Frontoparietal connectivity correlates with working memory performance in multiple sclerosis

Figueroa-Vargas, Alejandra; Cárcamo, Claudia; Henríquez-Ch, Rodrigo A.; Zamorano, Francisco; Ciampi, Ethel; Uribe-San-Martín, Reinaldo; Vásquez, Mónica; Aboitiz, Francisco; Billeke, Pablo

doi:10.1038/s41598-020-66279-0

Cited by 29 publications

(33 citation statements)

References 86 publications

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“…In this context, it is relevant to mention reported working memory deficits in children with ADHD (Nikolas and Nigg, 2013). Working memory crucially depends on theta oscillation (Billeke et al, 2017;Larrain-Valenzuela et al, 2017;Figueroa-Vargas et al, 2020), and its impairment can preclude the adequate information maintaining necessary to exert general proactive cognitive control. In a broad sense, these functional results can be related to the functional differences observed in children with ADHD in prefrontal areas when compared to TD children (Nakao et al, 2011;Frodl and Skokauskas, 2012) and the difference between TD children according to age (Bruin et al, 2001;Jonkman, 2006;Spronk et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Lateral Prefrontal Theta Oscillations Reflect Proactive Cognitive Control Impairment in Males With Attention Deficit Hyperactivity Disorder

Zamorano

Kausel

Albornoz

et al. 2020

Front. Syst. Neurosci.

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Attention Deficit Hyperactivity Disorder (ADHD) is a common neuropsychiatric disorder in which children present prefrontal cortex (PFC) related functions deficit. Proactive cognitive control is a process that anticipates the requirement of cognitive control and crucially depends on the maturity of the PFC. Since this process is important to ADHD symptomatology, we here test the hypothesis that children with ADHD have proactive cognitive control impairments and that these impairments are reflected in the PFC oscillatory activity. We recorded EEG signals from 29 male children with ADHD and 25 typically developing (TD) male children while they performed a Go-Nogo task, where the likelihood of a Nogo stimulus increased while a sequence of consecutive Go stimuli elapsed. TD children showed proactive cognitive control by increasing their reaction time (RT) concerning the number of preceding Go stimuli, whereas children with ADHD did not. This adaptation was related to modulations in both P3a potential and lateral prefrontal theta oscillation for TD children. Children with ADHD as a group did not demonstrate either P3a or theta modulation. But, individual variation in theta activity was correlated with the ADHD symptomatology. The results depict a neurobiological mechanism of proactive cognitive control impairments in children with ADHD.

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Section: Discussionmentioning

confidence: 99%

Lateral Prefrontal Theta Oscillations Reflect Proactive Cognitive Control Impairment in Males With Attention Deficit Hyperactivity Disorder

Zamorano

Kausel

Albornoz

et al. 2020

Front. Syst. Neurosci.

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“…When the data did not meet the normal assumption, we used nonparametric tests. For the EEG statistical analysis, we rst tted a general linear model (GLM) of the power of the oscillatory activity per trial in each participant ( rst-level analysis, see [45][46][47][48] ) using the following equation:…”

Section: Discussionmentioning

confidence: 99%

Empathy concerns enhance prosociality and modulate frontal theta oscillatory activity in young adults

Lavin

Soto-Icaza

López

et al. 2021

Preprint

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Decision making is a process that can be strongly affected by social factors. Profuse evidence has shown how people deviate from traditional rational-choice predictions under different levels of social interactions. The emergence of prosocial decision making, defined as any action that is addressed to benefit another individual even at the expense of personal benefits, has been reported as an important example of such social influence. Furthermore, brain evidence has shown the involvement of structures such the prefrontal cortex, anterior insula and midcingulate cortex during decision settings in which a decision maker interacts with others under physical pain or distress or while being observed by others. Using a slightly modified version of the dictator game, we tested the hypothesis that the inclusion of another person into the decision setting increases prosocial decisions in young adults and that this increase is higher when the other person is associated with others in need. At the brain level, we hypothesized that the increase in prosocial decisions correlates with frontal theta activity as a marker of empathy saliency. The results showed that the inclusion of another person into the decision setting increased prosocial behavior only when this presence was associated with someone in need and that this was associated with an increase in frontocentral theta-oscillatory activity. These results suggest that the presence of someone in need enhances both empathy concerns and norm compliance, raising the participants’ prosocial decision making.

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“…A similar study in broad autism phenotype reports an effect size of f η 2 = 0.09 [ 68 ], which is a large effect [ 69 ]. Taking into account the publication bias, and our previous experience in effect size in electrophysiological measure in our experimental setting between clinical and subclinical populations [e.g., 70 , 71 ], we set an intermediated effect size of η 2 = 0.06. Thus, for the between-within factor interaction in a 2x4 mixed ANOVA with a power of (1-β) = 0.95 and a significant level of α = 0.05, the minimum sample size to find the expected effect was n = 36.…”

Section: Methodsmentioning

confidence: 99%

Differences in cortical processing of facial emotions in broader autism phenotype

et al. 2022

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Autism Spectrum Disorder (ASD) is a heterogeneous condition that affects face perception. Evidence shows that there are differences in face perception associated with the processing of low spatial frequency (LSF) and high spatial frequency (HSF) of visual stimuli between non-symptomatic relatives of individuals with autism (broader autism phenotype, BAP) and typically developing individuals. However, the neural mechanisms involved in these differences are not fully understood. Here we tested whether face-sensitive event related potentials could serve as neuronal markers of differential spatial frequency processing, and whether these potentials could differentiate non-symptomatic parents of children with autism (pASD) from parents of typically developing children (pTD). To this end, we performed electroencephalographic recordings of both groups of parents while they had to recognize emotions of face pictures composed of the same or different emotions (happiness or anger) presented in different spatial frequencies. We found no significant differences in the accuracy between groups but lower amplitude modulation in the Late Positive Potential activity in pASD. Source analysis showed a difference in the right posterior part of the superior temporal region that correlated with ASD symptomatology of the child. These results reveal differences in brain processing of recognition of facial emotion in BAP that could be a precursor of ASD.

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Frontoparietal connectivity correlates with working memory performance in multiple sclerosis

Cited by 29 publications

References 86 publications

Lateral Prefrontal Theta Oscillations Reflect Proactive Cognitive Control Impairment in Males With Attention Deficit Hyperactivity Disorder

Lateral Prefrontal Theta Oscillations Reflect Proactive Cognitive Control Impairment in Males With Attention Deficit Hyperactivity Disorder

Empathy concerns enhance prosociality and modulate frontal theta oscillatory activity in young adults

Differences in cortical processing of facial emotions in broader autism phenotype

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