Frontoparietal areas link impairments of large-scale intrinsic brain networks with aberrant fronto-striatal interactions in OCD: a meta-analysis of resting-state functional connectivity

Gürsel, Deniz A.; Avram, Mihai; Sorg, Christian; Brandl, Felix; Koch, Kathrin

doi:10.1016/j.neubiorev.2018.01.016

Cited by 175 publications

(179 citation statements)

References 64 publications

Supporting

Mentioning

164

Contrasting

Order By: Relevance

“…Hypogyrification across more of the frontoparietal cortex could, in turn, increase both vulnerability to AN and potential severity of AN by driving multi-dimensional deficits in cognitive and behavioral flexibility that manifest as body and foodrelated rumination and persistent food avoidance and hinder adaptive information processing necessary for treatment engagement. Reduced resting-state functional connectivity, consistent with this hypothesis, has been reported in remitted AN (Boehm et al, 2016), and it has also been observed in OCD (Guersel, Avram, Sorg, Brandl & Koch, 2018). Compounding effects of variations in cortical surface architecture associated with core AN symptomatology and set-shifting impairment could contribute to worse outcomes observed in AN patients with more pronounced cognitive-behavioral deficits (Steinhausen, 2002).…”

Section: Overlapping Associations Between Core An Symptomatology and supporting

confidence: 61%

Structural neuroimaging signatures of anorexia nervosa features in a mixed sample enriched for disease vulnerability

Miles

Kaplan

et al. 2018

Preprint

View full text Add to dashboard Cite

Brain-behavior relationships that could provide insight into risk-associated pathophysiology have not been thoroughly assessed in anorexia nervosa (AN). Therefore, we sought to identify grey and white matter signatures of AN symptoms and risk factors (trait anxiety, set-shifting impairment) in a sample enriched for AN vulnerability, including acute and remitted AN patients and their unaffected sisters (n = 72, aged 18 -48 years). MRI/DTI data were acquired on a 3T scanner and processed with Freesurfer and FSL TBSS. Relationships between clinical variables of interest and regional subcortical volume, vertexwise cortical surface architecture (thickness, surface area, local gyrification), and voxel-wise white matter microstructure (FA, MD) were tested with separate linear regressions, including age, BMI, lifetime AN diagnosis, and intracranial volume as covariates, where appropriate. Significance was determined using a Bonferroni-corrected threshold, p(t) ≤ 0.001. We detected distinct associations linking AN symptoms to lateral occipital cortical thickness and insular/cingulate gyrification and trait anxiety to lingual cortical thickness and superior parietal gyrification, and we detected overlapping associations linking AN symptoms and set-shifting impairment to frontoparietal gyrification. No other brain-behavior relationships emerged. Our findings suggest that variations in site-specific cortical morphology could give rise to core features of AN and shared temperamental and cognitive-behavioral risk factors for AN.

show abstract

Section: Overlapping Associations Between Core An Symptomatology and supporting

confidence: 61%

Structural neuroimaging signatures of anorexia nervosa features in a mixed sample enriched for disease vulnerability

Miles

Kaplan

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…The PCG forms part of the somatosensory cortex, which serves to integrate somatosensory information with emotional input from the amygdala and, together with the amygdala and right visual cortices, has been found to be important for linking perception of emotional stimuli to motivation (Adolphs, 2001;Adolphs, Damasio, Tranel, Cooper, & Damasio, 2000). Indeed, previous research in OCD patients has shown decreased functional connectivity in networks comprising the PCG (Gürsel, Avram, Sorg, Brandl, & Koch, 2018;Moreira et al, 2017). Indeed, previous research in OCD patients has shown decreased functional connectivity in networks comprising the PCG (Gürsel, Avram, Sorg, Brandl, & Koch, 2018;Moreira et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…The right somatosensory cortex, for instance, has been shown to be active during the processing of incongruent somatosensory-emotional information (i.e., incongruent facial and voice expressions) (Klasen, Kenworthy, Mathiak, Kircher, & Mathiak, 2011). Indeed, previous research in OCD patients has shown decreased functional connectivity in networks comprising the PCG (Gürsel, Avram, Sorg, Brandl, & Koch, 2018;Moreira et al, 2017). In addition, the altered functional connectivity between the somatosensory cortex and the amygdala seems to be underpinned by an abnormal pattern of structural connectivity between these regions, since we observed increased MD in the right corticospinal tract, in agreement with previous reports in other OCD samples (Fontenelle et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Intrinsic functional and structural connectivity of emotion regulation networks in obsessive-compulsive disorder

