Fructo-oligosaccharide improved brain β-amyloid, β-secretase, cognitive function, and plasma antioxidant levels in D-galactose-treated Balb/cJ mice

Yen, Chi-Hua; Wang, Cheng-Hsin; Wu, Wen‐Tzu; Chen, Hsiao‐Ling

doi:10.1080/1028415x.2015.1110952

Cited by 29 publications

(15 citation statements)

References 45 publications

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“…Provided this limitation and the inability to make a direct comparison between OS controlled for dose, the data suggest that OS are capable of affecting and improving behavior yet had less clear of an impact on MRI and gene expression measures. While several studies have examined the effect of single oligosaccharide supplementation on cognition and brain development (Schmidt et al, 2015;Vázquez et al, 2015Vázquez et al, , 2016Jia et al, 2016;Savignac et al, 2016;Yen et al, 2017), here we explored the individual and combined effects of BMOS and HMO. The concentrations and diversity of OS in human milk vary to a great extent (McGuire et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Human and Bovine Milk Oligosaccharides Elicit Improved Recognition Memory Concurrent With Alterations in Regional Brain Volumes and Hippocampal mRNA Expression

et al. 2020

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Human milk contains a unique profile of oligosaccharides (OS) and preliminary evidence suggests they impact brain development. The objective of this study was to assess the impact of bovine and/or human milk oligosaccharides (HMO) (2-fucosyllactose and Lacto-N-neotetraose) on cognition, brain development, and hippocampal gene expression. Beginning on postnatal day (PND) 2, male pigs received one of four milk replacers containing bovine milk oligosaccharides (BMOS), HMO, both (BMOS + HMO), or neither. Pigs were tested on the novel object recognition task using delays of 1-or 48-h at PND 22. At PND 32-33, magnetic resonance imaging procedures were used to assess structural brain development and hippocampal tissue was collected for analysis of mRNA expression. Pigs consuming only HMO exhibited recognition memory after a 1-h delay and those consuming BMOS + HMO exhibited recognition memory after a 48-h delay. Both absolute and relative volumes of cortical and subcortical brain regions were altered by diet. Hippocampal mRNA expression of GABRB2, SLC1A7, CHRM3, and GLRA4 were most strongly affected by diet. HMO and BMOS had distinct effects on brain structure and cognitive performance. These data suggest different mechanisms underlie their influence on brain development.

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Section: Discussionmentioning

confidence: 99%

Human and Bovine Milk Oligosaccharides Elicit Improved Recognition Memory Concurrent With Alterations in Regional Brain Volumes and Hippocampal mRNA Expression

et al. 2020

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“…These result indicated that polyphenols, flavonoids, and non-polar components reported as functional components in tomatoes showed low possibilities of being active components in the functionality of TEE. Therefore, we suggest that the enhancing effect of TEE on cognitive function via BDNF production might be derived from poly/oligo-saccharides because TEE (50% ethanolic extract of tomato) contained various hydrophilic saccharides [43,44]. …”

Section: Discussionmentioning

confidence: 99%

Lycopersicon esculentum Extract Enhances Cognitive Function and Hippocampal Neurogenesis in Aged Mice

et al. 2016

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A decrease in adult neurogenesis is associated with the aging process, and this decrease is closely related to memory impairment. Tomato (Lycopersicon esculentum) is a fruit with diverse bioactive nutrients that is consumed worldwide. In this study, we investigated the cognition-enhancing effect of tomato ethanolic extracts (TEE) in aged mice. Six weeks of oral TEE administration in 12-month-old aged mice significantly increased their exploration time of novel objects when compared to vehicle-treated mice. The TEE supplement increased doublecortin (DCX)-positive cells and postsynaptic density-95 (PSD95) expression in mice hippocampus. Moreover, we found an increased expression of brain-derived neurotrophic factor (BDNF) and subsequently-activated extracellular-signal-regulated kinase (ERK)/cAMP response element binding (CREB) signaling pathway in the TEE-supplemented mice hippocampus. In conclusion, the oral administration of TEE exhibits a cognition-enhancing effect, and the putative underlying mechanism is the induction of BDNF signaling-mediated proliferation and synapse formation in the hippocampus. These findings indicate that TEE could be a candidate for treatment of age-related memory impairment and neurodegenerative disorders.

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“…Enhanced brain Aβ and amyloid precursor protein (APP) aggregation is closely associated with the development of AD (2). Extracellular amyloid plaques identified in AD, including Aβ 1-40 and Aβ , are derived from the larger APP by β-secretase and γ-secretase (3). An inhibitor of γ-secretase, semagacestat, has been reported to cause neurotoxicity, thus its clinical application is limited; therefore, a safe and effective suppressor of β-secretase may be considered a promising treatment approach (4,5).…”

Section: Introductionmentioning

confidence: 99%

Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mTOR signaling‑dependent mechanism

Huang

Zhong

et al. 2019

Mol Med Report

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Okadaic acid (OA)-induced neurotoxicity may be considered a novel tool used to study Alzheimer's disease (AD) pathology, and may be helpful in the development of a novel therapeutic approach. It has been reported that galangin inhibits β-site amyloid precursor protein-cleaving enzyme 1 expression, which is a key enzyme for amyloid β (Aβ) generation and is a potential drug candidate for AD therapy. However, further studies are required to confirm its neuroprotective effects in other AD models. The present study aimed to explore the neuroprotective effects of galangin on OA-induced neurotoxicity in PC12 cells. The cells were divided into the following groups: Control group, model group (175 nM OA for 48 h) and galangin groups (0.25, 0.5 and 1 µg/ml). Beclin-1, phosphorylated (p)-protein kinase B (Akt), p-glycogen synthase kinase (GSK)3β and p-mechanistic target of rapamycin (mTOR) expression was also measured in the following PC12 cell groups: Control group, model group, 3-methyladenine group (5 nM), rapamycin group (100 nM) and galangin group (1 µg/ml). The levels of β-secretase, Aβ 42 and p-tau were detected by ELISA, Beclin-1 expression was examined by immunohistochemistry and the protein expression levels of p-Akt, p-mTOR p-GSK3β, and Beclin-1 were detected by western blotting. Galangin treatment enhanced cell viability in cells treated with OA, and decreased β-secretase, Aβ 42 and p-tau levels. In addition, it suppressed Beclin-1 and p-GSK3β expression, but promoted p-Akt and p-mTOR expression by regulating the Akt/GSK3β/mTOR pathway. These results indicated that galangin protected PC12 cells from OA-induced cytotoxicity and inhibited autophagy via the Akt/GSK3β/mTOR pathway, thus suggesting that it may be considered a potential therapeutic agent for AD.

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Fructo-oligosaccharide improved brain β-amyloid, β-secretase, cognitive function, and plasma antioxidant levels in D-galactose-treated Balb/cJ mice

Abstract: Dietary FO (2.5-5% w/w diet) could attenuate the development of Alzheimer's disease, which was likely to be associated with its systematic antioxidant effects.

Cited by 29 publications

References 45 publications

Human and Bovine Milk Oligosaccharides Elicit Improved Recognition Memory Concurrent With Alterations in Regional Brain Volumes and Hippocampal mRNA Expression

Human and Bovine Milk Oligosaccharides Elicit Improved Recognition Memory Concurrent With Alterations in Regional Brain Volumes and Hippocampal mRNA Expression

Lycopersicon esculentum Extract Enhances Cognitive Function and Hippocampal Neurogenesis in Aged Mice

Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mTOR signaling‑dependent mechanism

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