Fronto-limbic dysfunction in borderline personality disorder: A 18F-FDG positron emission tomography study

Salavert, J.; Gasol, Miquel; Vieta, Eduard; Cervantes, Ana; Trampal, Carlos; Gispert, Juan Domingo

doi:10.1016/j.jad.2011.01.001

Cited by 48 publications

(28 citation statements)

References 45 publications

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“…However, one PET study has reported increased activity in female BPD patients bilaterally in the AC and in the right IFG although this may reflect co-morbidity with OCD/depression in many patients (Juengling et al, 2003). Another PET study with a small number of patients ( n = 8) without co-morbidities has reported similar findings (Salavert et al, 2011) as well as hypometabolism in the PCC and precuneus. Thus the pattern of resting-state changes in the CMS is not entirely consistent and needs to be confirmed with appropriate account being taken of potential co-morbidity contributions.…”

Section: Self-processing In Borderline Personality Disordersupporting

confidence: 65%

What Can Psychiatric Disorders Tell Us about Neural Processing of the Self?

Zhao

Luo

et al. 2013

Front. Hum. Neurosci.

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Many psychiatric disorders are associated with abnormal self-processing. While these disorders also have a wide-range of complex, and often heterogeneous sets of symptoms involving different cognitive, emotional, and motor domains, an impaired sense of self can contribute to many of these. Research investigating self-processing in healthy subjects has facilitated identification of changes in specific neural circuits which may cause altered self-processing in psychiatric disorders. While there is evidence for altered self-processing in many psychiatric disorders, here we will focus on four of the most studied ones, schizophrenia, autism spectrum disorder (ASD), major depression, and borderline personality disorder (BPD). We review evidence for dysfunction in two different neural systems implicated in self-processing, namely the cortical midline system (CMS) and the mirror neuron system (MNS), as well as contributions from altered inter-hemispheric connectivity (IHC). We conclude that while abnormalities in frontal-parietal activity and/or connectivity in the CMS are common to all four disorders there is more disruption of integration between frontal and parietal regions resulting in a shift toward parietal control in schizophrenia and ASD which may contribute to the greater severity and delusional aspects of their symptoms. Abnormalities in the MNS and in IHC are also particularly evident in schizophrenia and ASD and may lead to disturbances in sense of agency and the physical self in these two disorders. A better future understanding of how changes in the neural systems sub-serving self-processing contribute to different aspects of symptom abnormality in psychiatric disorders will require that more studies carry out detailed individual assessments of altered self-processing in conjunction with measurements of neural functioning.

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Section: Self-processing In Borderline Personality Disordersupporting

confidence: 65%

What Can Psychiatric Disorders Tell Us about Neural Processing of the Self?

Zhao

Luo

et al. 2013

Front. Hum. Neurosci.

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“…First, we conducted a meta-analysis to identify the main effect of BPD diagnosis on task-independent neural function. Second, we carried out two further metaanalyses based on the imaging modality: fMRI studies (Das et al, 2014;; Doll et al, 2013;; Salvador et al, 2016;; Wolf et al, 2011) and PET studies (Lange et al, 2005;; Salavert et al, 2011;; Soloff et al, 2005) (Table S.1). Meta-analyses were performed separately for the BPD>HC and the HC>BPD contrasts using SDM software (Signed Differential Mapping, www.sdmproject.com).…”

Section: Methodsmentioning

confidence: 99%

Mapping the brain correlates of borderline personality disorder: A functional neuroimaging meta-analysis of resting state studies

Visintin

Panfilis

Amore

et al. 2016

Journal of Affective Disorders

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To investigate the neural activity at rest in BPD, we conducted a set of meta-analyses of brain imaging studies performed at rest. A total of seven functional imaging studies (152 patients with BPD and 147 control subjects) were combined using whole-brain Signed Differential Mapping meta-analyses. Furthermore, two conjunction meta-analyses of neural activity at rest were also performed: with neural activity changes during emotional processing and with structural differences, respectively. We found altered neural activity in the regions of the default mode network (DMN) in BPD. Within the regions of the core DMN, patients with BPD showed greater activity in the anterior as well as in the posterior midline hubs relative to controls. Conversely, in the regions of the dorsal DMN they showed reduced activity compared to controls in the right lateral temporal complex and in bilateral orbitofrontal cortex. Increased activity in the precuneus was observed both at rest and during emotional processing. Reduced neural activity at rest in lateral temporal complex was associated with smaller volume of this area.Altered activity in the regions of the midline core as well as of the dorsal subsystem of the DMN may reflect difficulties with interpersonal and affective regulation in BPD. These findings suggest that changes in spontaneous neural activity could underlie core symptoms in BPD.

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“…2 Neuroimaging studies and psycho physiological research into emotional responses have indicated that BPD is characterized by elevated and prolonged levels of negative emotional responses, especially to threatening stimuli associated with abuse or abandonment. 3,4 In neuroimaging studies, the experience of strong negative emotions in patients with BPD is reflected by frontolimbic dysfunctions 5 (i.e., increased amygdala and hippocampal responses to threatening stimuli, [6][7][8][9] reduced anterior cingulate [ACC] and prefrontal cortical activations [9][10][11] emotional stimuli are usually stressful and negatively valenced pictures from the International Affective Picture System. 12 In particular, the emotion of anger has rarely been investigated, which is surprising given that exaggerated anger is a diagnostic criterion of BPD.…”

Section: Introductionmentioning

confidence: 99%