Frontiers in Cancer Epidemiology: A Challenge to the Research Community from the Epidemiology and Genomics Research Program at the National Cancer Institute

Khoury, Muin J.; Freedman, Andrew; Gillanders, Elizabeth M.; Harvey, Carol J.; Kaefer, Christie; Reid, Britt C.; Rogers, Scott D.; Schully, Sheri D.; Seminara, Daniela; Verma, Mukesh

doi:10.1158/1055-9965.epi-12-0525

Cited by 10 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Khoury et al (20) recently challenged the cancer epidemiology community to reflect on the critical scientific priorities they will be confronting in the near future. We cite a few opportunities below.…”

Section: The Futurementioning

confidence: 99%

Integrative Cancer Epidemiology—The Next Generation

2012

View full text Add to dashboard Cite

Summary We outline an integrative approach to extend the boundaries of molecular cancer epidemiology by integrating modern and rapidly evolving “omics” technologies into state-of-the-art molecular epidemiology. In this way, one can comprehensively explore the mechanistic underpinnings of epidemiologic observations into cancer risk and outcome. We highlight the exciting opportunities to collaborate across large observational studies and to forge new interdisciplinary collaborative ventures.

show abstract

Section: The Futurementioning

confidence: 99%

Integrative Cancer Epidemiology—The Next Generation

2012

View full text Add to dashboard Cite

show abstract

“…In 2012, the NCI initiated a conversation aiming to shape the future of cancer epidemiology and to establish priorities for action (6). Web-based blog posts, several commentaries (5, 6, 7, 8–11), online dialogue using social media (@NCIEpi #trendsinepi on Twitter), and an interdisciplinary workshop (12) informed the proposals presented herein.…”

mentioning

confidence: 99%

“…Web-based blog posts, several commentaries (5, 6, 7, 8–11), online dialogue using social media (@NCIEpi #trendsinepi on Twitter), and an interdisciplinary workshop (12) informed the proposals presented herein. Table 1 outlines eight broad recommendations with proposed actions targeted to funding agencies, professional societies, and the research community.…”

mentioning

confidence: 99%

Transforming Epidemiology for 21st Century Medicine and Public Health

Khoury

Lam

Ioannidis

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

Self Cite

110

View full text Add to dashboard Cite

In 2012, the National Cancer Institute (NCI) engaged the scientific community to provide a vision for cancer epidemiology in the 21st century. Eight overarching thematic recommendations, with proposed corresponding actions for consideration by funding agencies, professional societies, and the research community emerged from the collective intellectual discourse. The themes are (i) extending the reach of epidemiology beyond discovery and etiologic research to include multilevel analysis, intervention evaluation, implementation, and outcomes research; (ii) transforming the practice of epidemiology by moving towards more access and sharing of protocols, data, metadata, and specimens to foster collaboration, to ensure reproducibility and replication, and accelerate translation; (iii) expanding cohort studies to collect exposure, clinical and other information across the life course and examining multiple health-related endpoints; (iv) developing and validating reliable methods and technologies to quantify exposures and outcomes on a massive scale, and to assess concomitantly the role of multiple factors in complex diseases; (v) integrating “big data” science into the practice of epidemiology; (vi) expanding knowledge integration to drive research, policy and practice; (vii) transforming training of 21st century epidemiologists to address interdisciplinary and translational research; and (viii) optimizing the use of resources and infrastructure for epidemiologic studies. These recommendations can transform cancer epidemiology and the field of epidemiology in general, by enhancing transparency, interdisciplinary collaboration, and strategic applications of new technologies. They should lay a strong scientific foundation for accelerated translation of scientific discoveries into individual and population health benefits.

show abstract

“…As an initial step, EGRP is hosting a “longitudinal” meeting, “ Trends in 21 st Century Epidemiology: From Scientific Discoveries to Population Health Impact” in December 2012 and calling for an active on-going engagement, both online and at a workshop, from both epidemiologists and related disciplines to help reshape the field of cancer epidemiology (6). To facilitate the ongoing dialogue we have created an online forum blog-epi.grants.cancer.gov/2012.…”

mentioning

confidence: 99%

“Drivers” of Translational Cancer Epidemiology in the 21st Century: Needs and Opportunities

Lam

Spitz

Schully

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

Self Cite

View full text Add to dashboard Cite

Cancer epidemiology is at the cusp of a paradigm shift--propelled by an urgent need to accelerate the pace of translating scientific discoveries into healthcare and population health benefits. As part of a strategic planning process for cancer epidemiologic research, the Epidemiology and Genomics Research Program (EGRP) at the National Cancer Institute (NCI) is leading a “longitudinal” meeting with members of the research community to engage in an on-going dialogue to help shape and invigorate the field. Here, we review a translational framework influenced by “drivers” that we believe have begun guiding cancer epidemiology towards translation in the past few years and are most likely to drive the field further in the next decade. The drivers include: (1) collaboration and team science; (2) technology; (3) multi-level analyses and interventions; and (4) knowledge integration from basic, clinical and population sciences. Using the global prevention of cervical cancer as an example of a public health endeavor to anchor the conversation, we discuss how these drivers can guide epidemiology from discovery to population health impact, along the translational research continuum.

show abstract

Frontiers in Cancer Epidemiology: A Challenge to the Research Community from the Epidemiology and Genomics Research Program at the National Cancer Institute

Cited by 10 publications

References 9 publications

Integrative Cancer Epidemiology—The Next Generation

Integrative Cancer Epidemiology—The Next Generation

Transforming Epidemiology for 21st Century Medicine and Public Health

“Drivers” of Translational Cancer Epidemiology in the 21st Century: Needs and Opportunities

Contact Info

Product

Resources

About