Fructosamine and glycated hemoglobin as biomarkers of glycemic control in people with type 2 diabetes mellitus and cancer (GlicoOnco study)

Toyoshima, Marcos Tadashi Kakitani; Cukier, Priscilla; Damascena, Aline Santos; Batista, Rafael Loch; Correa, Fernanda A.; Kawahara, Ei; Minanni, Carlos André; Hoff, Ana O.; Nery, Márcia

doi:10.1016/j.clinsp.2023.100240

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Compared to HbA1c, GSP has higher sensitivity and specificity, making it more accurate for diabetes monitoring in conditions like renal dysfunction and anemia. A study (45) demonstrated a robust positive correlation between fructosamine levels and HbA1c, indicating that fructosamine and HbA1c may serve as useful glycemic biomarkers for patients with concomitant diabetes and cancer, including those undergoing chemotherapy, utilizing glucocorticoids, or with anemia, hypoalbuminemia, or reduced renal function. GSP testing has potential value in early diagnosis of diabetes and diabetic complications (46).…”

Section: Importance Of Early Identificationmentioning

confidence: 99%

Early detection of type 2 diabetes risk: limitations of current diagnostic criteria

Zhang,

Zhang

et al. 2023

Front. Endocrinol.

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Type 2 diabetes (T2D) is the leading cause of diabetes worldwide and is increasing rapidly, especially in youth. It accounts for most diabetes deaths in adults ≥20 years old in the Americas, with type 2 diabetes responsible for most of the disease burden. The incidence and burden of type 2 diabetes in adolescents and young adults have risen in recent decades globally. Countries with lower socioeconomic status had the highest incidence and burden, and females generally had higher mortality and disease burden than males at ages <30 years. Early diagnosis and management are crucial to delaying progression, but current diagnostic criteria based on glucose thresholds and glycated hemoglobin have limitations. Recent analyses show that prediabetes increases cancer risk. Better diagnostic criteria are urgently needed to identify high-risk individuals earlier. This article discusses the limitations of current criteria and explores alternative approaches and future research directions.

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Section: Importance Of Early Identificationmentioning

confidence: 99%

Early detection of type 2 diabetes risk: limitations of current diagnostic criteria

Zhang,

Zhang

et al. 2023

Front. Endocrinol.

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Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis

Patil,

Tupe

2023

Medicinal Research Reviews

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Diabetes and its complications, Alzheimer's disease (AD), and Parkinson's disease (PD) are increasing gradually, reflecting a global threat vis‐à‐vis expressing the essentiality of a substantial paradigm shift in research and remedial actions. Protein glycation is influenced by several factors, like time, temperature, pH, metal ions, and the half‐life of the protein. Surprisingly, most proteins associated with metabolic and neurodegenerative disorders are generally long‐lived and hence susceptible to glycation. Remarkably, proteins linked with diabetes, AD, and PD share this characteristic. This modulates protein's structure, aggregation tendency, and toxicity, highlighting renovated attention. Gut microbes and microbial metabolites marked their importance in human health and diseases. Though many scientific shreds of evidence are proposed for possible change and dysbiosis in gut flora in these diseases, very little is known about the mechanisms. Screening and unfolding their functionality in metabolic and neurodegenerative disorders is essential in hunting the gut treasure. Therefore, it is imperative to evaluate the role of glycation as a common link in diabetes and neurodegenerative diseases, which helps to clarify if modulation of nonenzymatic glycation may act as a beneficial therapeutic strategy and gut microbes/metabolites may answer some of the crucial questions. This review briefly emphasizes the common functional attributes of glycation and gut microbes, the possible linkages, and discusses current treatment options and therapeutic challenges.

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Fructosamine and glycated hemoglobin as biomarkers of glycemic control in people with type 2 diabetes mellitus and cancer (GlicoOnco study)

Cited by 2 publications

References 30 publications

Early detection of type 2 diabetes risk: limitations of current diagnostic criteria

Early detection of type 2 diabetes risk: limitations of current diagnostic criteria

Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis

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