Fructose diet ameliorates effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice

Abstract

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that represents a link between diet-induced inflammation and insulin resistance. Our aim was to examine whether fructose diet affects inflammation and insulin signaling in the prefrontal cortex (PFC) of Mif knockout mice (MIF-KO), and their possible link to neural plasticity and behavior. We analyzed

Macrophage migration inhibitory factor in acute kidneyinjury

“…MIF exerts its biological activity in the form of homotrimers, with its sequence highly conserved in mammals, and it also exists in bacteria, nematodes, and protozoa. It can be proinflammatory cytokine (Tohyama et al, 2008;Lyu et al, 2021;Schindler et al, 2021;Vrataric et al, 2021), chemokine-like functional chemokine, anterior pituitary hormone, nuclease (Wang Y. et al, 2016), enzyme with tautomerism and thiol protein oxidoreductase (TPOR) activity (Stoppe et al, 2018), in parallel it can also regulate cell proliferation and survival, fibrosis (Sanchez-Nino et al, 2013) and energy metabolism (Gligorovska et al, 2021). Autocrine or paracrine MIF can bind to membrane surface receptor CD74/CD44 (Rice et al, 2003;Ma et al, 2010;Xie et al, 2016;Wang J. et al, 2021) and chemokine receptor CXCR2, CXCR4 and CXCR7 (Bernhagen et al, 2007;Chatterjee et al, 2014;Alampour-Rajabi et al, 2015) to jointly activate downstream signaling pathways such as ERK1/2, MAPK and P53.…”