Fronto-temporal connectivity in never-medicated patients with first-episode schizophrenia: A DTI study

Disturbances in White Matter Integrity in the Ultra-High-Risk Psychosis State—A Systematic Review

“…The initially available evidence suggested that 22–36% of UHR individuals convert to psychosis after 1–3 years [ 77 ], but the transition rates have been declining in more recent studies and vary between 16.9% after 2 years [ 78 ], 24% after 3 years [ 79 ], and 14.6% over a median follow-up time of 4.8 years [ 80 ], depending on the research; hence the need to conduct research on a large number of at-risk patients, possibly separately for the BLIPS, APS, and GDR subgroups. Analyses comparing UHR not only with HC but also FEP individuals or those recently diagnosed with schizophrenia suggest similar or less severe WM alterations in UHR relative to the other groups [ 34 , 43 , 48 , 53 , 81 , 82 ], which suggests that they may occur even prior to the onset of illness. The very process of identifying UHR based on the use of structured interviews (SIPS, CAARMS) assumes that symptoms can be qualitatively assessed and that there exists a cut-off point above which symptoms can be considered psychotic and, if the duration criteria are met, the patient is thus diagnosed with acute psychosis, supporting the concept of a “psychosis continuum” [ 83 , 84 ].…”