Fruit and vegetable consumption and risk of bladder cancer

Liu, Huan; Wang, Xingchun; Hu, Guanghui; Guo, Zhuifeng; Lai, Peng; Xu, Liang; Huang, Ting; Xu, Yunfei

doi:10.1097/cej.0000000000000119

Cited by 41 publications

(21 citation statements)

References 46 publications

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“…We measured lower levels of avocadyne 4-acetate and 1-acetoxy-2-hydroxy-16-heptadecen-4-one in the urine from patients with NMIBC than in the urine from healthy controls. Both of these metabolites are members of the class of compounds known as long-chain fatty alcohols, which are present in fruits, supporting the impact of dietary habits on BC ( 27 , 28 ).…”

Section: Discussionmentioning

confidence: 70%

Metabolomics of Non-muscle Invasive Bladder Cancer: Biomarkers for Early Detection of Bladder Cancer

Cheng

Liu

et al. 2018

Front. Oncol.

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Background: Clinical outcomes of bladder cancer (BC) are tightly associated with the stage and grade of the initial diagnosis of BC because early detection is clearly important for patients with BC. However, the diagnostic capability of current detection methods, such as urinary cytology, cystoscopy, imageology method, and several urine-based tests, is inadequate for early detection of BC. The objective of our study is to discover novel biomarkers for detecting BC at an early stage, called non-muscle invasive (NMI) BC, using liquid chromatography-high resolution mass spectrometry (LC-HRMS)-based metabolomics.Methods: First, morning midstream urine samples were collected from healthy adult and NMIBC patients. The LC-HRMS-based metabolomics were applied to distinguish the NMIBC group without hematuria from the controls (gender- and age-matched volunteers with normal clinically healthy index), low-grade NMIBC from the controls, and high-grade from low-grade NMIBC.Results: A total of 284 subjects were enrolled in our study including 117 healthy adults, 80 NMIBC patients without hematuria, and 87 NMIBC patients with hematuria. The metabolite panel including dopamine 4-sulfate, MG00/1846Z,9Z,12Z,15Z/00, aspartyl-histidine, and tyrosyl-methionine was found in a discovery set, which showed the predictive ability to distinguish the NMIBC group from the control group with an area under the curve (AUC) of 0.838 in an external validation set. The AUC of the panel for low-grade NMIBC samples, which consisted of 3-hydroxy-cis-5-tetradecenoylcarnitine, 6-ketoestriol, beta-cortolone, tetrahydrocorticosterone, and heptylmalonic acid, was 0.899. The sensitivity and specificity were 0.881 and 0.786, respectively. The AUC of the panel for distinction of low-grade NMIBC with and without hematuria against high-grade NMIBC with and without hematuria were 0.827 and 0.755, respectively. In addition, metabolites involved in tryptophan metabolism were upregulated in the urine of high-grade NMIBC patients when compared with low-grade NMIBC patients with the presence or absence of hematuria.Conclusion: The NMIBC urine metabolic profiling was able to assist in the early detection of BC. Panels of metabolites were discovered to have a potential value for high-grade NMIBC and low-grade NMIBC diagnosis as well as for NMIBC grading distinction.

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Section: Discussionmentioning

confidence: 70%

Metabolomics of Non-muscle Invasive Bladder Cancer: Biomarkers for Early Detection of Bladder Cancer

Cheng

Liu

et al. 2018

Front. Oncol.

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“…The role of diet on bladder carcinogenesis may be mediated by many metabolites of foods, which are excreted through the urinary tract. Previous studies—although not all—on bladder cancer have shown a protective role of high intakes of fruit and vegetables and selected nutrients related to these foods [ 11 , 37 ]. A favorable effect on bladder cancer of olive oil has also been suggested [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Mediterranean Diet and Bladder Cancer Risk in Italy

