Frontiers of MicroRNA Signature in Non-small Cell Lung Cancer

Zhu, Xinping; Kudo, M.; Huang, Xiangjie; Sui, Hehuan; Tian, Haishan; Croce, Carlo M.; Cui, Ri

doi:10.3389/fcell.2021.643942

Cited by 41 publications

(41 citation statements)

References 123 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Microrna (Mirna)mentioning

confidence: 99%

“…They act as gene regulator by binding to mRNAs and inhibiting their functions ( 205 ). Plenty of studies revealed that miRNAs play significant roles, including both oncogenes and tumor suppressors, during the progression and metastasis of lung cancer ( 206 – 208 ). Overexpression of the let-7 family, miR-486, miR-218, miR-34, and miR-200 were proved to inhibit the tumor cell proliferation, invasion and colony formation, though there is no specific article describing their relations with tumor cells bone migration ( 209 – 212 ).…”

Section: Other Potential Biomarkersmentioning

confidence: 99%

See 1 more Smart Citation

Predictive and Prognostic Biomarkers for Lung Cancer Bone Metastasis and Their Therapeutic Value

et al. 2021

View full text Add to dashboard Cite

Lung cancer is the leading cause of cancer-related death worldwide. Bone metastasis, which usually accompanies severe skeletal-related events, is the most common site for tumor distant dissemination and detected in more than one-third of patients with advanced lung cancer. Biopsy and imaging play critical roles in the diagnosis of bone metastasis; however, these approaches are characterized by evident limitations. Recently, studies regarding potential biomarkers in the serum, urine, and tumor tissue, were performed to predict the bone metastases and prognosis in patients with lung cancer. In this review, we summarize the findings of recent clinical research studies on biomarkers detected in samples obtained from patients with lung cancer bone metastasis. These markers include the following: (1) bone resorption-associated markers, such as N-terminal telopeptide (NTx)/C-terminal telopeptide (CTx), C-terminal telopeptide of type I collagen (CTx-I), tartrate-resistant acid phosphatase isoform 5b (TRACP-5b), pyridinoline (PYD), and parathyroid hormone related peptide (PTHrP); (2) bone formation-associated markers, including total serum alkaline phosphatase (ALP)/bone specific alkaline phosphatase(BAP), osteopontin (OP), osteocalcin (OS), amino-terminal extension propeptide of type I procollagen/carboxy-terminal extension propeptide of type I procollagen (PICP/PINP); (3) signaling markers, including epidermal growth factor receptor/Kirsten rat sarcoma/anaplastic lymphoma kinase (EGFR/KRAS/ALK), receptor activator of nuclear factor κB ligand/receptor activator of nuclear factor κB/osteoprotegerin (RANKL/RANK/OPG), C-X-C motif chemokine ligand 12/C-X-C motif chemokine receptor 4 (CXCL12/CXCR4), complement component 5a receptor (C5AR); and (4) other potential markers, such as calcium sensing receptor (CASR), bone sialoprotein (BSP), bone morphogenetic protein 2 (BMP2), cytokeratin 19 fragment/carcinoembryonic antigen (CYFRA/CEA), tissue factor, cell-free DNA, long non-coding RNA, and microRNA. The prognostic value of these markers is also investigated. Furthermore, we listed some clinical trials targeting hotspot biomarkers in advanced lung cancer referring for their therapeutic effects.

show abstract

Section: Microrna (Mirna)mentioning

confidence: 99%

Section: Other Potential Biomarkersmentioning

confidence: 99%

Predictive and Prognostic Biomarkers for Lung Cancer Bone Metastasis and Their Therapeutic Value

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Non-small cell lung cancer (NSCLC) is a lethal cancer that causes over 1 million deaths a year (Torre et al, 2015;Yan et al, 2020;Zhu et al, 2021). Recently, the rising incidence of lung adenocarcinoma (LUAD), a major type of NSCLC, has become such a concerning issue that tends to surpass lung squamous carcinoma (Tong et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Identification of a Novel Prognostic Signature of Genome Instability-Related LncRNAs in Early Stage Lung Adenocarcinoma

