Fructo-oligosaccharides reduce energy intake but do not affect adiposity in rats fed a low-fat diet but increase energy intake and reduce fat mass in rats fed a high-fat diet

Hadri, Zouheyr; Rasoamanana, Rojo; Fromentin, Gilles; Azzout‐Marniche, Dalila; Even, Patrick C.; Gaudichon, Claire; Darcel, Nicolas; Bouras, Abdelkader Dilmi; Tomé, Daniel; Chaumontet, Catherine

doi:10.1016/j.physbeh.2017.10.009

Cited by 6 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, it remains unclear if the higher body mass gain of HP + I-fed mice is a result of an increase in body fat or muscle mass. Unfortunately, we did not measure body composition in our study, but recently, it has been reported that rats fed with a 55 % high-protein diet with and without 10 % FOS for 5 weeks did not differ in body composition, even compared to the control group ( 45 ) .…”

Section: Discussionmentioning

confidence: 92%

“…Our finding is in line with previous experiments in BALB/c mice in which no effects on body weight were observed when a control diet was supplemented with 10 % of different fermentable dietary fibres, such as inulin, FOS, XOS, galacto-oligosaccharide (GOS), apple pectin, polydextrose or beta-glucan for 3 weeks of feeding ( 44 ) . Likewise in rats, feeding a 55 % HP diet containing 10 % FOS for 5 weeks had no effect on body weight and fat mass compared to controls albeit the energy intake was 10 % lower in the HP diet with FOS than in the control diet ( 45 ) . In contrast, rats fed with a high-fat diet (40 %) containing 10 % inulin for 3 weeks decreased cumulative food intake but not body weight and fat mass ( 46 ) .…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

A high-protein diet containing inulin/oligofructose supports body weight gain associated with lower energy expenditure and carbohydrate oxidation, and alters faecal microbiota in C57BL/6 mice

et al. 2021

View full text Add to dashboard Cite

Prebiotic supplements and high-protein (HP) diets reduce body weight and modulate intestinal microbiota. Our aim was to elucidate the combined effect of an inulin/oligofructose (FOS) and HP diet on body weight gain, energy metabolism and faecal microbiota. Forty male C57BL/6NCrl mice were fed a control (C) diet for 2 weeks and allocated to a C or HP (40 % protein) diet including no or 10 % inulin/FOS (C + I and HP + I) for 4 weeks. Inulin/FOS was added in place of starch and cellulose. Body weight, food intake, faecal energy and nitrogen were determined. Indirect calorimetry and faecal microbiota analysis were performed after 3 weeks on diets. Body weight gain of HP-fed mice was 36 % lower than HP + I- and C-fed mice (P < 0⋅05). Diet digestibility and food conversion efficiency were higher in HP + I- than HP-fed mice (P < 0⋅01), while food intake was comparable between groups. Total energy expenditure (heat production) was 25 % lower in HP + I- than in C-, HP- and C + I-fed mice (P < 0⋅001). Carbohydrate oxidation tended to be 24 % higher in HP- than in HP + I-fed mice (P < 0⋅05). Faecal nitrogen excretion was 31–45 % lower in C-, C + I- and HP + I- than in HP-fed mice (P < 0⋅05). Faecal Bacteroides–Prevotella DNA was 2⋅3-fold higher in C + I- and HP + I- relative to C-fed mice (P < 0⋅05), but Clostridium leptum DNA abundances was 79 % lower in HP + I- than in HP-fed mice (P < 0⋅05). We suggest that the higher conversion efficiency of dietary energy of HP + I but not C + I-fed mice is caused by higher digestibility and lower heat production, resulting in increased body mass.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 98%

A high-protein diet containing inulin/oligofructose supports body weight gain associated with lower energy expenditure and carbohydrate oxidation, and alters faecal microbiota in C57BL/6 mice

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 95%

“…Supplementation with individual FODMAP items as prebiotics have been shown to alter body composition, gut hormones, and gut microbiota in animal studies. Fructo-oligosaccharides added to a high fat diet reduced body fat mass and adiposity in rats(17). Galactooligosaccharides (GOS) supplementation lowered LDL-cholesterol, increased Bifidobacterium and reduced Clostridium in mice fed with high fat diet(18).…”

Section: Introductionmentioning

confidence: 99%

Higher habitual FODMAP intake is associated with lower body mass index, lower insulin resistance and higher short-chain fatty acid-producing microbiota in people with prediabetes

