Fronto-temporal Connectivity in Bipolar Disorder and Schizophrenia Related to Auditory Verbal Hallucinations

Auditory verbal hallucinations in bipolar disorder (BD) and major depressive disorder (MDD): A systematic review

“…In mood disorders, it seems that AVHs commonly co-occur with delusions, notably with persecutory themes, suggesting shared involvement of psychosis-related processes. In terms of mechanisms, a single known neuroimaging study has suggested increased connectivity between the DLPFC and Broca's area as well as left SMTG, and between the left SMTG and bilateral ACC as related to AVHs in BD (Sprooten et al, 2009). No further conclusions could be drawn, though this finding is consistent with some previous work in Sz.…”

“…Of these studies, seven employed BD and/or MDD as the focus clinical group (Baethge et al, 2005;Black and Nasrallah, 1989;Braunig et al, 2009;Hammersley et al, 2003;Hammersley et al, 2010;Tillman et al, 2008;Winokur et al, 1985), three described investigations of AVHs across diagnostic groups (Okulate and Jones, 2003;Schreier, 1998;Sprooten et al, 2009), and the rest focused on Sz, with BD and/or MDD as the clinical control group. Not all studies reported separate results for BD and MDD; some combined mood disorder participants with hallucinations into an affective psychosis (AP) group.…”

“…In the only known neuroimaging study of AVHs in BD, Sprooten et al (2009) found that both BD and Sz patients with a history of AVHs showed increased connectivity between the right dorsolateral prefrontal cortex (DLPFC) and Broca's area as well as left superior and middle temporal gyrus (SMTG). In addition, the left SMTG had increased connectivity with bilateral anterior cingulate cortex (ACC).…”

“…Yet given the role of mood in contributing to AVH manifestations in BD and MDD, the function of mood disturbance and its interaction with these mechanisms, need to be incorporated into these models. Likewise, there has been scant neuroimaging research, with only a single study to date examining the neural correlates of AVHs in BD (Sprooten et al, 2009). Given the proliferation of neuroimaging studies of AVHs in Sz, and concomitant therapeutic applications (e.g.…”

09 - Functional Connectivity Between Dorsolateral Prefrontal Cortex and Left Temporal Language-Related Region in the First-Degree Relatives of Patients With Schizophrenia

“…[1], [2], [3], [4] It seems, however, that the analysis of similar FC in the genetic risk group has yet to be done.…”