Fructose consumption as a risk factor for metabolic syndrome and nonalcoholic fatty liver disease

Sheptulina, A.F.; Golubeva, Yu.A.; Drapkina, О. М.

doi:10.17116/dokgastro20231201185

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…В эксперименте, высокое потребление фруктозы (25% и более от общей суточной калорийности рациона) тесно связано с развитием инсулинорезистентности и накоплением висцерального жира, которые лежат в основе формирования метаболического синдрома [17]. В клинике, пациенты с НАЖБП употребляют почти в 2 раза большее количество безалкогольных сладких напитков по сравнению со здоровыми [18]; установлена корреляция между потреблением сладких безалкогольных напитков и ожирением [19,[20][21][22]. Поэтому, использование диеты, перегруженной фруктозой, также является перспетивным направлением разработки моделей НАЖБП с перегрузкой железа.…”

Section: модели перегрузки железом с использованием диет с высоким со...unclassified

Pharmacological models of liver iron overload

Bogacheva,

Torshin,

Gromova

et al. 2024

jour

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Iron deposits in tissues (hemosiderosis) accompany various diseases of the liver and pancreas. Overload of the liver with iron occurs due to (1) a diet with excess saturated fats, which provoke inflammation of the liver, (2) slowdown and stagnation of blood flow in the area of the portal vein (physical inactivity, obesity, alcoholism, etc), (3) uncontrolled and long-term use of iron supplements (primarily based on inorganic forms - sulfates, oxides, hydroxides of iron, etc.), (4) hereditary diseases (hemochromatosis). Patients with liver overload with iron require not only correction of diet and lifestyle (including physical activity), but also special therapy using effective and safe drugs. To study the effect of excess iron on the body and search for the most appropriate therapy for hemosiderosis, special models of liver overload with iron have been developed in pharmacology. The degree of iron overload and the rate of hemosiderosis formation in models can be slowed down by the addition of micronutrients with hepatoprotective properties (vitamins A, C) and accelerated by the addition of saturated fat and/or fructose to the diet.

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Section: модели перегрузки железом с использованием диет с высоким со...unclassified

Pharmacological models of liver iron overload

Bogacheva,

Torshin,

Gromova

et al. 2024

jour

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Diet for gout and hyperuricaemia: some important questions

Zhelyabina,

Eliseev,

Kuzmina

2024

Sovremennaâ revmatologiâ

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Diet has traditionally been viewed as playing a leading role in both the pathogenesis and treatment of gout. And although this thesis is controversial today, adherence to certain dietary rules for patients with gout and hyperuricemia (HU) is an integral part of therapy. The review examines the modern theoretical basis of dietary therapy for gout and HU, in particular the mechanisms of increasing serum uric acid levels and the risk of developing arthritis when certain foods are consumed and, conversely, reducing uric acid levels and the risk of gout when a diet containing a range of vitamins and foods in the supplements is followed.

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Fructose consumption as a risk factor for metabolic syndrome and nonalcoholic fatty liver disease

Cited by 2 publications

References 39 publications

Pharmacological models of liver iron overload

Pharmacological models of liver iron overload

Diet for gout and hyperuricaemia: some important questions

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