Frontoparietal Network Connectivity During an N-Back Task in Adults With Autism Spectrum Disorder

Yuk, Veronica; Urbain, Charline; Anagnostou, Evdokia; Taylor, Margot J.

doi:10.3389/fpsyt.2020.551808

Cited by 11 publications

(23 citation statements)

References 206 publications

(301 reference statements)

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“…This can be associated with significant synchronization and temporal coherence dysfunction, decreasing large cortical networks between the two hemispheres from binding temporally and spatially. This can result in a functional disconnection syndrome ( 88 , 102 , 135 , 137 , 279 , 289 , 290 ).…”

Section: Discussionmentioning

confidence: 99%

Retained Primitive Reflexes and Potential for Intervention in Autistic Spectrum Disorders

et al. 2022

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We provide evidence to support the contention that many aspects of Autistic Spectrum Disorder (ASD) are related to interregional brain functional disconnectivity associated with maturational delays in the development of brain networks. We think a delay in brain maturation in some networks may result in an increase in cortical maturation and development in other networks, leading to a developmental asynchrony and an unevenness of functional skills and symptoms. The paper supports the close relationship between retained primitive reflexes and cognitive and motor function in general and in ASD in particular provided to indicate that the inhibition of RPRs can effect positive change in ASD.

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Section: Discussionmentioning

confidence: 99%

Retained Primitive Reflexes and Potential for Intervention in Autistic Spectrum Disorders

et al. 2022

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“…For estimation of task-related power the time-window of interest was 900-1900ms post-stimulus onset (i.e., during the fixation cross of the next trial). This time-window was chosen as existing studies investigating WM-related oscillatory activity typically use the maintenance period of the working memory task as the time-window of interest as increased oscillatory activity is observed during this period [20,24,31,46]. We followed the previous literature’s definition of the maintenance period as the time following a response to the stimuli, determined using the average (or median) response time on the given task [31].…”

Section: Methodsmentioning

confidence: 99%

“…Studies in neurodevelopmental disorders that experience overlapping cognitive impairments with NF1 (e.g., ADHD/ASD [14]) have reported differences in oscillatory activity during working memory performance relative to typically-developing controls [27,28,29,30,31]. For instance, Jang et al [28] found significantly reduced theta power in ADHD relative to controls.…”

Section: Introductionmentioning

confidence: 99%

“…Consistent with previous work [17], we hypothesised higher resting state spectral power in NF1, but normal power reactivity during eyes open versus eyes closed resting state conditions. Our analysis of oscillatory activity during working memory was largely exploratory; however, we predicted aberrant theta power and frontoparietal theta phase coherence given previous WM-related EEG studies in other neurodevelopmental disorders [29,31]. Finally, the association between EEG measures and age, overall cognitive function, and working memory performance were also explored.…”

Section: Introductionmentioning

confidence: 99%

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Aberrant oscillatory activity in Neurofibromatosis Type 1: An EEG study of resting state and working memory

Booth¹,

Garg

Brown

et al. 2022

Preprint

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Background: Neurofibromatosis Type 1 (NF1) is a genetic neurodevelopmental disorder commonly associated with impaired cognitive function. Despite the well-explored functional roles of neural oscillations in neurotypical populations, only a limited number of studies have investigated oscillatory activity in the NF1 population. Methods: We compared oscillatory spectral power and theta phase coherence in a paediatric sample with NF1 (N=16; mean age: 13.03 years; female: n=7) to an age/sex-matched typically-developing control group (N=16; mean age: 13.34 years; female: n=7) using electroencephalography measured during rest and during working memory task performance. Results: Relative to typically-developing children, the NF1 group displayed higher resting state slow wave power and a lower peak alpha frequency. Moreover, higher theta power and frontoparietal theta phase coherence were observed in the NF1 group during working memory task performance, but these differences disappeared when controlling for baseline (resting state) activity. Conclusions: Overall, results suggest that NF1 is characterised by aberrant resting state oscillatory activity that may contribute towards the cognitive impairments experienced in this population. Trial registration: ClinicalTrials.gov identifier: NCT03310996 (first posted: October 16 2017).

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“…Because of this effect on cognitive functioning, and the important role that cognitive functioning plays in helping individuals deal with anxiety-provoking stimuli (Bishop et al, 2004), it is not surprising that disruption in the FPN is also associated with anxiety that emerges from an inability to solve problems and think through challenges, resulting in GAD in particular (Ball et al, 2013;Cui et al, 2016;Etkin et al, 2009;Liao et al, 2013;Sylvester et al, 2012). There is also evidence of an association between disruption of the FPN and SF (Marek & Dosenback, 2018;Ptak, 2011;Scolari et al, 2015) in the non-autistic population, plus some evidence for an altered FPN in the autistic population (Lin et al, 2019;May & Kana, 2020;O'Reilly et al, 2017;Yuk et al, 2020). However, these findings have primarily focused on executive functioning deficits, rather than on SF and GAD specifically.…”

mentioning

confidence: 99%

Frontoparietal connectivity, Sensory Features, and Anxiety in Children and Adolescents with Autism Spectrum Disorder

Sarmukadam

Bitsika

Sharpley

2022

Adv Neurodev Disord

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Objectives Because atypical global neural connectivity has been documented in autistic youth, but only limited data are available regarding the association between generalized anxiety disorder (GAD), sensory features (SF), and neural connectivity between frontal and parietal brain regions, these links were investigated in a sample of male autistic children and adolescents. Methods Forty-one autistic males aged between 6 and 18 years and their mothers were recruited as volunteer participants from Queensland, Australia. Participants underwent 3 min of eyes-closed and 3 min of eyes-opened electroencephalography (EEG) under resting conditions. EEG connectivity was investigated using Granger causality between frontal and parietal regions in alpha (8–13 Hz) and beta (13–30 Hz) bands. Results There was a significant (p < .01) positive correlation between SF and GAD. GAD was associated with some characteristics of SF in the sample population. Additionally, there was a significant (p < .01) inverse correlation between directional frontoparietal connectivity and SF during the eyes-closed condition, specifically in relation to avoiding stimuli and sensitivity to the environment. Conclusions Reduced frontoparietal connectivity in association with higher anxiety and SF may demonstrate reduced relaxation due to greater sensitivity to sensory input.

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Frontoparietal Network Connectivity During an N-Back Task in Adults With Autism Spectrum Disorder

Cited by 11 publications

References 206 publications

Retained Primitive Reflexes and Potential for Intervention in Autistic Spectrum Disorders

Retained Primitive Reflexes and Potential for Intervention in Autistic Spectrum Disorders

Aberrant oscillatory activity in Neurofibromatosis Type 1: An EEG study of resting state and working memory

Frontoparietal connectivity, Sensory Features, and Anxiety in Children and Adolescents with Autism Spectrum Disorder

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