Frontiers in Gold Chemistry

Mohamed, Ahmed A.

doi:10.3390/inorganics3030370

Search citation statements

Order By: Relevance

Paper Sections

Select...

General Perspectives1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2018

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 19 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to the significant biological activities of gold compounds, the chemistry of gold has also been extensively studied owing to its distinctive chemistry [ 30 , 31 , 32 ]. In its elemental form, gold(0) appears as a bright-yellow metal with high resistance to harsh conditions, but is susceptible to reactions with aqua regia, during which oxidation to gold(III) occurs.…”

Section: General Perspectivesmentioning

confidence: 99%

Gold-Based Medicine: A Paradigm Shift in Anti-Cancer Therapy?

2018

View full text Add to dashboard Cite

A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent platinum-based complexes, commencing with cisplatin [(H3N)2PtCl2], which are effective anti-cancer chemotherapeutic drugs. While clinical applications of gold-based drugs largely relate to the treatment of rheumatoid arthritis, attention has turned to the investigation of the efficacy of gold(I) and gold(III) compounds for anti-cancer applications. This review article provides an account of the latest research conducted during the last decade or so on the development of gold compounds and their potential activities against several cancers as well as a summary of possible mechanisms of action/biological targets. The promising activities and increasing knowledge of gold-based drug metabolism ensures that continued efforts will be made to develop gold-based anti-cancer agents.

show abstract

Section: General Perspectivesmentioning

confidence: 99%