Frontiers in research on the Maillard reaction in aging and chronic disease

Baynes, John W.; Gillery, Philippe

doi:10.1515/cclm-2013-0551

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…The flowchart for the inclusion and exclusion of these studies is presented in Figure 1 . Most of the subjects were from Asia, with the remaining patients from Italy, 21 the United States, 33 and Egypt. 36 All the trials were prospective studies.…”

Section: Resultsmentioning

confidence: 99%

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Value of Quantitative and Qualitative Analyses of Circulating Cell-Free DNA as Diagnostic Tools for Hepatocellular Carcinoma

Liao

Mao

et al. 2015

Medicine

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Section: Resultsmentioning

confidence: 99%

“…Six articles indicated that sensitivity and specificity tended to increase after AFP was included as a diagnostic indicator. 25 , 27 , 28 , 33 , 34 , 40 The detailed results are presented in Table 1 . In addition, the use of AFP assay as a control subgroup for HCC diagnoses only was assessed in 8 of these studies.…”

Section: Resultsmentioning

confidence: 99%

Value of Quantitative and Qualitative Analyses of Circulating Cell-Free DNA as Diagnostic Tools for Hepatocellular Carcinoma

Liao

Mao

et al. 2015

Medicine

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“…In addition, this analysis allows to process a considerable number of samples in a short time with low costs, providing simple spectra, thus reducing the burden of MS data generated by bottom-up approaches, making clinical studies affordable. The drawback of this approach is that it requires two steps: the first implies the presence of best separating peaks, and the second requires peak isolation by chromatography or gel-based fractionation and identification as described by our and other studies [23, 31, 32]. However, this approach enables a protein fingerprint of intact proteins of minute quantities of CSF.…”

Section: Discussionmentioning

confidence: 99%

Protein signature in cerebrospinal fluid and serum of Alzheimer’s disease patients: The case of apolipoprotein A-1 proteoforms

et al. 2017

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In the diagnosis of Alzheimer’s disease (AD) total tau (T-tau), tau phosphorylated at threonine 181 (P-tau181), and the 42 amino acid isoform of alpha β-amyloid (Aβ) are well established surrogate CSF markers. However, there is a constant need for new diagnostic markers to identify the disease at a very early stage. The identification of new molecules for AD diagnosis and monitoring in CSF is hampered by several “confounding” factors including intra- and inter-individual, pre-analytical and analytical variabilities. In an attempt to partially overcome patient’s variability and to determine new molecules significantly dysregulated in CSF, we assessed the proteome profile of low molecular weight protein species in CSF and serum of the same patients. CSFs and sera from 36 ADs, 32 iNPHs (idiopathic normal pressure hydrocephalus) and 12 controls were compared by MALDI profiling (non-parametric statistics, CV<20%, AUC>0.750). After protein identification by mass spectrometry, the proteoform composition was assessed by 2-D DIGE/MS. Results indicated that CSF of iNPH can be used as control. Serum and CSF of AD patients shows a specific protein profile compared to iNPH samples. A variation (p<0.01) of Apo A-1 levels in AD, together with a specific dysregulation of Apo A-1 proteoforms was observed. The profiling of CSF and serum of the same patients, suggests that the decrement of total Apo A-1 occurs specifically in CSF. Serum and CSF of AD shows a characteristic Apo A-1 proteoform pattern suggesting it as potential marker which can support the clinical workflow adopted for AD diagnosis and progression.

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“…Formation of AGEs on proteins is found in many tissues and is thought to contribute to a variety of age-associated diseases, such as AD and PD [ 170 ]. Although glycation is not an oxidative phenomenon, it can be amplified by oxidative stress and hence referred as to glycoxidation [ 171 ]. Thus, under conditions of oxidative stress, reducing sugars (glucose, fructose) and ascorbic acid can be self-oxidizing generating highly reactive dicarbonyl compounds, which can in turn react with proteins to form AGEs.…”

Section: Theoretical Bases and Technical Approachesmentioning

confidence: 99%

Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases

et al. 2015

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Modulation of endogenous cellular defense mechanisms via the vitagene system represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. The possibility of high-throughoutput screening using proteomic techniques, particularly redox proteomics, provide more comprehensive overview of the interaction of proteins, as well as the interplay among processes involved in neuroprotection. Here by introducing the hormetic dose response concept, the mechanistic foundations and applications to the field of neuroprotection, we discuss the emerging role of heat shock protein as prominent member of vitagene network in neuroprotection and redox proteomics as a tool for investigating redox modulation of stress responsive vitagenes. Hormetic mechanisms are reviewed as possibility of targeted therapeutic manipulation in a cell-, tissue- and/or pathway-specific manner at appropriate points in the neurodegenerative disease process.

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Frontiers in research on the Maillard reaction in aging and chronic disease

Cited by 9 publications

References 22 publications

Value of Quantitative and Qualitative Analyses of Circulating Cell-Free DNA as Diagnostic Tools for Hepatocellular Carcinoma

Value of Quantitative and Qualitative Analyses of Circulating Cell-Free DNA as Diagnostic Tools for Hepatocellular Carcinoma

Protein signature in cerebrospinal fluid and serum of Alzheimer’s disease patients: The case of apolipoprotein A-1 proteoforms

Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases

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