Fronto–Temporal Disconnectivity in Schizotypal Personality Disorder: A Diffusion Tensor Imaging Study

Nakamura, Motoaki; McCarley, Robert W.; Kubicki, Marek; Dickey, Chandlee C.; Niznikiewicz, Margaret; Voglmaier, Martina M.; Seidman, Larry J.; Maier, Stephan E.; Westin, Carl‐Fredrik; Kikinis, Ron; Shenton, Martha E.

doi:10.1016/j.biopsych.2005.04.016

Cited by 107 publications

(112 citation statements)

References 68 publications

(89 reference statements)

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“…47 With the tractography approach and the seed points used in the present study, we most probably tracked two WM bundles, notably the UF, linking the SC and AH region and the medial cerebellar peduncle connecting the pons and the left and right cerebellum. As already stated above, the UF is a ventral-limbic pathway that connects rostral temporal, inferotemporal and ventral temporal regions, including the central nuclei of the amygdala and the parahippocampal gyrus, with the medial and orbitofrontal cortices and the subcallosal region (that is, area 25 31,48,49 ). It can be easily confounded with the inferior fronto-occipital fasciculus (IFO), 25 as it intermingles with the UF in the region of the extreme and external capsule.…”

Section: Diffusion Tensor Tractography In Bipolar Patients J Houenou mentioning

confidence: 94%

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

et al. 2007

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Bipolar disorder has been associated with anatomical as well as functional abnormalities in a brain network that mediates normal and impaired emotion regulation. Previous brain imaging studies have highlighted the subgenual cingulate (SC) and the amygdalo-hippocampal (AH) complex as core regions of this network. Thus we investigated white matter (WM) fiber tracts between the SC and the AH region, the uncinate fasciculus, as well as between two control regions (pons and cerebellum), using diffusion tensor imaging tractography in 16 euthymic bipolar patients (BP) and 16 sex-, age-and handedness-matched controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the reconstructed fiber bundle and the number of virtual reconstructed fibers were compared between groups. The tractography results revealed a significantly increased number of reconstructed fibers between the left SC and left AH in BP as compared to healthy controls. FA and ADC of the reconstructed fiber tract did not differ significantly between the groups. Furthermore, no significant group differences were observed neither for reconstructed fiber tracts between the right SC and right AH nor between the control regions. The present results suggest an altered WM pathway between the left SC and AH region and thus extend previous findings of anatomical and functional modifications in these structures in BP.

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Section: Diffusion Tensor Tractography In Bipolar Patients J Houenou mentioning

confidence: 94%

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

et al. 2007

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“…Extreme/abnormal personality traits (especially temperaments) are common characteristics of a wide spectrum of prevalent personality and psychiatric disorders (Richter and Brandstrom, 2009;Svrakic et al, 1993), such as depression (Celikel et al, 2009;Farmer et al, 2003;Sandi and Richter-Levin, 2009), bipolar disorder (Olvera et al, 2009), borderline personality disorder (Barnow et al, 2007), obsessive-compulsive disorder (Ettelt et al, 2008), and schizophrenia (Hori et al, 2008;Smith et al, 2008). These disorders have been found to be accompanied by abnormal/pathological neurobiological changes in the brain (Hazlett et al, 2005;Nakamura et al, 2005). In order to have a better understanding of the neurobiological basis of temperaments and a deeper insight into the pathogenesis of the temperament-related neuropsychiatric disorders, the current study investigated the associations between temperaments and fiber connectivity from the cortical and subcortical regions to the striatum.…”

Section: Introductionmentioning

confidence: 99%

Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

et al. 2014

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“…The basis for the cognitive impairment in schizophrenia is complex; it has principally been related to diminished or dysregulated brain dopaminergic (Weinberger et al, 1988), noradrenergic (Arnsten and Li, 2005), cholinergic (Meltzer and McGurk, 1999;Bymaster et al, 2002), glutamatergic (Hirsch et al, 1997), and g-aminobutyric acid (GABA) activity (Benes and Berretta, 2000), to neuronal or neuropil loss (Selemon and GoldmanRakic, 1999), and to abnormalities in connectivity (Pantelis et al, 1997;Nakamura et al, 2005). Thus, the ability of atypical antipsychotic drugs to preferentially increase extracellular efflux of dopamine (DA), norepinephrine (NE), and acetylcholine (ACh) in the medial prefrontal cortex (mPFC) and hippocampus (HIP) has been postulated to contribute to their ability to improve cognition, in schizophrenia, and possibly negative symptoms and depression (Assie et al, 2005;Devoto et al, 2004;Ichikawa et al, 1998;Ichikawa et al, 2002a, b, c;Kuroki et al, 1999;Zhang et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Asenapine Increases Dopamine, Norepinephrine, and Acetylcholine Efflux in the Rat Medial Prefrontal Cortex and Hippocampus

Huang

Dai

et al. 2008

Neuropsychopharmacol

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Atypical antipsychotic drugs, which are more potent direct acting antagonists of brain serotonin (5-HT) 2A than dopamine (DA) D 2 receptors, preferentially enhance DA and acetylcholine (ACh) efflux in the rat medial prefrontal cortex (mPFC) and hippocampus (HIP), compared with the nucleus accumbens (NAc). These effects may contribute to their ability, albeit limited, to improve cognitive function and negative symptoms in patients with schizophrenia. Asenapine (ASE), a new multireceptor antagonist currently in development for the treatment of schizophrenia and bipolar disorder, has complex serotonergic properties based upon relatively high affinity for multiple serotonin (5-HT) receptors, particularly 5-HT 2A and 5-HT 2C receptors. In the current study, the effects of ASE on DA, norepinephrine (NE), 5-HT, ACh, glutamate, and g-aminobutyric acid (GABA) efflux in rat mPFC, HIP, and NAc were investigated with microdialysis in awake, freely moving rats. ASE at 0.05, 0.1, and 0.5 mg/kg (s.c.), but not 0.01 mg/kg, significantly increased DA efflux in the mPFC and HIP. Only the 0.5 mg/kg dose enhanced DA efflux in the NAc. ASE, at 0.1 and 0.5 mg/kg, significantly increased ACh efflux in the mPFC, but only the 0.5 mg/kg dose of ASE increased HIP ACh efflux. ASE did not increase ACh efflux in the NAc at any of the doses tested. The effect of ASE (0.1 mg/kg) on DA and ACh efflux was blocked by pretreatment with WAY100635, a 5-HT 1A antagonist/D 4 agonist, suggesting involvement of indirect 5-HT 1A agonism in both the actions. ASE, at 0.1 mg/kg, increased NE, but not 5-HT, efflux in the mPFC and HIP. ASE, at 0.1 mg/kg (s.c.), had no effect on glutamate and GABA efflux in either the mPFC or NAc. These findings indicate that ASE is similar to clozapine and other atypical antipsychotic drugs in preferentially increasing the efflux of DA, NE, and ACh in the mPFC and HIP compared with the NAC, and suggests that, like these agents, it may also improve cognitive function and negative symptoms in patients with schizophrenia.

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Fronto–Temporal Disconnectivity in Schizotypal Personality Disorder: A Diffusion Tensor Imaging Study

Abstract: These findings in SPD suggest altered fronto-temporal connectivity through the UF, similar to findings in schizophrenia, and intact neocortical-limbic connectivity through the CB, in marked contrast with what has been reported in schizophrenia.

Cited by 107 publications

References 68 publications

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

Asenapine Increases Dopamine, Norepinephrine, and Acetylcholine Efflux in the Rat Medial Prefrontal Cortex and Hippocampus

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