Frontispiece: Dynamically Re‐Organized Collagen Fiber Bundles Transmit Mechanical Signals and Induce Strongly Correlated Cell Migration and Self‐Organization

Fan, Qihui; Zheng, Yu; Wang, Xiaochen; Xie, Ruipei; Wang, Boyi; Lu, Yu; Liu, Liyu; Li, Yunliang; Li, Ming; Zhao, Yuanjin; Jiao, Yang; Ye, Fangfu

doi:10.1002/anie.202182162

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“…Recent experimental and computational studies have revealed that migrating cells in mesenchymal mode in 3D ECM can generate active pulling forces via actin filament contraction within the cells. Such active forces are then transmitted to the ECM network via focal adhesion complexes [ 17 – 21 ] and are able to propagate to an extended range in the ECM, due to the random and network-like nature of the ECM [ 22 – 25 ]. However, the influences of ECM and the long-range forces therein on the patterning of coculture systems remain unexplored.…”

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confidence: 99%

Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems

et al. 2021

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Studies on pattern formation in coculture cell systems can provide insights into many physiological and pathological processes. Here, we investigate how the extracellular matrix (ECM) may influence the patterning in coculture systems. The model coculture system we use is composed of highly motile invasive breast cancer cells, initially mixed with inert nonmetastatic cells on a 2D substrate and covered with a Matrigel layer introduced to mimic ECM. We observe that the invasive cells exhibit persistent centripetal motion and yield abnormal aggregation, rather than random spreading, due to a “collective pulling” effect resulting from ECM-mediated transmission of active contractile forces generated by the polarized migration of the invasive cells along the vertical direction. The mechanism we report may open a new window for the understanding of biological processes that involve multiple types of cells.

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Section: Introductionmentioning

confidence: 99%

Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems

et al. 2021

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Frontispiece: Dynamically Re‐Organized Collagen Fiber Bundles Transmit Mechanical Signals and Induce Strongly Correlated Cell Migration and Self‐Organization

Abstract: Fibrous Proteins In their Research Article on page 11858, Yuanjin Zhao, Yang Jiao, Fangfu Ye et al. report the organization of collagen fiber bundles. The bundles transmit mechanical signals and induce strongly correlated cell migration.

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Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems

Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems

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