Fructooligosaccharide Intake Alters the Phospholipid and Fatty Acid Composition of Liver Plasma Membranes

Petkova, Diana; Staneva, Galya; Markovska, Tania; Iliev, Ilia; Иванова, И.; Pankov, Roumen; Chakarov, Stoyan; Momchilova, Albena

doi:10.5504/bbeq.2011.0137

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…The obtained results showed that the content of cholesterol, expressed as mol%, was slightly reduced in membranes from inulin-fed rats. This finding is in accordance with our previous data obtained with rats on fructooligosaccharide (FOS)-enriched diet, which revealed a more marked decrease of cholesterol in liver plasma membranes [ 11 ]. In these investigations, we also established a lower degree of cholesterol oxidation, as well as a lower level of lipid peroxides in FOS-fed rats.…”

supporting

confidence: 93%

Effect of Inulin Intake on the Content and Susceptibility to Oxidative Damage of Cholesterol in Rat Liver Plasma Membranes

Petkova¹,

Markovska²,

Staneva³

et al. 2013

Proceeding BAS

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The influence of the prebiotic inulin on the level and sensitivity to oxidative attack has been investigated in rat liver plasma membranes. The obtained results showed that the oral administration of inulin in experimental animals induced a slight decrease of the content of cholesterol in liver plasma membranes. In addition, the susceptibility of cholesterol to oxidation, which was tested with cholesterol oxidase assay, was lower in membranes isolated from inulin-fed rats. Studies were also performed on the changes in the asymmetric distribution of cholesterol between the two leaflets of the membrane bilayer in order to elucidate the reasons for the observed differences in cholesterol sensitivity to oxidation. Basically, the alterations in the oxidation of cholesterol molecules could be due either to differences in the localization of cholesterol in the external membrane monolayer and/or to changes in the structural organization of the membranes. Our studies revealed a slight reduction of the cholesterol molecules in the outer membrane monolayer, which could be one possible reason for the observed reduction of cholesterol susceptibility to oxidative damage.

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supporting

confidence: 93%

Effect of Inulin Intake on the Content and Susceptibility to Oxidative Damage of Cholesterol in Rat Liver Plasma Membranes

Petkova¹,

Markovska²,

Staneva³

et al. 2013

Proceeding BAS

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“…However, quite a few studies are devoted to the impact of prebiotics on liver membrane lipids, their metabolism, and susceptibility to peroxidation. In our previous studies, we reported alterations in liver membrane lipid composition and structural organization as a result of the intake of fructooligosaccharides [ 24 ]. In the present study, we analyzed the impact of XOS intake on the lipid composition and susceptibility to the oxidative attack of cholesterol, the latter being altered in the liver plasma membranes of XOS-fed rats.…”

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confidence: 99%

Metabolic Profiling of Xylooligosaccharides by Lactobacilli

et al. 2020

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Three lactic acid bacteria (LAB) strains identified as Lactobacillus plantarum, Lactobacillus brevis, and Lactobacillus sakei isolated from meat products were tested for their ability to utilize and grow on xylooligosaccharides (XOSs). The extent of carbohydrate utilization by the studied strains was analyzed by HPLC. All three strains showed preferences for the degree of polymerization (DP). The added oligosaccharides induced the LAB to form end-products of typical mixed-acid fermentation. The utilization of XOSs by the microorganisms requires the action of three important enzymes: β-xylosidase (EC 3.2.1.37) exo-oligoxylanase (EC 3.2.1.156) and α-L-arabinofuranosidase (EC 3.2.1.55). The presence of intracellular β-D-xylosidase in Lb. brevis, Lb. plantarum, and Lb. sakei suggest that XOSs might be the first imported into the cell by oligosaccharide transporters, followed by their degradation to xylose. The studies on the influence of XOS intake on the lipids of rat liver plasma membranes showed that oligosaccharides display various beneficial effects for the host organism, which are probably specific for each type of prebiotic used. The utilization of different types of oligosaccharides may help to explain the ability of Lactobacillus strains to compete with other bacteria in the ecosystem of the human gastrointestinal tract.

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Intake of Xylooligosaccharides Alters the Structural Organization of Liver Plasma Membrane Bilayer

Staneva¹,

Petkova²,

Hazarosova³

et al. 2013

Food Biophysics

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Fructooligosaccharide Intake Alters the Phospholipid and Fatty Acid Composition of Liver Plasma Membranes

Abstract: ABSTRACT

Cited by 3 publications

References 40 publications

Effect of Inulin Intake on the Content and Susceptibility to Oxidative Damage of Cholesterol in Rat Liver Plasma Membranes

Effect of Inulin Intake on the Content and Susceptibility to Oxidative Damage of Cholesterol in Rat Liver Plasma Membranes

Metabolic Profiling of Xylooligosaccharides by Lactobacilli

Intake of Xylooligosaccharides Alters the Structural Organization of Liver Plasma Membrane Bilayer

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