Fructose malabsorption in people with and without gout: A case–control study

Batt, Caitlin; Fanning, Niamh; Drake, Jill; Frampton, Christopher; Gearry, Richard B.; Stamp, Lisa K.

doi:10.1016/j.semarthrit.2017.03.018

Cited by 1 publication

(1 citation statement)

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“…Fructose malabsorption in humans increases with fructose intake concentration and in healthy adults, there is a significant positive relationship between fructose dose and the breath test result (13) . In healthy volunteers, after 15, 25, 35 and 50 g fructose loads, breath tests were positive in 0, 10, 52 and 65 % of the individuals tested, respectively (Table 1) (74,75) . In healthy subjects the absorption of 15 to 25 g of fructose was not associated with malabsorption signs, suggesting that the intestinal absorptive capacity for fructose is about 25 g per food intake (75) .…”

Section: Fructose Breath Testmentioning

confidence: 98%

Fructose and irritable bowel syndrome

et al. 2020

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Irritable bowel syndrome (IBS) is a chronic disorder characterised by recurrent abdominal pain or discomfort and transit disturbances with heterogeneous pathophysiological mechanisms. The link between food and gastrointestinal (GI) symptoms is often reported by patients with IBS and the role of fructose has recently been highlighted. Fructose malabsorption can easily be assessed by hydrogen and/or methane breath test in response to 25 g fructose; and its prevalence is about 22 % in patients with IBS. The mechanism of fructose-related symptoms is incompletely understood. Osmotic load, fermentation and visceral hypersensitivity are likely to participate in GI symptoms in the IBS population and may be triggered or worsened by fructose. A low-fructose diet could be integrated in the overall treatment strategy, but its role and implication in the improvement of IBS symptoms should be evaluated. In the present review, we discuss fructose malabsorption in adult patients with IBS and the interest of a low-fructose diet in order to underline the important role of fructose in IBS.

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