Frontiers in Molecular Evolutionary Medicine

Stearns, Stephen C.

doi:10.1007/s00239-019-09893-5

Cited by 18 publications

(11 citation statements)

References 48 publications

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“…These future integrative pipelines will provide novel insights into functional salivary biology. Another possibility is to add salivary proteome information from other organisms (e.g., primates [Thamadilok et al 2020] and rodents [Stopka et al 2016]) for interspecies comparisons to gain novel insights into the functions of saliva (Stearns 2020).…”

Section: Future Development Of the Hsp Wikimentioning

confidence: 99%

The Human Salivary Proteome Wiki: A Community-Driven Research Platform

et al. 2021

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Saliva has become an attractive body fluid for on-site, remote, and real-time monitoring of oral and systemic health. At the same time, the scientific community needs a saliva-centered information platform that keeps pace with the rapid accumulation of new data and knowledge by annotating, refining, and updating the salivary proteome catalog. We developed the Human Salivary Proteome (HSP) Wiki as a public data platform for researching and retrieving custom-curated data and knowledge on the saliva proteome. The HSP Wiki is dynamically compiled and updated based on published saliva proteome studies and up-to-date protein reference records. It integrates a wide range of available information by funneling in data from established external protein, genome, transcriptome, and glycome databases. In addition, the HSP Wiki incorporates data from human disease–related studies. Users can explore the proteome of saliva simply by browsing the database, querying the available data, performing comparisons of data sets, and annotating existing protein entries using a simple, intuitive interface. The annotation process includes both user feedback and curator committee review to ensure the quality and validity of each entry. Here, we present the first overview of features and functions the HSP Wiki offers. As a saliva proteome–centric, publicly accessible database, the HSP Wiki will advance the knowledge of saliva composition and function in health and disease for users across a wide range of disciplines. As a community-based data- and knowledgebase, the HSP Wiki will serve as a worldwide platform to exchange salivary proteome information, inspire novel research ideas, and foster cross-discipline collaborations. The HSP Wiki will pave the way for harnessing the full potential of the salivary proteome for diagnosis, risk prediction, therapy of oral and systemic diseases, and preparedness for emerging infectious diseases. Database URL: https://salivaryproteome.nidcr.nih.gov/

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Section: Future Development Of the Hsp Wikimentioning

confidence: 99%

The Human Salivary Proteome Wiki: A Community-Driven Research Platform

et al. 2021

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“…The bacterial “mutagenic tetrasect” (mutation, transformation, transduction, and conjugation) is responsible for the rapid evolution of bacteria and suggests that bacteria are so flexible in their ability to adapt that production of antibiotics by pharmaceutical companies, will never be able to keep up with the evolution of resistance against that drug. Fortunately, a natural alternative to conventional chemical antibiotics (Ghosh et al, 2018; Stearns, 2019) exists in the form of bacteriophages (phages). Thus, phages can evolve to efficiently target specific bacteria and have been used to treat complex drug-resistant bacterial infections in a procedure termed phage therapy (Ghosh et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Constructing and Characterizing Bacteriophage Libraries for Phage Therapy of Human Infections

et al. 2019

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Phage therapy requires libraries of well-characterized phages. Here we describe the generation of phage libraries for three target species: Escherichia coli, Pseudomonas aeruginosa, and Enterobacter cloacae. The basic phage characteristics on the isolation host, sequence analysis, growth properties, and host range and virulence on a number of contemporary clinical isolates are presented. This information is required before phages can be added to a phage library for potential human use or sharing between laboratories for use in compassionate use protocols in humans under eIND (emergency investigational new drug). Clinical scenarios in which these phages can potentially be used are discussed. The phages presented here are currently being characterized in animal models and are available for eINDs.

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“…31 Since then, evolutionary medicine has developed into a discipline that has led to major advancements in cancer, autoimmune disease, and pathogenesis of emerging diseases. 32 However, few reports have addressed evolution and kidney disease. [33][34][35] The present review is an attempt to draw on available evidence for the evolution of bioenergetic mechanisms as a determinant of nephron number in fetal life.…”

Section: (Figs 2c and D)mentioning

confidence: 99%

Bioenergetic Evolution Explains Prevalence of Low Nephron Number at Birth: Risk Factor for CKD

Chevalier

2020

Kidney360

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There is greater than tenfold variation in nephron number of the human kidney at birth. Although low nephron number is a recognized risk factor for CKD, its determinants are poorly understood. Evolutionary medicine represents a new discipline that seeks evolutionary explanations for disease, broadening perspectives on research and public health initiatives. Evolution of the kidney, an organ rich in mitochondria, has been driven by natural selection for reproductive fitness constrained by energy availability. Over the past 2 million years, rapid growth of an energy-demanding brain in Homo sapiens enabled hominid adaptation to environmental extremes through selection for mutations in mitochondrial and nuclear DNA epigenetically regulated by allocation of energy to developing organs. Maternal undernutrition or hypoxia results in intrauterine growth restriction or preterm birth, resulting in low birth weight and low nephron number. Regulated through placental transfer, environmental oxygen and nutrients signal nephron progenitor cells to reprogram metabolism from glycolysis to oxidative phosphorylation. These processes are modulated by counterbalancing anabolic and catabolic metabolic pathways that evolved from prokaryote homologs and by hypoxia-driven and autophagy pathways that evolved in eukaryotes. Regulation of nephron differentiation by histone modifications and DNA methyltransferases provide epigenetic control of nephron number in response to energy available to the fetus. Developmental plasticity of nephrogenesis represents an evolved life history strategy that prioritizes energy to early brain growth with adequate kidney function through reproductive years, the trade-off being increasing prevalence of CKD delayed until later adulthood. The research implications of this evolutionary analysis are to identify regulatory pathways of energy allocation directing nephrogenesis while accounting for the different life history strategies of animal models such as the mouse. The clinical implications are to optimize nutrition and minimize hypoxic/toxic stressors in childbearing women and children in early postnatal development.

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Frontiers in Molecular Evolutionary Medicine

Cited by 18 publications

References 48 publications

The Human Salivary Proteome Wiki: A Community-Driven Research Platform

The Human Salivary Proteome Wiki: A Community-Driven Research Platform

Constructing and Characterizing Bacteriophage Libraries for Phage Therapy of Human Infections

Bioenergetic Evolution Explains Prevalence of Low Nephron Number at Birth: Risk Factor for CKD

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