Fructose-1-kinase has pleiotropic roles inEscherichia coli
Chamitha Weeramange,
Cindy Menjivar,
Pierce T. O’Neil
et al.
Abstract:InEscherichia coli, the master transcription regulator Catabolite Repressor Activator (Cra) regulates >100 genes in central metabolism. Cra binding to DNA is allosterically regulated by binding to fructose-1-phosphate (F-1-P), but the only documented source of F-1-P is from the concurrent import and phosphorylation of exogenous fructose. Thus, many have proposed that fructose-1,6-bisphosphate (F-1,6-BP) is also a physiological regulatory ligand. However, the role of F-1,6-BP has been widely debated. Here, w… Show more
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