Fructooligosaccharides Ameliorate Renal Injury and Dysfunction Through the Modulation of Gut Dysbiosis, Inhibition of Renal Inflammation, Oxidative Stress, Fibrosis, and Improve Organic Anion Transporter 3 Function in an Obese Rat Model
Nattavadee Pengrattanachot,
Laongdao Thongnak,
Sasivimon Promsan
et al.
Abstract:ScopeHigh‐fat diet (HFD) consumption causes obesity and gut dysbiosis which induces kidney injury. It has been reported that prebiotics improve gut dysbiosis and insulin sensitivity and decelerate the progression of kidney disease. This study investigates the impact of fructooligosaccharides (FOS) on renoprotection and the prevention of gut dysbiosis and intestinal barrier injury in obese rats.Methods and resultsWistar rats are treated with HFD for 16 weeks. Then, the HFD fed rats (HF) are given FOS 1 g day−1 … Show more
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