 2017

Flavonoids - From Biosynthesis to Human Health

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Anthocyanins are a family of natural pigments classified into the group of flavonoids, considered to be responsible for the color and taste of many fruits and vegetables, i.e. berries. Anthocyanins are common components of the human diet. Besides their interest as colorant because of their coloring properties, the study of anthocyanin compounds stems from their wide applicability in the prevention and even in the treatment of various human diseases. However, various aspects of the pharmacological roles of anthocyanins remain in the dark, having still several obstacles to the development of robust diets or prescribing lines on consumption of anthocyanins. The chemical structure of anthocyanins determines in large measure its capacity and efficacy as an antioxidant agent. In this study, the following aspects are reviewed: the antioxidant effect of anthocyanin pigments; the oxidative stress, the bioavailability after intake and biological aspects of anthocyanins, the method for measuring the antioxidant activity of anthocyanins, the relationship between structure and activity; and the influence of the anthocyanins in the antioxidant activity of wines. Finally an overview of some potential uses in food industry is attempted mainly focusing in the anthocyanin encapsulation topic. Attention has been paid to the more recent publications in the field.

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Fruit Polyphenols: A Review of Anti-inflammatory Effects in Humans

Cited by 220 publications

References 169 publications

Anti-diabetic actions of Berry polyphenols – Review on proposed mechanisms of action

Anti-diabetic actions of Berry polyphenols – Review on proposed mechanisms of action

Raspberries Improve Postprandial Glucose and Acute and Chronic Inflammation in Adults with Type 2 Diabetes

Antioxidant Capacity of Anthocyanin Pigments

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