et al. 2018

View full text Add to dashboard Cite

Despite emotion regulation being altered in patients with obsessive-compulsive disorder (OCD), no studies have investigated its relation to multimodal amygdala connectivity. We compared corticolimbic functional and structural connectivity between OCD patients and healthy controls (HCs), and correlated this with the dispositional use of emotion regulation strategies and with OCD severity.OCD patients (n = 73) and HCs (n = 42) were assessed for suppression and reappraisal strategies using the Emotion Regulation Questionnaire (ERQ) and for OCD severity using the Yale-Brown Obsessive-Compulsive Scale. Resting-state functional magnetic resonance imaging (rs-fMRI) connectivity maps were generated using subject-specific left amygdala (LA) and right amygdala (RA) masks. We identified between-group differences in amygdala whole-brain connectivity, and evaluated the moderating effect of ERQ strategies. Significant regions and amygdala seeds were used as targets in probabilistic tractography analysis.Patients scored higher in suppression and lower in reappraisal. We observed higher rs-fMRI RAright postcentral gyrus (PCG) connectivity in HC, and in patients this was correlated with symptom severity. Reappraisal scores were associated with higher negative LA-left insula connectivity in HC, and suppression scores were negatively associated with LA-precuneus and angular gyri connectivity in OCD. Structurally, patients showed higher mean diffusivity in tracts connecting the amygdala with the other targets.RA-PCG connectivity is diminished in patients, while disrupted emotion regulation is related to altered amygdala connectivity with the insula and posterior brain regions. Our results are the first showing, from a multimodal perspective, the association between amygdala connectivity and specific emotional processing domains, emphasizing the importance of amygdala connectivity in OCD pathophysiology. 110

show abstract

“…Harrison et al () used resting‐state functional MRI and found abnormal activation in connections between striatum and orbitofrontal cortex. A meta‐analysis by Guersel, Avram, Sorg, Brandl, and Koch () revealed disrupted fronto‐stratal circuits and impaired large‐scale fronto‐parietal‐limbic brain networks in patients with OCD. Further, cortico–striatal–thalamic–cortical (CSTC) circuit has been identified as a decisive imaging marker for OCD diagosis.…”

Section: Introductionmentioning

confidence: 99%

Modeling essential connections in obsessive–compulsive disorder patients using functional MRI

Xing

Jin

et al. 2020

Brain and Behavior

View full text Add to dashboard Cite

Object: Obsessive-compulsive disorder (OCD) is a mental disease in which people experience uncontrollable and repetitive thoughts or behaviors. Clinical diagnosis of OCD is achieved by using neuropsychological assessment metrics, which are often subjectively affected by psychologists and patients. In this study, we propose a classification model for OCD diagnosis using functional MR images.Methods: Using functional connectivity (FC) matrices calculated from brain region of interest (ROI) pairs, a novel Riemann Kernel principal component analysis (PCA) model is employed for feature extraction, which preserves the topological information in the FC matrices. Hierarchical features are then fed into an ensemble classifier based on the XGBoost algorithm. Finally, decisive features extracted during classification are used to investigate the brain FC variations between patients with OCD and healthy controls. Results:The proposed algorithm yielded a classification accuracy of 91.8%.Additionally, the well-known cortico-striatal-thalamic-cortical (CSTC) circuit and cerebellum were found as highly related regions with OCD. To further analyze the cerebellar-related function in OCD, we demarcated cerebellum into three subregions according to their anatomical and functional property. Using these three functional

show abstract

Frontoparietal areas link impairments of large-scale intrinsic brain networks with aberrant fronto-striatal interactions in OCD: a meta-analysis of resting-state functional connectivity

Cited by 175 publications

References 64 publications

Structural neuroimaging signatures of anorexia nervosa features in a mixed sample enriched for disease vulnerability

Structural neuroimaging signatures of anorexia nervosa features in a mixed sample enriched for disease vulnerability

Intrinsic functional and structural connectivity of emotion regulation networks in obsessive-compulsive disorder

Modeling essential connections in obsessive–compulsive disorder patients using functional MRI

Contact Info

Product

Resources

About