Frontostriatal Measurement in Treatment-Naive Children With Obsessive-Compulsive Disorder

Rosenberg, David; Keshavan, Matcheri S.; O’Hearn, Kirsten; Dick, Elizabeth L.; Bagwell, W.W.; Seymour, Andrew B.; Montrose, Debra M.; Pierri, Joseph N.; Birmaher, Boris

doi:10.1001/archpsyc.1997.01830210068007

Cited by 225 publications

(133 citation statements)

References 49 publications

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“…For example, results from recent investigations suggest that there are morphometric distinctions between obsessive-compulsive disorder (OCD) and other anxiety disorders. Pediatric OCD is associated with smaller striatum structures (caudate and putamen) (Rosenberg et al 1997b) and a selective deficit in frontostriatal function (Rosenberg et al 1997a) in medication naive subjects. Striatal abnormalities are also seen in adult OCD (Modell et al 1989;Robinson et al 1995).…”

Section: Discussionmentioning

confidence: 99%

“…Intracranial volumes were calculated by first manually tracing the intracranial volume of each coronal slice after exclusion of the cranium, summing these areas of successive coronal slices, including gray and white matter and cerebral spinal fluid (CSF) volumes, and multiplying by slice thickness. Cerebral volumes were measured after exclusion of cerebellum and brainstem in the same manner and include cortical and subcortical structures (Rosenberg et al 1997b).…”

Section: Image Analysismentioning

confidence: 99%

“…This computerized segmentation technique uses mathematically derived cutoffs for gray matter-white matter-CSF partitions with histograms of signal intensities and includes cortical and subcortical white and gray matter volumes (Rosenberg et al 1997b).…”

Section: Cerebral White and Gray Matter Volumesmentioning

confidence: 99%

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A pilot study of amygdala volumes in pediatric generalized anxiety disorder

Bellis

Casey

Dahl

et al. 2000

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Section: Discussionmentioning

confidence: 99%

Section: Image Analysismentioning

confidence: 99%

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A pilot study of amygdala volumes in pediatric generalized anxiety disorder

Bellis

Casey

Dahl

et al. 2000

Biological Psychiatry

300

196

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“…On the University of Pittsburgh MR scanner a three dimensional SPGR acquisition in the steady state pulse sequence was utilized to obtain 1.5 mm coronal images (TE = 20 msec, TR = 40 msec, acquisition matrix = 256 x 192, FOV = 20 cm, flip angle = 10°). Image acquisition has been described in detail in our previous reports (Gilbert et al, 2000, MacMaster and Kusumakar, 2004a, MacMaster and Kusumakar, 2004b, MacMaster et al, 2006, Nolan et al, 2002, Rosenberg et al, 1997, Szeszko et al, 2004a, Szeszko et al, 2004b. All MRI scans were reviewed to rule out any clinically significant abnormalities.…”

Section: Image Acquisition and Analysismentioning

confidence: 99%

Development and sexual dimorphism of the pituitary gland

et al. 2007

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The pituitary gland plays a central role in sexual development and brain function. Therefore, we examined the effect of age and gender on pituitary volume in a large sample of healthy children and adults. Volumetric magnetic resonance imaging (MRI) was conducted in one hundred and fifty four (77 males and 77 females) healthy participants. Males were between the ages of 7 to 35 years (16.91 ± 5.89 years) and females were 7 to 35 years of age (16.75 ± 5.75 years). Subjects were divided into subgroups of age (7 to 9, 10 to 13, 14 to 17, 18 to 21, 22 and older) and sex (male/female). Pituitary gland volume differed between sexes when comparing the age groups (F = 3.55, df = 2, 143, p = 0.03). Females demonstrated larger pituitary glands than males in the age 14 to 17 year old groups (p = 0.04). Young (19 years and under) and old (20 years and older) females demonstrated a correlation between pituitary volume and age. Males did not show this relationship. These findings provide additional evidence for gender differences in the normative anatomy of the pituitary and may have relevance for the study of various childhood onset neuropsychiatric disorders in which pituitary dysfunction has been implicated.

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“…9 NMDA and AMPA/kainate glutamate receptors also appear to play a role in modulating the release and metabolism of serotonin in rat striatum, 10 a portion of the brain implicated in OCD. 11,12 Two lines of evidence support SLC1A1/EAAC1 as a candidate gene in OCD. SLC1A1 is a positional candidate on the basis of its proximity to the non-parametric linkage peak on chromosome 9.…”

Section: Introductionmentioning

confidence: 99%

Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder

et al. 2001

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The first genome scan conducted in early-onset obsessive-compulsive disorder used a nonparametric analysis to identify a peak in a region of chromosome 9 containing the gene SLC1A1, which codes for the neuronal and epithelial glutamate transporter EAAC1. Interaction between the glutamatergic and serotonergic systems within the striatum suggests EAAC1 as a functional candidate in OCD as well. We determined the genomic organization of SLC1A1 primarily by using primers designed from cDNA sequence to amplify from adaptor-ligated genomic DNA restriction fragments. In order to confirm SLC1A1 as a positional candidate in early-onset OCD, common single nucleotide polymorphisms (SNPs) were identified that enabled mapping of SLC1A1 within the region of the lod score peak. Based on the linkage evidence, the coding region was sequenced in the probands of the seven families included in the genome scan. No evidence was found for a functional mutation, but several SNPs were identified. Capillary electrophoresis SSCP typing of a haplotype consisting of two common SNPs within EAAC1 revealed no significant linkage disequilibrium. Molecular Psychiatry (2001) 6, 160-167.

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Frontostriatal Measurement in Treatment-Naive Children With Obsessive-Compulsive Disorder

Abstract: Our findings provide new evidence of abnormalities of the striatum in pediatric OCD. These results are preliminary, given the small sample size.

Cited by 225 publications

References 49 publications

A pilot study of amygdala volumes in pediatric generalized anxiety disorder

A pilot study of amygdala volumes in pediatric generalized anxiety disorder

Development and sexual dimorphism of the pituitary gland

Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder

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