et al. 2018

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Previous studies have reported that Mediterranean diet is inversely related to the risk of several neoplasms; however, limited epidemiological data are available for bladder cancer. Thus, we examined the association between Mediterranean diet and this neoplasm in an Italian multicentric case-control study consisting of 690 bladder cancer cases and 665 controls. We assessed the adherence to the Mediterranean diet via a Mediterranean Diet Score (MDS), which represents the major characteristics of the Mediterranean diet and ranges from 0 to 9 (from minimal to maximal adherence, respectively). We derived odds ratios (ORs) of bladder cancer according to the MDS score from multiple logistic regression models, allowing for major confounding factors. The ORs of bladder cancer were 0.72 (95% confidence interval, CI, 0.54–0.98) for MDS of 4–5 and 0.66 (95% CI, 0.47–0.93) for MDS of 6–9 (p for trend = 0.02) compared to MDS = 0–3. Results were similar in strata of sex, age, and education, while the risk appeared somewhat lower in never-smokers and patients with pT1–pT4 bladder carcinomas. Among individual components of the MDS, we observed inverse associations for greater consumption of legumes, vegetables, and fish. In our study, which was carried out on an Italian population, the higher adherence to the Mediterranean diet was related to a lower risk of bladder cancer.

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“…Total participants 56 005 (9) 64 866 (11) 49 457 825 268 445 204 (8) 37 102 (6) 33 856 (6) 40 782 749 328 (8) 75 035 (13) 5632 138 263 6 33 856 825 343 626 782 752 559 (13) 2580 122 465 6 152 4303 9248 7940 (27) 520 15378 (11) 3538 ( approximately three pieces of fruit), using the lowest intake category as a reference. Fruit types (citrus fruits, soft fruits, stone fruits, tropical fruits, pome fruits and fruit products) were each analysed as a continuous variable per 25 g of fruits per day increase and were modelled into quartiles, using the lowest quartile as a reference.…”

Section: Discussionmentioning

confidence: 99%

Fruit consumption and the risk of bladder cancer: A pooled analysis by the Bladder Cancer Epidemiology and Nutritional Determinants Study

Jochems

Reulen

Osch

et al. 2020

Intl Journal of Cancer

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While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by pooling individual data from 13 cohort studies. Cox regression models with attained age as time scale were used to estimate hazard ratios (HRs) for intakes of total fruit and citrus fruits, soft fruits, stone fruits, tropical fruits, pome fruits and fruit products. Analyses were stratified by sex, smoking status and bladder cancer subtype. During on average 11.2 years of follow‐up, 2836 individuals developed incident bladder cancer. Increasing fruit consumption (by 100 g/day) was inversely associated with the risk of bladder cancer in women (HR = 0.92; 95% CI 0.85‐0.99). Although in women the association with fruit consumption was most evident for higher‐risk nonmuscle invasive bladder cancer (NMIBC; HR = 0.72; 95% CI 0.56‐0.92), the test for heterogeneity by bladder cancer subtype was nonsignificant (P‐heterogeneity = .14). Increasing fruit consumption (by 100 g/day) was not associated with bladder cancer risk in men (HR = 0.99; 95% CI 0.94‐1.03), never smokers (HR = 0.96; 95% CI 0.88‐1.05), former smokers (HR = 0.98; 95% CI 0.92‐1.05) or current smokers (HR = 0.95; 95% CI 0.89‐1.01). The consumption of any type of fruit was not found to be associated with bladder cancer risk (P values > .05). Our study supports no evidence that the consumption of specific types of fruit reduces the risk of bladder cancer. However, increasing total fruit consumption may reduce bladder cancer risk in women.

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Fruit and vegetable consumption and risk of bladder cancer

Cited by 41 publications

References 46 publications

Metabolomics of Non-muscle Invasive Bladder Cancer: Biomarkers for Early Detection of Bladder Cancer

Metabolomics of Non-muscle Invasive Bladder Cancer: Biomarkers for Early Detection of Bladder Cancer

Mediterranean Diet and Bladder Cancer Risk in Italy

Fruit consumption and the risk of bladder cancer: A pooled analysis by the Bladder Cancer Epidemiology and Nutritional Determinants Study

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