“…The enzymes derived from PFKFB1, PFKFB2 and PFKFB4 were originally found to be expressed by cells of the liver/muscle, kidney/heart and testes, respectively, and all display nearly equal kinase: phosphatase ratios (Okar and Lange, 1999). The PFKFB3 gene encodes for the inducible PFK2/FBPase (Chesney et al, 1999;Atsumi et al, 2002;Mahlknecht et al, 2003), which is rapidly induced by inflammatory stimuli (Chesney et al, 1999) and hypoxia (Minchenko et al, 2002;Minchenko et al, 2004) and has also been termed placental PFK2 (Sakai et al, 1996;Sakakibara et al, 1999), ubiquitous PFK2 (Manzano et al, 1998;Kessler and Eschrich, 2001;Navarro-Sabate et al, 2001) and PGR1 (Hamilton et al, 1997)).…”