Fruit and Vegetable Consumption and Its Relation to Markers of Inflammation and Oxidative Stress in Adolescents

Holt, Erica M.; Steffen, Lyn M.; Moran, Antoinette; Basu, Samar; Steinberger, Julia; Ross, Julie A.; Hong, Ching Ping; Sinaiko, Alan R.

doi:10.1016/j.jada.2008.11.036

Cited by 388 publications

(325 citation statements)

References 75 publications

(75 reference statements)

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“…Specifically, the consumption of fruit or vegetables, or the intake of vitamin C and β ‐carotene is inversely associated with pro‐inflammatory markers in adolescents (Holt et al. 2009). …”

Section: Resultsmentioning

confidence: 99%

Efficacy of nutritional interventions to lower circulating ceramides in young adults: FRUVEDomic pilot study

et al. 2017

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The 2010 USDA Dietary Guidelines for Americans (DGA) recommends a diet largely composed of fruit and vegetables. Consuming a diet high in fruit and vegetables and low in refined carbohydrates and saturated fat may reduce an individual's risk for type 2 diabetes, nonalcoholic fatty liver disease, low‐grade chronic inflammation, and metabolic syndrome (MetS). Several recent studies have implicated the bioactive sphingolipid ceramide as an associative and causative biomarker for the development of these conditions. Considering that the intake of fruit and vegetables is frequently inadequate in young adults, we performed a pilot investigation to assess the efficacy of a free‐living fruit and vegetable intervention on overall metabolic health, circulating ceramide supply, and inflammatory status in young adults. We discovered that adoption of the recommended DGA for fruit and vegetable intake for 8 weeks decreased waist circumference, systolic blood pressure, and circulating cholesterol. Lipidomics analysis revealed that nutritional intervention can lower circulating ceramides, including C24:0 ceramide, a known inhibitor of insulin signaling. Unexpectedly, we observed an increase in C16:0 ceramide, suggesting that this form of ceramide in circulation is not associated with metabolic disease in humans. We also observed an improved inflammatory status with enhanced fruit and vegetable intake that was correlated with ceramide concentrations. These data suggest that adopting the recommended DGA is associated with a reduction of many, but not all, ceramide species and may help to prevent or mitigate MetS. Future research needs to assess whether the ceramide‐lowering ability of nutritional intervention is associated with reduced risk of developing metabolic disease.

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Section: Resultsmentioning

confidence: 99%

Efficacy of nutritional interventions to lower circulating ceramides in young adults: FRUVEDomic pilot study

et al. 2017

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“…Many epidemiological studies suggest that consumption of a fruit-and vegetable-rich diet inversely correlates with the risk of chronic diseases. These chemoprotective effects are, at least in part, related to the antioxidant activities of phenolic compounds (Holt et al, 2009;Naelsen, Basu, Wolk, & Vessby, 2006).…”

Section: Cuprac Assaymentioning

confidence: 99%

“…A fruit-and vegetable-rich diet has also been inversely correlated with reduced inflammation (Holt et al, 2009). Platelet activating factor (PAF) identified as 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (Demopoulos, Pinckard, & Hanahan, 1979) has been recognized as one of the most potent lipid inflammatory and thrombotic mediator that activates various cells through its specific receptor, such as platelets (Demopoulos et al, 2003).…”

Section: In Vitro Anti-thrombotic/antiinflammatory Activitymentioning

confidence: 99%

In vitro health beneficial activities of Pumpkin seeds from Cucurbita moschata cultivated in Lemnos

