Fructose-1,6-bisphosphate aldolase is involved in Mycoplasma bovis colonization as a fibronectin-binding adhesin

Huang, Jing; Zhu, Hongmei; Wang, Jiayao; Guo, Yongpeng; Liu, Yang; Wei, Hao-Hua; Li, Han-Xiong; Liu, Dongming; Chen, Xi

doi:10.1016/j.rvsc.2019.02.010

Cited by 20 publications

(13 citation statements)

References 80 publications

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“…Some multifunctional enzymes including methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (TrmFO), NADH oxidase (NOX), and FBA also found in M. bovis. Among these, TrmFO and FBA are involved in cytadhesion to EBL cells [71][72][73][74]. NOX functions as a membrane-associated adhesin by interacting with amyloid precursor-like protein 2 on EBL cells [75].…”

Section: Adhesins For Pathogenic Mycoplasmas In Avianmentioning

confidence: 99%

Infection strategies of mycoplasmas: Unraveling the panoply of virulence factors

Chen

Qin

et al. 2021

Virulence

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Mycoplasmas, the smallest bacteria lacking a cell wall, can cause various diseases in both humans and animals. Mycoplasmas harbor a variety of virulence factors that enable them to overcome numerous barriers of entry into the host; using accessory proteins, mycoplasma adhesins can bind to the receptors or extracellular matrix of the host cell. Although the host immune system can eradicate the invading mycoplasma in most cases, a few sagacious mycoplasmas employ a series of invasion and immune escape strategies to ensure their continued survival within their hosts. For instance, capsular polysaccharides are crucial for anti-phagocytosis and immunomodulation. Invasive enzymes degrade reactive oxygen species, neutrophil extracellular traps, and immunoglobulins. Biofilm formation is important for establishing a persistent infection. During proliferation, successfully surviving mycoplasmas generate numerous metabolites, including hydrogen peroxide, ammonia and hydrogen sulfide; or secrete various exotoxins, such as communityacquired respiratory distress syndrome toxin, and hemolysins; and express various pathogenic enzymes, all of which have potent toxic effects on host cells. Furthermore, some inherent components of mycoplasmas, such as lipids, membrane lipoproteins, and even mycoplasmagenerated superantigens, can exert a significant pathogenic impact on the host cells or the immune system. In this review, we describe the proposed virulence factors in the toolkit of notorious mycoplasmas to better understand the pathogenic features of these bacteria, along with their pathogenic mechanisms.

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Section: Adhesins For Pathogenic Mycoplasmas In Avianmentioning

confidence: 99%

Infection strategies of mycoplasmas: Unraveling the panoply of virulence factors

Chen

Qin

et al. 2021

Virulence

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“…Moreover, interactions between ECM molecules and bacterial surface proteins have been described for several mycoplasma species, including Mycoplasma pneumoniae, Mycoplasma gallisepticum and Mycoplasma bovis, among others [103][104][105][106][107]. Interestingly, the fibronectin-binding ability of M. hyopneumoniae may mediate the adherence to swine respiratory cilia and can provide a mechanism for host cytoskeleton rearrangements, which may facilitate bacterial internalization [108]. Additionally, the plasminogen-binding ability of M. hyopneumoniae may facilitate its traffic via the circulatory system and penetration into host organs, such as liver, kidneys and spleen, from which it has already been isolated [109,110].…”

Section: Host Cell Adhesion Determinantsmentioning

confidence: 99%

“…However, the demonstration that it binds to fibronectin and plasmin at the site of infection [100,110,119,120], an interaction classically associated to host cell invasion by bacteria [121,122], suggested that it could also penetrate porcine cells. Indeed, it was recently demonstrated that M. hyopneumoniae could invade in vitroinfected host-derived epithelial cells [108]. Host cell invasion is mediated by endocytic pathways, which are initiated by interactions between mycoplasma surface proteins and host fibronectin and integrin β1.…”

Section: Hyopneumoniae Biofilm Formation Host Cell Invasion and Smentioning

confidence: 99%

Pathogenicity & virulence of Mycoplasma hyopneumoniae

et al. 2020

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“…Binding of M. gallisepticum to plasminogen and fibronectin and of M. hyopneumoniae to fibronectin was described by several research groups [81••, 91, 92]. Various fibronectin-binding proteins were also identified for M. bovis [93][94][95][96]. It is supposed that binding to fibronectin acts as a mediating bridge between the pathogen and host cell receptors of the integrin family initiating the uptake in non-phagocytic cells.…”

Section: Cell Invasionmentioning

confidence: 99%

Persistence in Livestock Mycoplasmas—a Key Role in Infection and Pathogenesis

Hoelzle¹,

Ade²,

Hoelzle³

2020

Curr Clin Micro Rpt

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Purpose of Review Mycoplasma, economically important pathogens in livestock, often establishes immunologically complex persistent infections that drive their pathogenesis and complicate prophylaxis and therapy of the caused diseases. In this review, we summarize some of the recent findings concerning cellular and molecular persistence mechanisms related to the pathogenesis of mycoplasma infections in livestock. Recent Findings Data from recent studies prove several mechanisms including intracellular lifestyle, immune dysregulation, and autoimmunity as well as microcolony and biofilm formation and apoptosis of different host cell types as important persistence mechanisms in several clinically significant Mycoplasma species, i.e., M. bovis, M. gallisepticum, M. hyopneumoniae, and M. suis. Summary Evasion of the immune system and the establishment of persistent infections are key features in the pathogenesis of livestock mycoplasmas. In-depth knowledge of the underlying mechanisms will provide the basis for the development of therapy and prophylaxis strategies against mycoplasma infections.

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Fructose-1,6-bisphosphate aldolase is involved in Mycoplasma bovis colonization as a fibronectin-binding adhesin

Cited by 20 publications

References 80 publications

Infection strategies of mycoplasmas: Unraveling the panoply of virulence factors

Infection strategies of mycoplasmas: Unraveling the panoply of virulence factors

Pathogenicity & virulence of Mycoplasma hyopneumoniae

Persistence in Livestock Mycoplasmas—a Key Role in Infection and Pathogenesis

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