Fructose impairs glucose-induced hepatic triglyceride synthesis

Huang, Danshan; Dhawan, Tania; Young, Stephen G.; Yong, William H.; Boros, László G.; Heaney, Anthony P.

doi:10.1186/1476-511x-10-20

Cited by 39 publications

(35 citation statements)

References 50 publications

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“…Previous studies have found that higher TAG levels may be caused by high consumption of refined carbohydrates, fructose or fat (24) ; however, generally, vegetarians in our study, consumed lower amounts of sugary drinks, sweet bread and fried food and, except for lacto-ovo-vegetarians, higher amounts of vegetables and whole grains (healthier type of carbohydrates). Lacto-ovo-vegetarians appeared to eat more carbohydrates and fructose, which could be one of the main causes for TAG elevation in this group.…”

Section: Discussioncontrasting

confidence: 68%

Cross-sectional and longitudinal comparisons of metabolic profiles between vegetarian and non-vegetarian subjects: a matched cohort study

et al. 2015

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Several previous cross-sectional studies have shown that vegetarians have a better metabolic profile than non-vegetarians, suggesting that a vegetarian dietary pattern may help prevent chronic degenerative diseases. However, longitudinal studies on the impact of vegetarian diets on metabolic traits are scarce. We studied how several sub-types of vegetarian diets affect metabolic traits, including waist circumference, BMI, systolic blood pressure (SBP), diastolic blood pressure, fasting blood glucose, total cholesterol (TC), HDL, LDL, TAG and TC:HDL ratio, through both cross-sectional and longitudinal study designs. The study used the MJ Health Screening database, with data collected from 1994 to 2008 in Taiwan, which included 4415 lacto-ovo-vegetarians, 1855 lacto-vegetarians and 1913 vegans; each vegetarian was matched with five non-vegetarians based on age, sex and study site. In the longitudinal follow-up, each additional year of vegan diet lowered the risk of obesity by 7 % (95 % CI 0·88, 0·99), whereas each additional year of lacto-vegetarian diet lowered the risk of elevated SBP by 8 % (95 % CI 0·85, 0·99) and elevated glucose by 7 % (95 % CI 0·87, 0·99), and each additional year of ovo-lacto-vegetarian diet increased abnormal HDL by 7 % (95 % CI 1·03, 1·12), compared with non-vegetarians. In the cross-sectional comparisons, all sub-types of vegetarians had lower likelihoods of abnormalities compared with non-vegetarians on all metabolic traits (P < 0·001 for all comparisons), except for HDL and TAG. The better metabolic profile in vegetarians is partially attributable to lower BMI. With proper management of TAG and HDL, along with caution about the intake of refined carbohydrates and fructose, a plant-based diet may benefit all aspects of the metabolic profile.

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Section: Discussioncontrasting

confidence: 68%

Cross-sectional and longitudinal comparisons of metabolic profiles between vegetarian and non-vegetarian subjects: a matched cohort study

et al. 2015

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“…Hypertriglyceridemia occurs because high fructose in the blood leads to increased de novo hepatic fatty acid synthesis and, subsequently, this releases a high amount of TG [21]. The E. longifolia root extract used in our study reduced TG levels induced by glucose-fructose enrich diet.…”

Section: Discussionmentioning

confidence: 73%

Evaluation of Antihyperlipidemic, Anti-Inflammatory, and Analgesic Activities of Eurycoma Longifolia in Animal Models

Hendra

Fenty

Andreani

et al. 2017

Int J Pharm Pharm Sci

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Objective: To investigate the anti-hyperlipidemic, anti-inflammatory and analgesic properties of of E. longifolia root extract in animal models. Methods:In this study, glucose-fructose enriched diet-induced hyperlipidemia, carrageenan-induced paw edema and acetic acid-induced writhing were used to evaluate the anti-hypertriglyceridemia, anti-inflammatory and analgesic activities, respectively. At the end of the experiment of glucose-fructose enriched diet-induced hyperlipidemia, blood samples were collected and estimation of blood lipids were carried out. Edema thickness was measured using digital caliper at 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330, and 360 min after carrageenan injection. The number of abdominal writhing for each mouse was observed and counted during a period of 1 h post injection of acetic acid.Results: E. longifolia root extract demonstrated a significant reduction of triglyceride levels (p<0.05) compared with the control group in glucosefructose enrich diet in rats. In anti-inflammatory test, the extract significantly inhibited the carrageenan induced paw edema formation (p<0.05). The extract also significantly decreased the number of writhing in acetic acid-induced mice (p<0.05).Conclusion: E. longifolia root extract shown a significant anti-hypertriglyceridemia, anti-inflammatory and analgesic activities. Further studies are needed to determine mechanisms for its acitivities of E. longifolia root extract.

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“…Elevated triglyceride levels may inhibit the transport of leptin across the blood-brain barrier of rodents 30 , and high-fructose diets (60%) induced hepatic triglycerides synthesis 31 and hypothalamic leptin resistance 32 , so there is a relation between dietary fructose and leptin. The study animals fed the HFr or HFat diet had hypertriglyceridemia and low levels of leptin expression in the brain.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary high fructose corn syrup on regulation of energy intake and leptin gene expression in rats

et al. 2015

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OBJECTIVE: To evaluate in Wistar rats the effect of chronic use of high fructose corn syrup on serum lipids, body weight, energy intake regulation, and expression of associated genes. METHODS: For 11 weeks, male rats were fed a standard diet with either water (control) or 15% high fructose corn syrup solution, or fed a high-fat diet. The rats' food intake and body weight were measured weekly. Expression of leptin and fatty acid synthase genes was quantified in their brain and adipose tissue upon sacrifice at age 119 days using real-time polymerase chain reaction. RESULTS: The intake of 15% high fructose corn syrup did not affect the rats' weight, only the rats on the high-fat diet gained significant weight. The rats in both diets had lower levels of leptin expression and high levels of fatty acid synthase in the brain, which were associated with high serum triglycerides. CONCLUSION: Fifteen percent high fructose corn syrup intake and the high-fat diet reduced leptin gene expression in the brain of Wistar rats, with differential effects on weight gain.

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Fructose impairs glucose-induced hepatic triglyceride synthesis

Cited by 39 publications

References 50 publications

Cross-sectional and longitudinal comparisons of metabolic profiles between vegetarian and non-vegetarian subjects: a matched cohort study

Cross-sectional and longitudinal comparisons of metabolic profiles between vegetarian and non-vegetarian subjects: a matched cohort study

Evaluation of Antihyperlipidemic, Anti-Inflammatory, and Analgesic Activities of Eurycoma Longifolia in Animal Models

Effects of dietary high fructose corn syrup on regulation of energy intake and leptin gene expression in rats

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