Frontispiece: Cyanine Dyes Containing Quinoline Moieties: History, Synthesis, Optical Properties, and Applications

Ilina, Kristina; Henary, Maged

doi:10.1002/chem.202181361

Cited by 3 publications

(8 citation statements)

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“…This chain is constituted of sp 2 -hybridized carbon atoms. Depending on the number of methine groups of this chain, cyanines can be categorized as monomethine (Cy1), trimethine (Cy3), pentamethine (Cy5) or heptamethine (Cy7) cyanines [54].…”

Section: Cyanine Dye-based Photosensitizersmentioning

confidence: 99%

Polymethine dyes for PDT: recent advances and perspectives to drive future applications

Dereje

Pontremoli

Plata

et al. 2022

Photochem Photobiol Sci

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It has been proved that the effectiveness of photodynamic therapy (PDT) is closely related to the intrinsic features of the photosensitizer (PS). Over the recent years, several efforts have been devoted to the discovery of novel and more efficient photosensitizers showing higher efficacy and lower side effects. In this context, squaraine and cyanine dyes have been reported to potentially overcome the drawbacks related to the traditional PSs. In fact, squaraines and cyanines are characterized by sharp and intense absorption bands and narrow emission bands with high extinction coefficients typically in the red and near-infrared region, good photo and thermal stability and a strong fluorescent emission in organic solvents. In addition, biocompatibility and low toxicity make them suitable for biological applications. Despite these interesting intrinsic features, their chemical instability and self-aggregation properties in biological media still limit their use in PDT. To overcome these drawbacks, the self-assembly and incorporation into smart nanoparticle systems are forwarded promising approaches that can control their physicochemical properties, providing rational solutions for the limitation of free dye administration in the PDT application. The present review summarizes the latest advances in squaraine and cyanine dyes for PDT application, analyzing the different strategies, i.e.the self-assembly and the incorporation into nanoparticles, to further enhance their photochemical properties and therapeutic potential. The in vivo assessments are still limited, thus further delaying their effective application in PDT. Graphical abstract

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Section: Cyanine Dye-based Photosensitizersmentioning

confidence: 99%

Polymethine dyes for PDT: recent advances and perspectives to drive future applications

Dereje

Pontremoli

Plata

et al. 2022

Photochem Photobiol Sci

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“…As a senior expert in dye chemistry, I am familiar with similar incomplete “definitions” well enough and would have ignored them, but then I saw the ”symmetrical dimethine cyanine dyes“ 36 and 37 in the review [6] …”

Section: Conflict Of Interestmentioning

confidence: 99%

“…The heading of the review begins with “Cyanine Dyes …”, however, the CYANINE dye in Figure 6 [6] is called Quinoline Blue. Why?…”

Section: Conflict Of Interestmentioning

confidence: 99%

“…As a senior expert in dye chemistry, I am familiar with similar incomplete "definitions" well enough and would have ignored them, but then I saw the "symmetrical dimethine cyanine dyes" 36 and 37 in the review. [6] It is correct that one structural element of cyanine dyes is a conjugated chain of sp 2 -hybridized carbon atoms À C(X)À C(X) (X represents H, as drawn in the general formula 1, alkyl, halogen, aryl, heteroaryl or part of a separate unsaturated heterocyclic system) linking two terminal nitrogen atoms, where each nitrogen atom and part of the conjugated chain form part of an unsaturated heterocyclic system.…”

mentioning

confidence: 99%

“…Furthermore, we can read in the review: [6] "Charles Hanson Greville Williams synthesized the first cyanine dye in 1856. Williams obtained quinoline by distillation of cinchonine and heated the distillate with amyl iodide and an excess of ammonia, which resulted in "a magnificent blue color" compound, called Quinoline Blue, which is illustrated in Figure 6.…”

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confidence: 99%

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Correspondence on “Cyanine Dyes Containing Quinoline Moieties: History, Synthesis, Optical Properties and Applications”

Mustroph¹

2022

Chemistry A European J

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Fluorescent Tracers for In Vivo Imaging of Lymphatic Targets

et al. 2022

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The lymphatic system continues to gain importance in a range of conditions, and therefore, imaging of lymphatic vessels is becoming more widespread for research, diagnosis, and treatment. Fluorescent lymphatic imaging offers advantages over other methods in that it is affordable, has higher resolution, and does not require radiation exposure. However, because the lymphatic system is a one-way drainage system, the successful delivery of fluorescent tracers to lymphatic vessels represents a unique challenge. Each fluorescent tracer used for lymphatic imaging has distinct characteristics, including size, shape, charge, weight, conjugates, excitation/emission wavelength, stability, and quantum yield. These characteristics in combination with the properties of the target tissue affect the uptake of the dye into lymphatic vessels and the fluorescence quality. Here, we review the characteristics of visible wavelength and near-infrared fluorescent tracers used for in vivo lymphatic imaging and describe the various techniques used to specifically target them to lymphatic vessels for high-quality lymphatic imaging in both clinical and pre-clinical applications. We also discuss potential areas of future research to improve the lymphatic fluorescent tracer design.

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Frontispiece: Cyanine Dyes Containing Quinoline Moieties: History, Synthesis, Optical Properties, and Applications

Cited by 3 publications

References 0 publications

Polymethine dyes for PDT: recent advances and perspectives to drive future applications

Polymethine dyes for PDT: recent advances and perspectives to drive future applications

Correspondence on “Cyanine Dyes Containing Quinoline Moieties: History, Synthesis, Optical Properties and Applications”

Fluorescent Tracers for In Vivo Imaging of Lymphatic Targets

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