Frontotemporal dementia is a complex disorder with a wide spectrum of clinical symptoms. Personalized medicine and gene therapy are promising strategies for treatment

2021

Preprint

Global Initiative for Chronic Obstructive Lung Disease (GOLD) research on chronic obstructive pulmonary condition (COPD) characterizes it as a prevalent, preventable, and curable illness with persistent respiratory symptoms and airflow limitation. airway blockage resulting in dyspnoea and air trapping when exercising airflow restriction can be attributed to smoking, ambient tobacco smoke exposure, and the patient's TB history COPD airflow restriction is largely caused by airway tightness, chronic bronchitis, or emphysema. Repeated inhalation of hazardous particles induces chronic inflammatory immune cell infiltration, tissue repair, and airway remodeling, resulting in a 4-to 40-fold increase in airway resistance and bronchiolar constriction. 20% of small airways are bronchi, with the rest being either bronchioles or alveolar ductal gaps. Flow restriction includes alveolar wall disintegration and alveolar support. The modifications worsen the rapid FEV1 fall and contribute to the airway obstruction seen in COPD. COPD, small airway disease (SAD), has been extensively studied. Inflammation, fibrosis, and destruction of bronchioles are all indications of this illness. mixed pulmonary fibrosis and emphysema (CPFE). In fact, fibrosis appears to be involved in the obstruction of small airways.RAGE participates in several intracellular processes by binding to several ligands. RAGE ligand interactions trigger downstream signaling pathways that have been associated with COPD and other disorders. Thus, inhibitors of RAGE and its signaling pathways also have been found to play a function in other disorders, which suggests that they might be used to treat COPD. There are currently no established biomarkers to diagnose COPD. COPD patients are shown to have altered RAGE and some of its ligands. Despite a lack of agreement on how smoking affects sRAGE levels, greater study is needed to discover whether or not this biomarker is stable. It was discovered that among the North Han Chinese,-429T > C is associated with COPD. COPD vulnerability is furthermore associated with the genetics of RAGE. To get a better diagnosis, population-based studies are needed. Finally, RAGE, AGE-RAGE, and sRAGE all impact COPD, and RAGE may be employed as a biomarker for diagnosis and management of COPD patients if more study supports this hypothesis.

Section: In Copd the Age-rage Axis And Srage Play A Rolementioning

confidence: 99%

Chronic obstructive pulmonary condition (COPD) is a prevalent, preventable, and curable illness with persistent respiratory symptoms and airflow limitation

2021

Preprint

“…A large, cohort research comprising 132 participants with CKD discovered that urine ET-1 levels increased in individuals with SLE, even when their GFR was normal (72). Giant mesangial cell proliferation and matrix generation is associated with the presence of ET-1 in SLE patients (73,74). Renal ET-1 and ETB receptors are present in NZB/WF1 mice (34).…”

Section: Glomerulonephritis Renal Lupusmentioning

confidence: 99%

The vasoconstrictor endothelin system involvement in chronic kidney diseases pathogenesis is now the most often employed treatment method

2021

Preprint

Over 30,000 publications have been published about the vasoconstrictor endothelin-1, which was identified by Yanagisawa and co-workers in 1988. While the evidence is quite compelling, scientists can only speculate on how the endothelin (ET) system affects blood pressure and renal function at this time. ET system involvement in chronic kidney diseases (CKD) pathogenesis is now the most often employed treatment method. ET1, ET2, and ET3 are all members of the endothelin family. Endothelium, renal, and smooth muscle cells all generate ET-1, a significant isoform found in both cardiovascular and renal systems.Kidney cells act on, and contain, ET-1. The ETA receptor is found in the brain and medulla, but not in the vasa recta or glomeruli. Epithelial and endothelial cells contain the ETB receptor, which is most prominent in collecting duct cells. 3 In several experiments, ET-1 has been established to be largely a preglomerular vasoconstrictor. Mesangial proliferation, contraction, and collagen production are regulated by ET-1 and ETB receptors in podocytes. The epithelium in the collecting duct cells in the medulla is important in controlling Na excretion and BP. Without the ET-1 gene, the mice have hypertension and reduced natriuresis in response to salt loading. Et-1, ETB receptor, and hypertension are shown in mice that have lost the ETB receptor gene. There is no correlation between blood pressure regulation and natriuresis.Combined disruption of the ETA and ETB receptors has greater effects on blood pressure and Na reabsorption than when ETB receptor activity is missing. It appears that the ETB receptor doesn't work until ETB is present. Collecting duct-derived ET receptors reduces the transport of sodium. Src kinase and MAPK1/2 decrease epidermal Na channel (ENaC) function, decreasing water and salt reabsorption. Moreover, inner medullary collecting duct cells and vasa recta-bearing cells will release NO, which decreases sodium transport.

“…Transfection of the IL-6 gene inhibited tumor development in a mouse fibrosarcoma model (79). Furthermore, therapeutic immunization with autologous tumor cells expressing IL-6 and IL-2 prevents tumor growth in a lung metastasis model and results in total melanoma regression in a well-established metastatic mouse melanoma model (80).…”

Section: In Cancer Immunotherapy Cytokines Play An Important Rolementioning

confidence: 99%

Mesenchymal stem cells strategies in cancer immunotherapy

2021

Preprint

Mesenchymal stem cells (MSCs) have been a new research focus for cancer treatment. Future cancer sufferers will considerably profit from their use in the future. Tumor-directed migratory and integration capacities of MSCs are exceptional, making them potential carriers for the delivery of anticancer medicines, notably cytokines. Their usage in the clinic has lasted around 10 years. The use of mesenchymal stem cells (MSCs) to create successful cancer treatments has been demonstrated in everything from animal models to human studies.