Frontotemporal atrophy associated with paranoid delusions in women with Alzheimer's disease

Whitehead, Daisy L.; Tunnard, Catherine; Hurt, Catherine S.; Wahlund, Lars‐Olof; Mecocci, Patrizia; Tsolaki, Magda; Vellas, Bruno; Spenger, Christian; Kłoszewska, Iwona; Soininen, Hilkka; Cromb, Daniel; Lovestone, Simon; Simmons, Andrew

doi:10.1017/s1041610211000974

Cited by 38 publications

(36 citation statements)

References 31 publications

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“…A magnetic resonance imaging study in AD+P demonstrated reduced frontotemporal cortical thickness in women, but not men, with AD+P. (Whitehead et al, 2012) A voxel-based analysis of whole brain cerebral perfusion was undertaken in a large sample of AD+P (N=51) and AD−P (N=52) subjects. (Moran et al, 2008) In this study, perfusion patterns were vastly different between AD+P females and AD+P males.…”

Section: Discussionmentioning

confidence: 99%

Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities

Koppel

Acker

Davies

et al. 2014

Neurobiology of Aging

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Section: Discussionmentioning

confidence: 99%

Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities

Koppel

Acker

Davies

et al. 2014

Neurobiology of Aging

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“…Reductions in frontal cortex gray matter were most consistently reported across studies, although parietal cortex was also affected. One study also reported sex differences in AD + P with only female subjects showing reduced cortical thickness in left orbitofrontal, superior temporal, and insular regions (64). Magnetic resonance imaging has also been used to evaluate whether white matter hyperintensities associate with AD + P, with inconsistent results (Table S3 in Supplement 1).…”

Section: Neuroimaging Studies Of Psychosis In Alzheimer’s Diseasementioning

confidence: 99%

“…A number of magnetic resonance imaging studies of gray matter volume have been reported in AD + P, using both region of interest and voxel-based comparisons (61–64). Studies were consistent in demonstrating an association of AD + P with decreased gray matter volumes (Figure 3).…”

Section: Neuroimaging Studies Of Psychosis In Alzheimer’s Diseasementioning

confidence: 99%

Psychosis in Alzheimer’s Disease

Murray

Kumar

DeMichele-Sweet

et al. 2014

Biological Psychiatry

164

160

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Psychotic symptoms, delusions and hallucinations, occur in approximately 50% of individuals with Alzheimer’s disease (AD) (AD with psychosis [AD + P]). Pharmacotherapies for AD + P have limited efficacy and can increase short-term mortality. These observations have motivated efforts to identify the underlying biology of AD + P. Psychosis in AD indicates a more severe phenotype, with more rapid cognitive decline beginning even before psychosis onset. Neuroimaging studies suggest that AD + P subjects demonstrate greater cortical synaptic impairments than AD subjects without psychosis, reflected in reduced gray matter volume, reduced regional blood flow, and reduced regional glucose metabolism. Neuroimaging and available postmortem evidence further indicate that the impairments in AD + P, relative to AD subjects without psychosis, are localized to neocortex rather than medial temporal lobe. Neuropathologic studies provide consistent evidence of accelerated accumulation of hyperphosphorylated microtubule associated protein tau in AD + P. Finally, studies of familial aggregation of AD + P have established that the risk for psychosis in AD is, in part, genetically mediated. Although no genes are established as associated with AD + P, the first genome-wide association study of AD + P has generated some promising leads. The study of the neurobiology of AD + P is rapidly accelerating and may be poised for translational discovery. This process can be enhanced by identifying points of convergence and divergence with the neurobiology of AD proper and of schizophrenia, by innovative extension of current approaches, and by development of relevant animal models.

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“…Patients with AD, particularly women showing paranoid delusions, had cortical atrophy in the left medial orbitofrontal, left superior temporal cortices, and the left insula, independent of cognitive decline 3 .…”

mentioning

confidence: 94%

Cortical correlates of affective syndrome in dementia due to Alzheimer’s disease

Hayata

Bergo

Rezende

et al. 2015

Arq. Neuro-Psiquiatr.

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Neuropsychiatric syndromes (NPS) in dementia due to Alzheimer' s disease (AD) have received growing attention across clinical centers and research settings in the last few decades. The high prevalence of NPS and their increasing severity in AD patients aggravate the disease' s course and cause distress for caregivers. These symptoms, once considered secondary behavior due to cognitive and functional impairment in dementia, have shown patterns of temporal course, which do not necessarily follow the linear decline of cognitive impairment.Several NPS seem to be more prevalent and clinically prominent in distinct stages of the disease. Depression is the most common syndrome in mild-to-moderate AD, while delusions, hallucinations, and aggression seem to be more common as the disease progresses, whereas apathy remains across all stages of AD, worsening as the global deterioration aggravates. However, these manifestations, also detected in mild cognitive impairment (MCI), increase the risk of dementia and may occur in prodromal AD.Moreover, aberrant vocalizations commonly emerge when patients are in advanced stages of dementia. Despite the fact that NPS and cognitive alterations may considerably overlap, these findings suggest distinct etiologies for both conditions. Furthermore, over the course of the disease, the prevalence of NPS reaches 50-90% of patients with dementia AbstrACtNeuropsychiatric symptoms in Alzheimer's disease (AD) are prevalent, however their relationship with patterns of cortical atrophy is not fully known. Objectives: To compare cortical atrophy's patterns between AD patients and healthy controls; to verify correlations between neuropsychiatric syndromes and cortical atrophy. Method: 33 AD patients were examined by Neuropsychiatric Inventory (NPI). Patients and 29 controls underwent a 3T MRI scanning. We considered four NPI syndromes: affective, apathy, hyperactivity and psychosis. Correlations between structural imaging and neuropsychiatric scores were performed by Freesurfer. Results were significant with a p-value < 0.05, corrected for multiple comparisons. Results: Patients exhibited atrophy in entorhinal cortices, left inferior and middle temporal gyri, and precuneus bilaterally. There was correlation between affective syndrome and cortical thickness in right frontal structures, insula and temporal pole. Conclusion: Cortical thickness measures revealed atrophy in mild AD. Depression and anxiety symptoms were associated with atrophy of right frontal, temporal and insular cortices.Keywords: depression, anxiety, MRI, neurodegenerative disease, neuropsychiatry. resumo Os sintomas neuropsiquiátricos na doença de Alzheimer (DA) são prevalentes, porém suas relações com padrões de atrofia cortical não são totalmente compreendidas. Objetivos: Comparar padrões de atrofia cortical entre DA e controles; verificar se há correlações entre sintomas neuropsiquiátricos e atrofia cortical. Método: 33 pacientes com DA foram examinados pelo Inventário Neuropsiquiátrico. Os pacientes e 29 controles foram submeti...

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Frontotemporal atrophy associated with paranoid delusions in women with Alzheimer's disease

Cited by 38 publications

References 31 publications

Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities

Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities

Psychosis in Alzheimer’s Disease

Cortical correlates of affective syndrome in dementia due to Alzheimer’s disease

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