Peng

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

BackgroundIncreasing evidence has demonstrated that long non-coding RNAs (lncRNAs) play a crucial part in maintaining genomic instability. We therefore identified genome instability-related lncRNAs and constructed a prediction signature for early stage lung adenocarcinoma (LUAD) as well in order for classification of high-risk group of patients and improvement of individualized therapies.MethodsEarly stage LUAD RNA-seq and clinical data from The Cancer Genome Atlas (TCGA) were randomly divided into training set (n = 177) and testing set (n = 176). A total of 146 genomic instability-associated lncRNAs were identified based on somatic mutation profiles combining lncRNA expression profiles from TCGA by the “limma R” package. We performed Cox regression analysis to develop this predictive indicator. We validated the prognostic signature by an external independent LUAD cohort with microarray platform acquired from the Gene Expression Omnibus (GEO).ResultsA genome instability-related six-lncRNA-based gene signature (GILncSig) was established to divide subjects into high-risk and low-risk groups with different outcomes at statistically significant levels. According to the multivariate Cox regression and stratification analysis, the GILncSig was an independent predictive factor. Furthermore, the six-lncRNA signature achieved AUC values of 0.745, 0.659, and 0.708 in the training set, testing set, and TCGA set, respectively. When compared with other prognostic lncRNA signatures, the GILncSig also exhibited better prediction performance.ConclusionThe prognostic lncRNA signature is a potent tool for risk stratification of early stage LUAD patients. Our study also provided new insights for identifying genome instability-related cancer biomarkers.

show abstract

“…In non‐small cell lung cancer (NSCLC), miR‐21 is upregulated in cancer tissue and therefore had been considered as a promising diagnostic and therapeutic marker in NSCLC. 8 However, emerging studies revealed that many miRNAs exhibit dual roles in different cellular contexts. 9 , 10 Specially in cancer, some miRNAs are reported to exert contrary oncogenic or tumor‐suppressive functions, relying on whether their targets are potential tumor suppressors or oncogenes.…”

Section: Introductionmentioning

confidence: 99%

Hsa‐miR‐335 enhances cell migration and invasion in lung adenocarcinoma through targeting Copine‐1

Wang

Zhang

Zhong

et al. 2021

MedComm

View full text Add to dashboard Cite

Lung adenocarcinoma (LAC) is one of the most common pulmonary adenocarcinomas with a high peak of mortality, and metastasis is the main culprit of LAC deaths. microRNAs play important role in cancer metastasis, and thus are regarded as potential diagnostic and prognostic markers for human cancers. However, many miRNAs exhibit dual roles in diverse cellular contexts. Here, we revealed that hsa‐miR‐335, a previously reported tumor suppressor, exhibited an oncogenic role in LAC. Overexpression of miR‐335 enhanced the abilities of A549 and H1299 cells to invade and migrate by regulating epithelial‐mesenchymal transition, while inhibition of miR‐335 exhibited an opposite effect in vitro and in vivo. Mechanically, miR‐335 inhibited the expression of Copine‐1 (CPNE1), an NF‐κB suppressor, through interacting with its mRNA 3′UTR, while mutating the binding sites abolished this inhibitory effect. This finding not only highlights the suppressive effect of CPNE1 on cell motility, but also provides new insight into miR‐335 in promoting LAC metastasis.

show abstract

Frontiers of MicroRNA Signature in Non-small Cell Lung Cancer

Cited by 41 publications

References 123 publications

Predictive and Prognostic Biomarkers for Lung Cancer Bone Metastasis and Their Therapeutic Value

Predictive and Prognostic Biomarkers for Lung Cancer Bone Metastasis and Their Therapeutic Value

Identification of a Novel Prognostic Signature of Genome Instability-Related LncRNAs in Early Stage Lung Adenocarcinoma

Hsa‐miR‐335 enhances cell migration and invasion in lung adenocarcinoma through targeting Copine‐1

Contact Info

Product

Resources

About