Frontiers of Medical Micro/Nanorobotics: in vivo Applications and Commercialization Perspectives Toward Clinical Uses

Soto, Fernando; Chrostowski, Robert

doi:10.3389/fbioe.2018.00170

Cited by 99 publications

(78 citation statements)

References 93 publications

(108 reference statements)

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“…One plausible solution is to develop biohybrid microrobots that integrate self‐propelling microorganisms with functionalized synthetic nanostructures. The current generation of biohybrid platforms is based primarily on flagellated microorganisms which survive only in delicate living conditions and may not provide sufficient fluid mixing for enhancing decontamination processes. Moreover, while enzymatically powered micropumps have been utilized to generate fluid mixing, they are tailored to operate under specific environmental conditions and with their respective substrates.…”

Section: Introductionmentioning

confidence: 99%

Rotibot: Use of Rotifers as Self‐Propelling Biohybrid Microcleaners

Soto

Lopez‐Ramirez

Jeerapan

et al. 2019

Adv Funct Materials

Self Cite

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Self-propelled biohybrid microrobots, employing marine rotifers as their engine, named "rotibot," are presented and their practical utility and advantages for environmental remediation are demonstrated. Functionalized microbeads are attached electrostatically within the rotifer mouth and aggregated inside their inner lip. The high fluid flow toward the mouth, generated by the strokes of rotifer cilia bands, forces an extremely efficient transport of the contaminated sample over the active surfaces of the functionalized microbeads. The reactive particles confined around the rotifer's lip are thus exposed to a high flow rate of the pollutant solution, resulting in dramatically accelerated decontamination processes, without external mixing or harmful fuels. Theoretical simulations, modeling the greatly enhanced fluid dynamic associated with such built-in mixing effect, correlate well with the experimental observations. The rotibot thus proves to be an effective, versatile, and robust dynamic microcleaning platform for removing diverse environmental pollutants. Microbeads functionalized with lysozyme and organophosphorus hydrolase enzymes are shown to be extremely useful for enzymatic biodegradation of Escherichia coli and the nerve agent methyl paraoxon, respectively, while ligand (meso-2,3-dimercaptosuccinic acid) modified beads are used for removing heavy metal contaminants. Rotifer-based biohybrid microrobots hold considerable promise as self-propelling dynamic pumps for diverse large-scale environmental remediation applications.

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Section: Introductionmentioning

confidence: 99%

Rotibot: Use of Rotifers as Self‐Propelling Biohybrid Microcleaners

Soto

Lopez‐Ramirez

Jeerapan

et al. 2019

Adv Funct Materials

Self Cite

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“…An interesting alternative regarding the elimination of toxic fuels is the use of systems having the propulsion powered by external field that are fuel-free and allow the remote control of the movement. The MNRs with a real potential to operate in vivo are rare now and constitute an important area for future investigations that requires multi-and interdisciplinary studies [102].…”

Section: Discussionmentioning

confidence: 99%

Technological Applications of Porphyrins and Related Compounds: Spintronics and Micro-/Nanomotors

Lopes¹,

Araújo-Chaves²,

Menezes³

et al. 2019

Solid State Physics [Working Title]

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The vital role played by porphyrins in cells and their use in therapeutic processes are well known. More recently, the technological applications of porphyrins have attracted the attention of researchers. Porphyrins have the property of half-metallic material, i.e., molecules that can host transition metals making feasible the production of spin-polarized electronic states at different channels. Therefore, porphyrins and hemeproteins are among the materials that have spin-filtering property to be applied in spintronics. Molecular spintronics is an emerging and highly relevant field due to their applications to the development of high-capacity informationstorage devices and quantum computers. The catalytic properties of porphyrins and related compounds such as the hemeproteins are also applicable in the fabrication of micro-/nanomotors (MNMs). In this chapter, we describe the advances and future perspectives in the technological applications of porphyrins and related compounds in spintronic devices and micro-/nanomotors.

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“…Apart from inducing cancer, these routes are also used for the administration of therapeutic compounds. Novel protocols are proposing the use of implantable devices for programmed therapy in preclinical studies [171]. In this regard, intelligent nanoscale constructs, such as nanorobots, have been developed that are used for drug delivery to specific target sites in tumors based on specific molecules and their interactions with receptors [172].…”

Section: Retro-orbital Inoculationmentioning

confidence: 99%

Spontaneous and Induced Animal Models for Cancer Research

Onaciu

Munteanu

et al. 2020

Diagnostics

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Considering the complexity of the current framework in oncology, the relevance of animal models in biomedical research is critical in light of the capacity to produce valuable data with clinical translation. The laboratory mouse is the most common animal model used in cancer research due to its high adaptation to different environments, genetic variability, and physiological similarities with humans. Beginning with spontaneous mutations arising in mice colonies that allow for pursuing studies of specific pathological conditions, this area of in vivo research has significantly evolved, now capable of generating humanized mice models encompassing the human immune system in biological correlation with human tumor xenografts. Moreover, the era of genetic engineering, especially of the hijacking CRISPR/Cas9 technique, offers powerful tools in designing and developing various mouse strains. Within this article, we will cover the principal mouse models used in oncology research, beginning with behavioral science of animals vs. humans, and continuing on with genetically engineered mice, microsurgical-induced cancer models, and avatar mouse models for personalized cancer therapy. Moreover, the area of spontaneous large animal models for cancer research will be briefly presented.

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Frontiers of Medical Micro/Nanorobotics: in vivo Applications and Commercialization Perspectives Toward Clinical Uses

Cited by 99 publications

References 93 publications

Rotibot: Use of Rotifers as Self‐Propelling Biohybrid Microcleaners

Rotibot: Use of Rotifers as Self‐Propelling Biohybrid Microcleaners

Technological Applications of Porphyrins and Related Compounds: Spintronics and Micro-/Nanomotors

Spontaneous and Induced Animal Models for Cancer Research

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