Sakka

Karantonis

2015

IJFS

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Pumpkin seeds are commonly consumed in Greece. Although Cucurbita moschata is locally grown in Lemnos and is traditionally used in pumpkin pies, the seeds are currently discarded after consumption of the fruit flesh. The aim of the present study was to investigate the nutritional functionality of pumpkin seeds from Cucurbita moschata grown in Lemnos. Cucurbita moschatas' seeds, raw or roasted, were appropriately extracted and the results are presented for raw versus (vs) roasted seed extracts. The phenolic content was expressed as µg gallic acid/g of seeds according to Folin-Ciocalteau assay (370.3 ± 19.1 vs 551.0 ± 22.0). Antioxidant capacity was expressed as equivalent amount for 50% scavenging in mg of seeds for DPPH (50.03 ± 5.91 vs 25.82 ± 6.77) and ABTS (17.85 ± 0.77 vs 12.77 ± 0.76) assays, and as µmol of trolox/g of seeds for FRAP (1.19 ± 0.05 vs 2.50 ± 0.23) and CUPRAC (2.13 ±0.11 vs 3.25 ± 0.06) assays. Anti-inflammatory/antithrombotic and anti-diabetic activities were expressed as mg of seeds for 50% inhibition of platelet activating factor (0.62 vs 0.15) and as µg of seeds for 25% inhibition of alpha-glycosidase (40.0 vs 61.0) activities respectively. Moreover, anti-atherogenic activity was expressed as the % increase in lag time of human plasma oxidation (62.7 versus 163.2) Raw and roasted pumpkin seed extracts exert anti-oxidant, anti-thrombotic/anti-inflammatory, antiatherogenic and antidiabetic activities. Cucurbita moschata seeds may represent a novel opportunity for development of functional foods, with a local interest in Lemnos that would contribute also to the regional public health improvement.

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“…Among the protective mechanisms including protective enzymes, antioxidant or quenching compounds produced by the organism, and similar compounds made available in the diet, the primary defensive compounds are antioxidants, such as vitamin C, vitamin E, b-carotene, and flavonoids and so on, that can react with quench reactive radical species (Institute of Medicine, 2000). Also, food intake has been related to oxidative stress modulation and controlling antioxidant intake has been reported to protect against oxidative damage and related inflammatory complications (Holt et al, 2009). Many functional biomarkers are being studied including various measures of lipid, DNA and protein oxidation.…”

Section: Introductionmentioning

confidence: 99%

Diet quality scores and oxidative stress in Korean adults

Kim

Yang

et al. 2011

Eur J Clin Nutr

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Background/Objectives: The purpose of diet-quality indices is to assess and guide individual dietary intake for the promotion of health and prevention of disease, and food based dietary-quality indices need to be applied by using each country's own unique diet. We assessed the relationships between relatively simple dietary quality scores modified for a Korean diet, such as the Recommended Food Score (RFS) and alternate Mediterranean Diet Score (aMDS), and oxidative stress biomarkers in Korean adults. Subjects/Methods: A total of 976 adults were recruited for the Biomarker Monitoring for Environmental Health Study between April and December 2005 in Seoul and Incheon, Korea. RFS and aMDS were calculated by using a food-frequency questionnaire. We used regression analyses to assess the associations between diet quality scores and urinary malondialdehyde (MDA) and 8-hydroxy-2 0 -deoxyguanosine (8-OHdG). Results: RFS and aMDS were negatively associated with urinary MDA concentrations (P ¼ 0.032 for RFS, P ¼ 0.043 for aMDS), but not with 8-OHdG after adjusted for potential covariates. After stratified analyses by sex, negative associations between the both scores and urinary MDA concentrations were not significant in both men and women. There were no significant associations of RFS and aMDS with urinary 8-OHdG concentrations. Conclusions: Higher RFS and aMDS scores were related to lower oxidative stress. Therefore, good quality of diet may be useful in reducing oxidative stress.

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Fruit and Vegetable Consumption and Its Relation to Markers of Inflammation and Oxidative Stress in Adolescents

Cited by 388 publications

References 75 publications

Efficacy of nutritional interventions to lower circulating ceramides in young adults: FRUVEDomic pilot study

Efficacy of nutritional interventions to lower circulating ceramides in young adults: FRUVEDomic pilot study

In vitro health beneficial activities of Pumpkin seeds from Cucurbita moschata cultivated in Lemnos

Diet quality scores and oxidative stress in Korean adults

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