Frontispiece: 8‐Oxo‐7,8‐dihydroadenine and 8‐Oxo‐7,8‐dihydroadenosine—Chemistry, Structure, and Function in RNA and Their Presence in Natural Products and Potential Drug Derivatives
Abstract:A description and history of the role that 8‐oxo‐7,8‐dihydroadenine (8‐oxoAde) and 8‐oxo‐7,8‐dihydroadenosine (8‐oxoA) have in various fields is provided. This article focuses on 1) the formation of this oxidatively generated modification in RNA, its interactions with other biopolymers, and its potential role in the development/progression of disease; 2) the independent synthesis and incorporation of this modified nucleoside into oligonucleotides of RNA to display the progress that has been made in establishin… Show more
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