Chu

Ling

et al. 2022

Preprint

View full text Add to dashboard Cite

Aims/hypothesis: The quantity and quality of FODMAPs can alter the relative abundance of gut microbiota with metabolic consequences although similar data are lacking in people with prediabetes. We investigated associations between habitual FODMAP contents, gut microbiota and glucose/insulin responses in subjects with prediabetes. Methods: In this prospective cross-sectional study, ninety- eight subjects with impaired glucose tolerance (IGT) (mean age: 57+/-7 years, 43 % men) had assessment of body composition, 6-point oral glucose tolerance tests (OGTT), Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and 3-day dietary intake. We analysed faecal samples in a sub-group of 20 subjects with IGT and 10 subjects with normal glucose tolerance by 16S rRNA microbiome analysis. Results: Obese subjects with IGT had the lowest daily FODMAP intake compared with their non-overweight and non-obese counterparts (5.7 (3.9-7.9) vs 7.1 (5.0-11.3) vs 9.9 (4.1-22.4) g/day, p=0.024) despite having similar total daily energy intake. Total content of FODMAPs was negatively correlated with body fat. After adjustment for age and gender, total FODMAPs were negatively associated with BMI and HOMA-IR. This remained significant after adjustment for macronutrients and physical activity (p=0.032 and p=0.036 respectively). FODMAP contents were strongly associated with short-chain fatty acid (SCFA)-producing bacteria, such as Lactobacillus (p=0.011), Akkermansia muciniphila (p=0.012), and Bifidobacterium longum (p=0.010), the abundance of which were negatively correlated with 2-hr plasma glucose (r = -0.524, p =0.003). Conclusion: In individuals with IGT, higher habitual FODMAP intake was associated with lower body fat and insulin resistance and increased abundance of SCFA-producing bacteria, calling for interventional studies to evaluate the effects of FODMAP intake in prediabetes.

show abstract

“…The balance of deconjugated secondary bile acids [ 13 ], short-chain fatty acid (SCFA) [ 14 ], lipopolysaccharide (LPS) [ 8 ], and incretin secretion [ 15 – 17 ] are altered through the generation of active metabolites by these microbiotas during fermentation of FODMAP carbohydrates, which can change the metabolism of glucose and lipid. In one animal study, supplementation with FODMAP-rich diets as prebiotics altered body composition and gut microbiota [ 18 ]. The study also has shown that a high-fat diet rich in fructooligosaccharides (FOS) decreases mass and adiposity in rats [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the association between habitual dietary FODMAP intake, metabolic parameters, glycemic status, and anthropometric features among apparently healthy overweight and obese individuals

Hemami,

Shakarami,

Ardekani

et al. 2023

BMC Endocr Disord

View full text Add to dashboard Cite

Background The predisposition of humans to metabolic syndrome is affected by many factors, including diet and lifestyle. Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) are a set of carbohydrates that are fermented by gut microbiota. In animal studies, supplementation with FODMAP-rich diets as prebiotics can alter body composition and gut microbiota. This study evaluates any relationship between FODMAP and metabolic syndrome risk factors among adults with metabolic syndrome in Iran. Methods This cross-sectional study is based on sociodemographic information from 347 overweight and obese participants selected from outpatient clinics through public declaration. Participants body composition and anthropometric measures were also determined. A validated Food Frequency Questionnaire (FFQ) with 168 questions was used to collect dietary data. Biochemical parameters, including serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), fasting serum glucose (FSG), and insulin levels, were determined by enzymatic methods. In addition, the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) were calculated. Results In moderate FODMAP and low FODMAP groups, lower waist-to-hip ratio (WHR) and higher fat-free mass (FFM) were achieved in higher tertiles. In high FODMAP groups, higher systolic blood pressure (SBP) was shown in the higher tertile (P < 0.05). Higher insulin, HOMA-IR, and lower QUICKI in the second tertile of the high FODMAP group were also observed. Conclusion Findings of this study highlight the potential role of FODMAP in managing metabolic syndrome and open a new field of research.

show abstract

Fructo-oligosaccharides reduce energy intake but do not affect adiposity in rats fed a low-fat diet but increase energy intake and reduce fat mass in rats fed a high-fat diet

Cited by 6 publications

References 22 publications

A high-protein diet containing inulin/oligofructose supports body weight gain associated with lower energy expenditure and carbohydrate oxidation, and alters faecal microbiota in C57BL/6 mice

A high-protein diet containing inulin/oligofructose supports body weight gain associated with lower energy expenditure and carbohydrate oxidation, and alters faecal microbiota in C57BL/6 mice

Higher habitual FODMAP intake is associated with lower body mass index, lower insulin resistance and higher short-chain fatty acid-producing microbiota in people with prediabetes

Investigation of the association between habitual dietary FODMAP intake, metabolic parameters, glycemic status, and anthropometric features among apparently healthy overweight and obese individuals

Contact Info

Product

Resources

About