Frozen faecal matter works as well as fresh for transplantation in<i>C difficile</i>patients

Wise, Jacqui

doi:10.1136/bmj.i138

Cited by 6 publications

(2 citation statements)

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“…For the route of FMT, in our included studies, all the transplantations are through fresh or frozen feces. In general, frozen feces have advantages over fresh in aspects of preparation, storage, monitoring, and delivering FMT at centers that do not have on-site laboratory facilities [31, 32]. Without direct evidence on UC, multistudies of Clostridium difficile infection patients demonstrated that compared to fresh FMT, frozen FMT had equal effects and risk of adverse events [32–36].…”

Section: Discussionmentioning

confidence: 99%

The Clinical and Steroid-Free Remission of Fecal Microbiota Transplantation to Patients with Ulcerative Colitis: A Meta-Analysis

Lam

Zhao

Wen

et al. 2019

Gastroenterology Research and Practice

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Background and Purpose. Since the first case of fecal microbiota transplantation for the treatment of ulcerative colitis was described in the year 1989, there have been an increment of case reports, case series, cohort studies, and randomized controlled trials (RCTs). In this study, we were going to investigate general clinical remission, clinical response, and steroid-free remission of fecal microbiota transplantation. Methods. We searched Ovid Medline, Ovid EMBASE, and Cochrane Library, focusing prospective studies including randomized controlled trials and cohort studies. The outcomes were clinical remission, clinical response, steroid-free remission, and serious adverse events. We used RevMan 5.3 software for meta-analyses. Key Results. A total of 4 RCTs and 2 cohort studies (340 cases from 5 countries) were included. We found that FMT might be more effective than placebo on clinical remission (OR, 3.85 [2.21, 6.7]; P<0.001; I2=0%) and clinical response (OR, 2.75 [1.33, 5.67]; P=0.006; I2=49%), but no statistical difference on steroid-free remission (OR, 2.08 [0.41, 10.5]; P=0.37; I2=69%) and serious adverse events (OR, 2.0 [0.17, 22.97]; P=0.44; I2=0%). Conclusions and Inferences. Fecal microbiota transplantations were associated with significant clinical remission and response in ulcerative colitis patients while there was no significant difference found between FMT and placebo in steroid-free remission. Moreover, a common consensus on the route, volume, timing, preferred donor characteristics, and frequency of fecal administration is necessary to achieve remission.

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Section: Discussionmentioning

confidence: 99%

The Clinical and Steroid-Free Remission of Fecal Microbiota Transplantation to Patients with Ulcerative Colitis: A Meta-Analysis

Lam

Zhao

Wen

et al. 2019

Gastroenterology Research and Practice

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“…After collection, HIF was successively filtered through screen cloths of 2.0, 1.0, and 0.5 mm. Then, 10% glycerin was added to the filtrate as a cryoprotectant and HIF was turned into the lyophilized powder by lyophilizer ( 19 , 21 ), keeping the water content below 5% and mucus content below 10%. Finally, the lyophilized powder was packaged in an enteric capsule shell of an acid-resistant acrylic resin, which would only disintegrate in small intestine.…”

Section: Preparation Methods Of Hift Capsulesmentioning

confidence: 99%

Fecal Microbiota and Human Intestinal Fluid Transplantation: Methodologies and Outlook

Chen

Zhao²,

Cui³

et al. 2022

Front. Med.

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Fecal microbiota transplantation (FMT) is a therapy that involves the transplantation of healthy human fecal microorganisms into the gut of patients to rebuild or consolidate the intestinal microecology. It has been utilized in many diseases. However, FMT had a limited effect on patients with small intestinal diseases because of the unique ecological characteristics of the microorganisms. Thus, we proposed a new microecology transplantation therapy called human intestinal fluid transplantation (HIFT). Human intestinal fluid can be collected through a nasojejunal tube and be made into capsules using the freeze-dried powder method. In addition, strict standards for donor screening and management have been established. We are currently developing a high-standard HIFT preparation system and conducting high-quality clinical studies to validate the safety and efficacy of HIFT combined with FMT.

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Fecal microbiota transplantation: Review and update

Wang

Kuo

et al. 2019

Journal of the Formosan Medical Association

301

239

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Fecal microbiota transplantation (FMT) is a method to directly change the recipient's gut microbiota to normalize the composition and gain a therapeutic benefit. The history of FMT has been traced back to the 4th century and has been highly regarded since 2013, when the United States Food and Drug Administration approved FMT for treating recurrent and refractory Clostridium difficile infection. Since then, the range of FMT applications extended rapidly and broadly not only in gastrointestinal disorders, but also in extra-gastrointestinal diseases. Donor selection with questionnaire, interview, blood tests, and stool examinations should be strictly performed before FMT to reduce and prevent occurrence of any adverse events. Step-by-step cautious fecal and recipient preparation along with adequately choosing delivery methods based on individual clinical situations are key points of the FMT process. Although current evidence deems FMT as a generally safe therapeutic method with few adverse effects, the long-term outcomes of FMT have not been completely elucidated. Therefore, establishing periodicity and length of regular follow-up after FMT to monitor the clinical efficacy and long-term adverse events are other essential issues. In the future, we will look forward to personalized FMT for different patients and conditions according to varied hosts and diseases.

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Frozen faecal matter works as well as fresh for transplantation inC difficilepatients

Cited by 6 publications

References 0 publications

The Clinical and Steroid-Free Remission of Fecal Microbiota Transplantation to Patients with Ulcerative Colitis: A Meta-Analysis

The Clinical and Steroid-Free Remission of Fecal Microbiota Transplantation to Patients with Ulcerative Colitis: A Meta-Analysis

Fecal Microbiota and Human Intestinal Fluid Transplantation: Methodologies and Outlook

Fecal microbiota transplantation: Review and update

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